The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RRI00000054
RNA/Protein Symbol 1:HULC
RNA/Protein Category 1: lncRNA
RNA/Protein Symbol 2: MIR372(miR-372)
RNA/Protein Category 2: miRNA
Validated Method:
Tissue:  
PMID: 21802130 
Detail description:

They also demonstrated that HULC RNA inhibits miR-372 activity through a ceRNA function. This in turn leads to derepression of one of its target genes, PRKACB, which can then induce the phosphorylation and activation of CREB. Overall, HULC lncRNA is part of a self-amplifying autoregulatory loop in which it sponges miR-372 to activate CREB, and in turn upregulates its own levels. 

The Predicated Binding Sites between MIR372 and HULC
By miRanda Structure Match Score Energy Score MIR372 Location HULC Location 
   Query:    3' ucuuaucACGAGGUGUAAACucc 5'
                       ||:  || |||||   
   Ref:      5' uucaaccUGUGGCAAAUUUGuac 3'
112.00 -6.05 4-17 338-360 
   Query:    3' ucUUAUCACGAGGUGUAAACUCc 5'
                  | |  || |  | ||| ||| 
   Ref:      5' gaACUCAUGAUGGA-AUUGGAGc 3'
111.00 -5.88 2-22 10-31 
   Query:    3' ucUUAUCACGAGGUGUAAACUcc 5'
                  :|| |||    |||||| |  
   Ref:      5' cuGAUCGUG---GACAUUUCAac 3'
101.00 -3.97 3-22 145-164
The Predicated Binding Sites between MIR372 and HULC
By RIsearch Structure MIR372 Location HULC Location Score 
Query:    3' CCUCAAAUGUGG---------AGCACUAUUCU 5'
          |||||  :||||         ||| ||  |||
Target:   5' GGAGU--GCACCGUAUUUCUCUCGAGAACAGA 3'
1-23 50-79 -11.89
The Predicated Binding Sites of HULC
RBPBD 

					

					

						RsiteDB
						
					

						BindN
						
							 

								
					

					

						BindN+
						
							 

								
					

					

					    RNAbindR
						
                              
	 
								
					

					

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Visualization:
	  
	  

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	  The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
	  the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes. 
	  
The 'First Neighbour' represents the sub-network of direct interacting with the center node, 
	  the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. 
	  Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
	 


	  

	   
	
	

  





	

		

           			
				
	
                   The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
 
				   The Binding page: representing the predicted binding sites and/or constants.
 
				   The Network page: representing the interaction sub-network of interacting RNA/Protein.