| Detail-Interactions: | |
| RAID ID: | RRI00000093 |
|---|---|
| RNA/Protein Symbol 1: | WRAP53 |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | TP53 mRNA |
| RNA/Protein Category 2: | mRNA |
| Validated Method: | |
| Tissue: | |
| PMID: | 12479855 |
| Detail description: | We observed, that an antisense p53 (p53as) transduced cell line showed marked reduction in p53 mRNA and protein expression and increased growth when compared to the control cell lines transduced with neomycin-resistance gene or untransduced cells. |
| The Predicated Binding Sites between WRAP53 and TP53 | |||||
| By miRanda | Structure | Match Score | Energy Score | WRAP53 Location | TP53 Location |
| The Predicated Binding Sites between WRAP53 and TP53 | ||||
| By RIsearch | Structure | WRAP53 Location | TP53 Location | Score | Query: 3' GAGGUGUG-GGUGAGCUG-----AUAUAAAAAGGUUUUUAUGAU 5'
:|:|||| ||||: ||: |:|::: ||:
Target: 5' UUUCACAGGGGCCUCGGGUCGUCGAUGG----ACGAGGGACCUG 3'
|
1925-1962 | 81-120 | -16.26 |
| The Predicated Binding Sites of TP53 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|P04637|P53_HUMAN Cellular tumor antigen p53 OS=Homo sapiens GN=TP53 PE=1 SV=4 Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP Prediction: --------------------------------+---+----------------------- Confidence: 855522332632362264647964898965774374429888989578886789567653 Sequence: DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK Prediction: ----+-----------+--++---+-+--++--+++-+++++++-++--+-----+-+-+ Confidence: 524367437755753643346243535326424567268887862875477537262828 Sequence: SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE Prediction: +-+---++----------+----------+++++++-+-----+-----+---++--+-- Confidence: 737322445732887389625373849625667679684366252224644786744424 Sequence: RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS Prediction: +--------------+-----+------+-+-+----------------++--------- Confidence: 652343545563367693337684254642546358984366337224566633426622 Sequence: SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP Prediction: ---++--++-----------+-++--+-+---+----+++++++-+++-+++-------- Confidence: 343663277373389484525475347344475964264969842687376722224652 Sequence: PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG Prediction: +++++++++++++++++++++-------+-+-+-+-+----------------+--++++ Confidence: 447799545667899998987232563646558274536883997889793555428577 Sequence: GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD Prediction: ++++++++++++++++++++++---+----++- Confidence: 699489995989999998957844553242544 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|P04637|P53_HUMAN Cellular tumor antigen p53 OS=Homo sapiens GN=TP53 PE=1 SV=4 Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP Prediction: ------------------------------------------------------------ Confidence: 558877986886483285257846899987998999988999999899988999999888 Sequence: DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK Prediction: ------------------------------------------+--+---+---------+ Confidence: 778779666766877987964655466554237332531113412324648246124353 Sequence: SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE Prediction: +-+---+--------+--++------------+--+-+-----+---------++++++- Confidence: 334314346821535466443271816433325225665243141433617674644743 Sequence: RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS Prediction: +-----------+--+-+++-+----------+--------------------------- Confidence: 555443325223435754342653184421117336383537438448741734436442 Sequence: SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP Prediction: +--++-+++-------------+---+-----+-+-+++++++----+-+++--+----+ Confidence: 322442567472689595456532356233355541754938613225565712321226 Sequence: PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG Prediction: ++++++---+--+++++++++---------+-++++++---------------------- Confidence: 768899232352566666765466875838638586732251361535594677874552 Sequence: GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD Prediction: -++-++++-+++++++++++++++++---+--+ Confidence: 338344443636647688978944553333114 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>P04637|TP53 Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000100101100000000142 Sequence: SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE Prediction: -----------+---+-++------+----+-+--+-+-----------------+---- Confidence: 203422421235112715631314152232527435460411001112121113472221 Sequence: RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS Prediction: --------------------------------+--------------------------- Confidence: 200112100213100102434301200011336110001021331101121121224234 Sequence: SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP Prediction: ++-++++++-------------+--+++--+++-++++++++---------------+++ Confidence: 763687556222000211433352456833759489989967342012013213333578 Sequence: PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG Prediction: +++++++-++---++-+++++---------+++++++++--+--+--------------- Confidence: 898788635633465457755210110244879988876237317333201001011210 Sequence: GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD Prediction: -++----------+++++++++++-++-+++++- Confidence: 4563212214433576799799653654785780 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP Prediction: ------------------------------------------------------------ Confidence: 210300000000000000000000000000000000110000000000000000000000 Sequence: DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK Prediction: -------------------------------------------+-++--+-+++++++-+ Confidence: 000000000000000000000000000000000200000100063652172555654524 Sequence: SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE Prediction: --+--------+---+-+++-+------++++++++-+-----+-----+---+++++++ Confidence: 204200100038312503653401010147865963070112242001032115869978 Sequence: RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS Prediction: +++--+++----+-------------------+---+---------------------++ Confidence: 844325430100400202002301101123224121422110000000000000100048 Sequence: SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP Prediction: ++++++-++-----------------++++--+++++++++++-++++++++++++++++ Confidence: 998688278312000100000033138877006579999979624589565743364766 Sequence: PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG Prediction: ++++++-+++++++------------------+++++++-----------------+-+- Confidence: 656555245556663313111001000000326576644112001000001001003142 Sequence: GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD Prediction: ++++++++++++++++++++++++-++-+++++ Confidence: 457698996997899877879964366256446 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.