Gene ontology terms enriched for interacted genes
GO terms GO terms description target genes enrich in GO term p-value
GO:0042981
regulation of apoptosis
ROCK1,JUN,CD40LG,BCL2A1,BRCA2,EGFR,BRCA1,HSPA1A,STAT1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,NFKB1,FAF1,IRAK1,HTT,PRKCE,
3.55E-11
GO:0043067
regulation of programmed cell death
ROCK1,JUN,CD40LG,BCL2A1,BRCA2,EGFR,BRCA1,HSPA1A,STAT1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,NFKB1,FAF1,IRAK1,HTT,PRKCE,
4.28E-11
GO:0010941
regulation of cell death
ROCK1,JUN,CD40LG,BCL2A1,BRCA2,EGFR,BRCA1,HSPA1A,STAT1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,NFKB1,FAF1,IRAK1,HTT,PRKCE,
4.58E-11
GO:0007249
I-kappaB kinase/NF-kappaB cascade
TRAF6,TRAF2,TLR4,STAT1,IRAK2,TLR2,FAF1,IRAK4,IRAK1,
4.42E-10
GO:0043065
positive regulation of apoptosis
JUN,BRCA2,STAT1,BRCA1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,FAF1,PRKCE,HTT,
7.84E-9
GO:0043068
positive regulation of programmed cell death
JUN,BRCA2,STAT1,BRCA1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,FAF1,PRKCE,HTT,
8.57E-9
GO:0010942
positive regulation of cell death
JUN,BRCA2,STAT1,BRCA1,NOTCH1,CDKN1A,TRAF6,FAS,FADD,TRAF2,TLR4,TLR2,FAF1,PRKCE,HTT,
9.09E-9
GO:0009615
response to virus
TRIM22,ISG15,IFI44,IFNA1,STAT1,MX2,CXCR4,RSAD2,IRF7,
3.67E-8
GO:0006952
defense response
CD40LG,SPP1,TLR4,ITGB2,IFNA1,MX2,NMI,CCR9,CXCR4,IRAK2,TLR2,NFKB1,CFH,RSAD2,IRF7,IL8,
9.91E-8
GO:0006954
inflammatory response
CD40LG,ITGB2,SPP1,TLR4,NMI,CXCR4,IRAK2,NFKB1,TLR2,CFH,IRF7,IL8,
2.62E-7
GO:0043066
negative regulation of apoptosis
TRAF6,ROCK1,CD40LG,FAS,BCL2A1,EGFR,HSPA1A,NOTCH1,NFKB1,CDKN1A,IRAK1,HTT,
6.14E-7
GO:0043069
negative regulation of programmed cell death
TRAF6,ROCK1,CD40LG,FAS,BCL2A1,EGFR,HSPA1A,NOTCH1,NFKB1,CDKN1A,IRAK1,HTT,
7.05E-7
GO:0060548
negative regulation of cell death
TRAF6,ROCK1,CD40LG,FAS,BCL2A1,EGFR,HSPA1A,NOTCH1,NFKB1,CDKN1A,IRAK1,HTT,
7.25E-7
GO:0008219
cell death
ROCK1,JUN,BCL2A1,STAT1,BRCA1,L1CAM,TRAF6,FAS,FADD,TRAF2,ITGB2,TBP,CXCR4,NFKB1,FAF1,HTT,
7.39E-7
GO:0016265
death
ROCK1,JUN,BCL2A1,STAT1,BRCA1,L1CAM,TRAF6,FAS,FADD,TRAF2,ITGB2,TBP,CXCR4,NFKB1,FAF1,HTT,
8.06E-7
GO:0007243
protein kinase cascade
TRAF6,TRAF2,TLR4,EGFR,STAT1,NMI,CXCR4,IRAK2,TLR2,FAF1,IRAK4,IRAK1,
9.50E-7
GO:0048584
positive regulation of response to stimulus
TRAF6,TRAF2,TLR4,BRCA1,IRAK2,TLR2,IRAK1,CFH,IRF7,IL8,
1.34E-6
GO:0007242
intracellular signaling cascade
ROCK1,WASF2,BRCA2,CCNA2,EGFR,BRCA1,STAT1,TRAF6,TRAF2,TLR4,NMI,CXCR4,IRAK2,TLR2,NFATC1,FAF1,IRAK1,IRAK4,IL8,PRKCE,
2.45E-6
GO:0006955
immune response
TRIM22,CD40LG,IFITM3,NOTCH1,OASL,IFI44L,TRAF6,FAS,TLR4,CCR9,CXCR4,TLR2,CFH,RSAD2,IL8,
2.57E-6
GO:0006915
