The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RRI00003050
RNA/Protein Symbol 1:MIR222(miR-222)
RNA/Protein Category 1: miRNA
RNA/Protein Symbol 2: SNTB1 mRNA
RNA/Protein Category 2: mRNA
Validated Method:
Tissue:  
PMID: 20856896 
Detail description:

Among the possible microRNAs (miRs) found to be upregulated in the skeletal muscle tissue of mdx compared to wt mice, we demonstrated that miR-222 specifically binds to the 3'-UTR of ¦Â1-syntrophin and participates in the downregulation of ¦Â1-syntrophin. 

The Predicated Binding Sites between MIR222 and SNTB1
By miRanda Structure Match Score Energy Score MIR222 Location SNTB1 Location 
   Query:    3' ucCUAGAUGUGACC----GAUGACUc 5'
                  |:|:| || |||    :|||||| 
   Ref:      5' auGGUUUUCAGUGGCAACUUACUGAc 3'
139.00 -17.55 2-21 907-932 
   Query:    3' uccUAGAU-GUGACCGAUGACUc 5'
                   || || |||   :|||||| 
   Ref:      5' auuAUAUAGCAC--AUUACUGAu 3'
131.00 -10.07 2-20 1130-1150 
   Query:    3' uccuagaUGUGACCGAUGACUc 5'
                       ||||   |||:||| 
   Ref:      5' aaaaauaACAC---CUAUUGAu 3'
127.00 -9.58 2-16 1189-1207
The Predicated Binding Sites between MIR222 and SNTB1
By RIsearch Structure MIR222 Location SNTB1 Location Score 
Query:    3' CUCAGUA---GCCAGUG-------UAGAUC 5'
          |||||     :||||:        :|||||
Target:   5' GAGUCUAAGAUGGUCGAAUGUCGAGUCUAG 3'
1-20 654-683 -18.17
The Predicated Binding Sites of SNTB1
RBPBD 

					

					

						RsiteDB
						
					

						BindN
						
							 

								
					

					

						BindN+
						
							 

								
					

					

					    RNAbindR
						
                              
	 
								
					

					

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Visualization:
	  
	  

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	  The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
	  the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes. 
	  
The 'First Neighbour' represents the sub-network of direct interacting with the center node, 
	  the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. 
	  Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
	 


	  

	   
	
	

  





	

		

           			
				
	
                   The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
 
				   The Binding page: representing the predicted binding sites and/or constants.
 
				   The Network page: representing the interaction sub-network of interacting RNA/Protein.