Detail: | |
ncRNA Symmbol: | miR-146a |
---|---|
ncRNA Category: | miRNA |
Interaction Gene Symbol: | SMAD4 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | osteoarthritis |
PMID: | 22507670 |
Detail Description: | Smad4, a common mediator of the TGF-¦Â pathway, is identified as a direct target of miR-146a by harboring a miR-146a binding sequence in the 3'-UTR region of its mRNA.Expression of miR-146a led to a reduction of cellular responsiveness to TGF-¦Â and an increase of apoptosis rate in chondrocytes. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.