apoptosis
JUN,ROCK1,BCL2A1,STAT1,BRCA1,TRAF6,FAS,FADD,TRAF2,ITGB2,CXCR4,NFKB1,FAF1,HTT,
3.17E-6
GO:0012501
programmed cell death
JUN,ROCK1,BCL2A1,STAT1,BRCA1,TRAF6,FAS,FADD,TRAF2,ITGB2,CXCR4,NFKB1,FAF1,HTT,
3.73E-6
GO:0010033
response to organic substance
ERBB4,JUN,BRCA2,CCNA2,EGFR,HSPA1A,STAT1,BRCA1,CDKN1A,FAS,SPP1,TLR4,IRAK2,TLR2,IRAK1,
4.30E-6
GO:0009611
response to wounding
CD40LG,NOTCH1,SPP1,TLR4,ITGB2,NMI,CXCR4,IRAK2,TLR2,NFKB1,CFH,IRF7,IL8,
4.96E-6
GO:0042325
regulation of phosphorylation
TRAF6,JUN,CDKN3,TRAF2,ITGB2,TLR4,EGFR,CXCR4,SMAD4,CDKN1A,IRAK1,PRKCE,
8.78E-6
GO:0051174
regulation of phosphorus metabolic process
TRAF6,JUN,CDKN3,TRAF2,ITGB2,TLR4,EGFR,CXCR4,SMAD4,CDKN1A,IRAK1,PRKCE,
1.27E-5
GO:0019220
regulation of phosphate metabolic process
TRAF6,JUN,CDKN3,TRAF2,ITGB2,TLR4,EGFR,CXCR4,SMAD4,CDKN1A,IRAK1,PRKCE,
1.27E-5
GO:0031328
positive regulation of cellular biosynthetic process
JUN,CCNA2,BRCA1,EGFR,NOTCH1,SPI1,TRAF6,MTA2,TLR4,TBP,THRB,SMAD4,NFKB1,IRAK1,
1.28E-5
GO:0009891
positive regulation of biosynthetic process
JUN,CCNA2,BRCA1,EGFR,NOTCH1,SPI1,TRAF6,MTA2,TLR4,TBP,THRB,SMAD4,NFKB1,IRAK1,
1.50E-5
GO:0006917
induction of apoptosis
TRAF6,FAS,FADD,BRCA2,BRCA1,STAT1,TLR2,CDKN1A,HTT,PRKCE,
1.59E-5
GO:0012502
induction of programmed cell death
TRAF6,FAS,FADD,BRCA2,BRCA1,STAT1,TLR2,CDKN1A,HTT,PRKCE,
1.63E-5
GO:0002224
toll-like receptor signaling pathway
TLR4,IRAK2,TLR2,IRAK1,
3.37E-5
GO:0010557
positive regulation of macromolecule biosynthetic process
JUN,CCNA2,BRCA1,NOTCH1,SPI1,TRAF6,MTA2,TLR4,TBP,THRB,SMAD4,NFKB1,IRAK1,
4.06E-5
GO:0006916
anti-apoptosis
TRAF6,CD40LG,FAS,BCL2A1,HSPA1A,NFKB1,IRAK1,HTT,
4.60E-5
GO:0050778
positive regulation of immune response
TRAF6,TRAF2,TLR4,IRAK2,TLR2,IRAK1,CFH,
5.61E-5
GO:0006351
transcription, DNA-dependent
MSC,TBP,STAT1,NMI,THRB,NFKB1,BGLAP,NFATC1,IRF7,
5.91E-5
GO:0002221
pattern recognition receptor signaling pathway
TLR4,IRAK2,TLR2,IRAK1,
6.24E-5
GO:0032774
RNA biosynthetic process
MSC,TBP,STAT1,NMI,THRB,NFKB1,BGLAP,NFATC1,IRF7,
6.51E-5
GO:0002253
activation of immune response
TRAF6,TLR4,IRAK2,TLR2,IRAK1,CFH,
7.44E-5
GO:0002218
activation of innate immune response
TLR4,IRAK2,TLR2,IRAK1,
8.84E-5
GO:0002758
innate immune response-activating signal transduction
TLR4,IRAK2,TLR2,IRAK1,
8.84E-5
GO:0002757
immune response-activating signal transduction
TRAF6,TLR4,IRAK2,TLR2,IRAK1,
9.77E-5
GO:0006366
transcription from RNA polymerase II promoter
MSC,TBP,STAT1,NMI,NFKB1,BGLAP,NFATC1,IRF7,
1.02E-4
GO:0002684
positive regulation of immune system process
TRAF6,TRAF2,TLR4,IRAK2,TLR2,CDKN1A,IRAK1,CFH,
1.14E-4
GO:0002764
immune response-regulating signal transduction
