Detail

Detail-Interactions:
RAID ID:	RPI00001610
RNA/Protein Symbol 1:	TERC(htr)
RNA/Protein Category 1:	snoRNA
RNA/Protein Symbol 2:	NFKB1
RNA/Protein Category 2:	Protein
Validated Method:	quantitative fluorescent reverse transcription polymerase chain reaction
Tissue:	bladder cancer cell line biu-99
PMID:	20556588
Detail description:	The effects of combined RNA interference (RNAi) of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) genes on telomerase activity in a bladder cancer cell line (BIU-87 cells) were investigated by using gene chip technology in vitro with an attempt to evaluate the role of RNAi in the gene therapy of bladder transitional cell cancer (BTCC). HTR-siRNA and hTERT-siRNA, especially their combination, siRNA hTR+hTERT, specifically and effectively suppressed the expression of both hTR and hTERT mRNA and telomerase activity. Gene chip analysis revealed that 21 genes were down-regulated (ATM, BAX, BCL2, BCL2L1, BIRC5, CD44, CTNNB1, E2F1, JUN, MCAM, MTA1, MYC, NFKB1, NFKBIA, NME4, PNN, PNN, SERPINE1, THBS1, TNFRSF1A, and UCC1).

Detail-Interactions:

RAID ID:

RPI00001610

RNA/Protein Symbol 1:

TERC(htr)

RNA/Protein Category 1:

snoRNA

RNA/Protein Symbol 2:

NFKB1

RNA/Protein Category 2:

Protein

Validated Method:

quantitative fluorescent reverse transcription polymerase chain reaction

Tissue:

bladder cancer cell line biu-99

PMID:

20556588

Detail description:

The effects of combined RNA interference (RNAi) of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) genes on telomerase activity in a bladder cancer cell line (BIU-87 cells) were investigated by using gene chip technology in vitro with an attempt to evaluate the role of RNAi in the gene therapy of bladder transitional cell cancer (BTCC). HTR-siRNA and hTERT-siRNA, especially their combination, siRNA hTR+hTERT, specifically and effectively suppressed the expression of both hTR and hTERT mRNA and telomerase activity. Gene chip analysis revealed that 21 genes were down-regulated (ATM, BAX, BCL2, BCL2L1, BIRC5, CD44, CTNNB1, E2F1, JUN, MCAM, MTA1, MYC, NFKB1, NFKBIA, NME4, PNN, PNN, SERPINE1, THBS1, TNFRSF1A, and UCC1).

>sp|P19838|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens GN=NFKB1 PE=1 SV=2 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ---------+----------------------------------------++++-+-+-- Confidence: 898985254666369796637224987879759678643343284874337586377538 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: ----++---+-++++++++++-+-+--------+---------++-+--------+---- Confidence: 435365322626899999878256487337548478859822564546485366645766 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: -----+------------------++++----------+---+-+-----------+--- Confidence: 878275344276898894887827454576438572724758765355789688875837 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----++-----+---+-------+-------+----------+-+++++--+------- Confidence: 322237622225526763855222466575896988598965262744869348826682 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: --+--+-+--+--+--++----+------------------------------------- Confidence: 637427352665567484233555667949996272263529293777747783787968 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: --+---+------++-+++----++--+-----+++++-+++--+-------------++ Confidence: 245263678878755265535265546573525475562565256358346572633247 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++++------------+++++-+-----+--+++++++++++++--------+-----+ Confidence: 858673254745234227556424223337227888979977476443355425446255 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ++++++++--+--+-++++++-++---+++-+++-------------++--------+-- Confidence: 547898942272263567776345242654274562778288422344543226254553 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ----+-+-++--+----------------++----------------------------- Confidence: 626354626632535847698984972436535268986982768289789525825645 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: -------------------+---------------------------------------- Confidence: 426637859998595248959997932488478885923452245967777326788989 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: --+-----+---+----------+-------+------+--------------------- Confidence: 996846774687476248827676343638857582425766697562555639959978 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: -----------------+-++++++++--------------------------+++++-+ Confidence: 333856999999766455455697596462889888483787799878773725767626 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: +-------+++++-----+---------------------------------++------ Confidence: 436244328687863579566575589999989799785564577967664555342352 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: ----------+-+---------------+------+-------------+---------- Confidence: 467999983564523373476877374744885894849449978455453362583287 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: --------+-++-++++-------+----+------+--------------+++++++++ Confidence: 568833687765355744584666524286688799635423698899385788587777 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -++---++++++------+-----------++-++-------++--+-----+------- Confidence: 346635674768234549474436652452555666242236554454627244324262 Sequence: EGPLEGKI Prediction: ------+- Confidence: 45254659 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

>sp|P19838|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens GN=NFKB1 PE=1 SV=2 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------+-------------------------------------++++++-++- Confidence: 588995485487354598876856666667578999986674295696225393484776 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +++++++++++-++-++++-+-------+---------------+++-+-+----+---- Confidence: 644777773543471434743149284244126396827621523462644163645545 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: ------------------------+++-----------------++-------------- Confidence: 778794936234374652754523576579889792847649323455568777584757 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----------------------------+--+------------+--+----------- Confidence: 766452454537537513648577558663676625385978522455418567924441 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: -+++------+--+-+++--+------------+-------------------------- Confidence: 547512224656763453123413355859984453256657376889978953685777 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: ------+------+-++++--+-----+-+-+-+++++--+++-+--------------+ Confidence: 344242734345641478534473367563745474431144433333243584522125 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++-+---------------+++++++-------+------------------------- Confidence: 676244564656545344214345433364483432123264515744467565457693 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ----+------------------------------------------------------- Confidence: 764333165342348878876798998858778685999799899799996799799688 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ------------------------------------------------------------ Confidence: 689988696376676989587842753644547479666876889899798746848936 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: ------------------------------------------------------------ Confidence: 735727818687575899949995886788888775925663625728686555789959 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: ------------------------------------------------------------ Confidence: 892446241534344338939893564899959995563888996875867959959786 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: ------------------------------------------------------------ Confidence: 766999999998798572833422432874989578589996998857883315322454 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: -----------------------------------------------------+------ Confidence: 377498963623899799643463358347769699998987989887663434453745 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: ------------------------------------------------------------ Confidence: 666999995735354785687899798989999997989769989986345467796798 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: ------------------------------------------------------------ Confidence: 885857995988765436774977557372578789577879669699488733655442 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -------+-+-+------+-----------++-+--+--------------------+-+ Confidence: 847743132423454667476425652342744416464329234436727222213433 Sequence: EGPLEGKI Prediction: ------+- Confidence: 53374344 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

>P19838|NFKB1 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------------------------------------------++++++-+++-+ Confidence: 000000000000000000000000000000000000001133402412766895488745 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +++++++++++-+-+++++++++++-++++++-----++-+++++++++-+++++++-+- Confidence: 667875876564647779969867927877764234375256668686836856565153 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: --------------++++++++++++++-+---------------+-------------- Confidence: 121103023234426579788999999745413124211111223632101000000000 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----------------------------+--+++-+---------------+--++-++ Confidence: 001003100000000000000000140447248664614013224403110362058479 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: ++++++++++++++-++++++++++++------+-++-+++-+----------------- Confidence: 799868575595794886789696665242122735746663511401121002202012 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: --+--+++--+--++++++----------+-+-++++++-+++-----------+---+- Confidence: 245216653462477776732312310436262686958365512331133223623364 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++++------------------------------------------------------- Confidence: 898564312211110010011011323110232112001100000000000000000000 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ------------------------------------------------------------ Confidence: 000000000000002100200001002000120010001000000300012222031121 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: ------------------------------------------+--++------------- Confidence: 212241241322414020001000000000000000013234544562323433040032 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: ------+-----++++++++-----------------------------+-+++++++++ Confidence: 112343514214785877774313110100000002123220113024363755575656 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: +-+-+--------+------+-++++++++---------------------------+++ Confidence: 547461023314454203145488899777200000000000210010300021222756 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: ++++-+--+--------------------------------------------------- Confidence: 875606436110400212022300110100000000000000000000001121100000 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: -----------------------------------------------------+--++-- Confidence: 000000000010000000000000000000000000000010010112232445025634 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: ------------------------------------------------------------ Confidence: 132000000000231111012010001202301210210010200000010000000000 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: ---------------------------------------------------------+++ Confidence: 000000000000000000000011012201110310101010000321000221234567 Sequence: EGPLEGKI Prediction: --+---+-- Confidence: 235044610 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------------------------------------------+-+++-++++++ Confidence: 100010300000000000000000000000000000001002001100434581493977 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +-++++++++++++-++++++-------------------+++++++++++++--+--+- Confidence: 537997485647472666748333000002120312000245659697954461231143 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: ---------+-++--++++++++++++--------------+++++++------------ Confidence: 230103321434623466768733434301001002011024576434312011111121 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -------------------+--+++++-++----------+++++++++----------- Confidence: 221222221121111221232234543244002200000067755555430000000001 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: --+--++++++-+++++++++++---------------------------------+--- Confidence: 024326655561494998988651100000000100000000000000113233003000 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: ---+--+------+++++---+-----+-+-+-++++++--+------------++++++ Confidence: 100400601110064476312702012504363896767234200210000002553688 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +-+++---+--------+-+--+-+++++++++++-++-+-+--------+--+-+---+ Confidence: 635682203000000236363343657354536553552524220101233015233113 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: -++++-+--+-+---+-------------------------------------------- Confidence: 235652633436320401011000001002002102110100100010000000010003 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: --------++--+-+---+----------------+-++-+------------------- Confidence: 200000003312423220532012213200120223355230000102023310031122 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: -+-+++-+--------------------+---------------+++-----------+- Confidence: 242856391102000000020002100131011113001222306480002000121040 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: --+----+---+-----+-+-------------------------------++--+---- