The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RRI00000012
RNA/Protein Symbol 1:HULC
RNA/Protein Category 1: lncRNA
RNA/Protein Symbol 2: MIR372(miR-372)
RNA/Protein Category 2: miRNA
Validated Method: RT-PCR, Luciferase reporter assay, Western blot
Tissue: Tumorous liver tissue 
PMID: 20423907 
Detail description:

Furthermore, we demonstrated HULC may act as an endogenous `sponge`,which down-regulates a series of microRNAs (miRNAs) activities, including miR-372. 

The Predicated Binding Sites between MIR372 and HULC
By miRanda Structure Match Score Energy Score MIR372 Location HULC Location 
   Query:    3' ucuuaucACGAGGUGUAAACucc 5'
                       ||:  || |||||   
   Ref:      5' uucaaccUGUGGCAAAUUUGuac 3'
112.00 -6.05 4-17 338-360 
   Query:    3' ucUUAUCACGAGGUGUAAACUCc 5'
                  | |  || |  | ||| ||| 
   Ref:      5' gaACUCAUGAUGGA-AUUGGAGc 3'
111.00 -5.88 2-22 10-31 
   Query:    3' ucUUAUCACGAGGUGUAAACUcc 5'
                  :|| |||    |||||| |  
   Ref:      5' cuGAUCGUG---GACAUUUCAac 3'
101.00 -3.97 3-22 145-164
The Predicated Binding Sites between MIR372 and HULC
By RIsearch Structure MIR372 Location HULC Location Score 
Query:    3' CCUCAAAUGUGG---------AGCACUAUUCU 5'
          |||||  :||||         ||| ||  |||
Target:   5' GGAGU--GCACCGUAUUUCUCUCGAGAACAGA 3'
1-23 50-79 -11.89
The Predicated Binding Sites of HULC
RBPBD 

					

					

						RsiteDB
						
					

						BindN
						
							 

								
					

					

						BindN+
						
							 

								
					

					

					    RNAbindR
						
                              
	 
								
					

					

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Visualization:
	  
	  

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	  The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
	  the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes. 
	  
The 'First Neighbour' represents the sub-network of direct interacting with the center node, 
	  the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. 
	  Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
	 


	  

	   
	
	

  





	

		

           			
				
	
                   The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
 
				   The Binding page: representing the predicted binding sites and/or constants.
 
				   The Network page: representing the interaction sub-network of interacting RNA/Protein.