TRAF6,TLR4,IRAK2,TLR2,IRAK1,
1.30E-4
GO:0051240
positive regulation of multicellular organismal process
TRAF6,ERBB4,CD40LG,TRAF2,SPP1,TLR4,EGFR,TLR2,
1.33E-4
GO:0051173
positive regulation of nitrogen compound metabolic process
JUN,CCNA2,MTA2,EGFR,BRCA1,TBP,NOTCH1,THRB,SMAD4,SPI1,NFKB1,IRAK1,
1.67E-4
GO:0001817
regulation of cytokine production
TRAF6,CD40LG,TRAF2,TLR4,SMAD4,NFKB1,TLR2,
1.90E-4
GO:0042127
regulation of cell proliferation
JUN,ERBB4,BRCA2,IFITM1,CCNA2,STAT1,BRCA1,EGFR,NOTCH1,CDKN1A,CDKN3,SMAD4,IL8,
2.36E-4
GO:0045941
positive regulation of transcription
JUN,CCNA2,MTA2,BRCA1,TBP,NOTCH1,THRB,SMAD4,SPI1,NFKB1,IRAK1,
2.54E-4
GO:0022402
cell cycle process
CDKN3,BRCA2,CCNA2,EGFR,BRCA1,KIF22,BGLAP,NFATC1,CDKN1A,PA2G4,IL8,
2.58E-4
GO:0048545
response to steroid hormone stimulus
ERBB4,FAS,BRCA2,CCNA2,SPP1,BRCA1,CDKN1A,
2.62E-4
GO:0007159
leukocyte adhesion
ROCK1,CD40LG,ITGB2,L1CAM,
2.90E-4
GO:0045637
regulation of myeloid cell differentiation
JUN,FAS,TLR4,SPI1,BGLAP,
3.11E-4
GO:0052255
modulation by organism of defense response of other organism during symbiotic interaction
TLR4,TLR2,IRF7,
3.16E-4
GO:0052509
positive regulation by symbiont of host defense response
TLR4,TLR2,IRF7,
3.16E-4
GO:0052031
modulation by symbiont of host defense response
TLR4,TLR2,IRF7,
3.16E-4
GO:0052510
positive regulation by organism of defense response of other organism during symbiotic interaction
TLR4,TLR2,IRF7,
3.16E-4
GO:0002755
MyD88-dependent toll-like receptor signaling pathway
IRAK2,TLR2,IRAK1,
3.16E-4
GO:0010628
positive regulation of gene expression
JUN,CCNA2,MTA2,BRCA1,TBP,NOTCH1,THRB,SMAD4,SPI1,NFKB1,IRAK1,
3.23E-4
GO:0001775
cell activation
TRAF6,CD40LG,FAS,TLR4,EGFR,CXCR4,TLR2,IL8,
3.60E-4
GO:0031349
positive regulation of defense response
TLR4,IRAK2,TLR2,IRAK1,IRF7,
3.65E-4
GO:0010604
positive regulation of macromolecule metabolic process
JUN,CCNA2,BRCA1,NOTCH1,SPI1,TRAF6,MTA2,TLR4,TBP,THRB,SMAD4,NFKB1,IRAK1,
5.14E-4
GO:0007166
cell surface receptor linked signal transduction
ERBB4,JUN,ITGBL1,WASF2,IFITM1,EGFR,STAT1,NOTCH1,L1CAM,TRAF6,ITGB2,CCR9,CXCR4,SMAD4,IRAK2,TLR2,IRAK1,RGS13,HTT,IL8,
5.52E-4
GO:0045935
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
JUN,CCNA2,MTA2,BRCA1,TBP,NOTCH1,THRB,SMAD4,SPI1,NFKB1,IRAK1,
5.67E-4
GO:0002237
response to molecule of bacterial origin
JUN,TLR4,STAT1,TLR2,IRAK1,
6.81E-4
GO:0052200
response to host defenses
TLR4,TLR2,IRF7,
7.52E-4
GO:0044003
modification by symbiont of host morphology or physiology
TLR4,TLR2,IRF7,
7.52E-4
GO:0052173
response to defenses of other organism during symbiotic interaction
TLR4,TLR2,IRF7,
7.52E-4
GO:0075136
response to host
TLR4,TLR2,IRF7,
7.52E-4
GO:0001819
positive regulation of cytokine production
TRAF6,CD40LG,TRAF2,TLR4,TLR2,
8.08E-4
GO:0045321
leukocyte activation
TRAF6,CD40LG,FAS,TLR4,CXCR4,TLR2,IL8,
8.92E-4
GO:0051092
positive regulation of NF-kappaB transcription factor activity
TLR4,IRAK2,TLR2,IRAK1,
9.04E-4
GO:0031663
lipopolysaccharide-mediated signaling pathway
STAT1,IRAK2,IRAK1,
1.14E-2
GO:0001932
regulation of protein amino acid phosphorylation
JUN,ITGB2,TLR4,EGFR,SMAD4,PRKCE,
1.24E-2
GO:0002274
myeloid leukocyte activation
TRAF6,TLR4,TLR2,IL8,
1.26E-2
GO:0045089
positive regulation of innate immune response
TLR4,IRAK2,TLR2,IRAK1,
1.26E-2
GO:0032268
regulation of cellular protein metabolic process
JUN,ITGB2,TLR4,EGFR,BRCA1,SMAD4,NFKB1,PA2G4,PRKCE,
1.52E-2
GO:0009725
response to hormone stimulus
ERBB4,FAS,BRCA2,CCNA2,SPP1,BRCA1,STAT1,CDKN1A,
1.53E-2
GO:0007250
activation of NF-kappaB-inducing kinase activity
TRAF6,TRAF2,IRAK1,
1.61E-2
GO:0045088
regulation of innate immune response
TLR4,IRAK2,TLR2,IRAK1,
2.01E-2
GO:0000082
G1/S transition of mitotic cell cycle
CDKN3,EGFR,NFATC1,CDKN1A,
2.23E-2
GO:0031399
regulation of protein modification process
JUN,ITGB2,TLR4,EGFR,BRCA1,SMAD4,PRKCE,
2.44E-2
GO:0045934
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
2.47E-2
GO:0010035
response to inorganic substance
ERBB4,JUN,EGFR,STAT1,CDKN1A,HTT,
2.62E-2
GO:0009719
response to endogenous stimulus
ERBB4,FAS,BRCA2,CCNA2,SPP1,BRCA1,STAT1,CDKN1A,
2.67E-2
GO:0051172
negative regulation of nitrogen compound metabolic process
BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
2.69E-2
GO:0051091
positive regulation of transcription factor activity
TLR4,IRAK2,TLR2,IRAK1,
2.72E-2
GO:0032655
regulation of interleukin-12 production
TRAF6,CD40LG,TLR4,
2.77E-2
GO:0007049
cell cycle
CDKN3,BRCA2,CCNA2,EGFR,BRCA1,KIF22,BGLAP,NFATC1,CDKN1A,PA2G4,IL8,
2.92E-2
GO:0022403
cell cycle phase
CDKN3,BRCA2,CCNA2,EGFR,KIF22,BGLAP,NFATC1,CDKN1A,
3.01E-2
GO:0009991
response to extracellular stimulus
JUN,BRCA2,SPP1,STAT1,BGLAP,CDKN1A,
3.55E-2
GO:0010558
negative regulation of macromolecule biosynthetic process
BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
3.71E-2
GO:0050730
regulation of peptidyl-tyrosine phosphorylation
ITGB2,TLR4,EGFR,PRKCE,
3.88E-2
GO:0010647
positive regulation of cell communication
TRAF6,ERBB4,FADD,TLR4,EGFR,SMAD4,L1CAM,
4.19E-2
GO:0043388
positive regulation of DNA binding
TLR4,IRAK2,TLR2,IRAK1,
4.22E-2
GO:0019221
cytokine-mediated signaling pathway
STAT1,IRAK2,IRAK4,IRAK1,
4.22E-2
GO:0051726
regulation of cell cycle
JUN,CDKN3,BRCA2,CCNA2,EGFR,BRCA1,CDKN1A,
4.31E-2
GO:0031327
negative regulation of cellular biosynthetic process
BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
4.32E-2
GO:0050678
regulation of epithelial cell proliferation
ERBB4,BRCA2,EGFR,NOTCH1,
4.39E-2
GO:0008633
activation of pro-apoptotic gene products
FAS,TRAF2,FADD,
4.64E-2
GO:0009890
negative regulation of biosynthetic process
BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
4.90E-2
GO:0001525
angiogenesis
JUN,WASF2,NOTCH1,CXCR4,IL8,
4.96E-2
GO:0045859
regulation of protein kinase activity
TRAF6,CDKN3,TRAF2,EGFR,CXCR4,CDKN1A,IRAK1,
5.27E-2
GO:0016481
negative regulation of transcription
MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
5.30E-2
GO:0032496
response to lipopolysaccharide
JUN,TLR4,STAT1,IRAK1,
5.51E-2
GO:0002250
adaptive immune response
TRAF6,CD40LG,FAS,TLR4,
5.51E-2
GO:0002460
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
TRAF6,CD40LG,FAS,TLR4,
5.51E-2
GO:0051098
regulation of binding
TLR4,SMAD4,IRAK2,TLR2,IRAK1,
5.58E-2
GO:0045449
regulation of transcription
JUN,TRIM22,BRCA2,CCNA2,MSC,BRCA1,STAT1,NOTCH1,SPI1,BGLAP,PA2G4,MTA2,TLR4,TBP,THRB,SMAD4,IRAK2,NFATC1,TLR2,NFKB1,IRAK1,IRF7,
5.59E-2
GO:0044093
positive regulation of molecular function
TRAF6,TRAF2,TLR4,EGFR,STAT1,CXCR4,IRAK2,TLR2,IRAK1,
5.60E-2
GO:0051099
positive regulation of binding
TLR4,IRAK2,TLR2,IRAK1,
5.71E-2
GO:0034097
response to cytokine stimulus
JUN,STAT1,IRAK2,IRAK1,
5.91E-2
GO:0043549
regulation of kinase activity
TRAF6,CDKN3,TRAF2,EGFR,CXCR4,CDKN1A,IRAK1,
6.20E-2
GO:0045893
positive regulation of transcription, DNA-dependent
JUN,MTA2,BRCA1,NOTCH1,THRB,SMAD4,SPI1,NFKB1,
6.52E-2
GO:0008285
negative regulation of cell proliferation
JUN,CDKN3,BRCA2,IFITM1,SMAD4,CDKN1A,IL8,
6.54E-2
GO:0010605
negative regulation of macromolecule metabolic process
JUN,BRCA2,MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
6.61E-2
GO:0051254
positive regulation of RNA metabolic process
JUN,MTA2,BRCA1,NOTCH1,THRB,SMAD4,SPI1,NFKB1,
6.81E-2
GO:0006979
response to oxidative stress
ERBB4,JUN,TLR4,EGFR,STAT1,
7.11E-2
GO:0009628
response to abiotic stimulus
JUN,BRCA2,EGFR,BRCA1,STAT1,CDKN1A,HTT,
7.16E-2
GO:0000278
mitotic cell cycle
CDKN3,CCNA2,EGFR,KIF22,BGLAP,NFATC1,CDKN1A,
7.35E-2
GO:0051338
regulation of transferase activity
TRAF6,CDKN3,TRAF2,EGFR,CXCR4,CDKN1A,IRAK1,
7.54E-2
GO:0010629
negative regulation of gene expression
MTA2,BRCA1,THRB,SMAD4,SPI1,NFKB1,IRF7,PA2G4,
8.71E-2
GO:0070271
protein complex biogenesis
TRIM22,FAS,TRAF2,FADD,TBP,SMAD4,IRAK1,IRF7,
8.80E-2
GO:0006461
protein complex assembly
TRIM22,FAS,TRAF2,FADD,TBP,SMAD4,IRAK1,IRF7,
8.80E-2
GO:0050865
regulation of cell activation
TRAF6,FAS,TRAF2,TLR4,CDKN1A,
8.90E-2
GO:0048661
positive regulation of smooth muscle cell proliferation
JUN,EGFR,STAT1,
9.09E-2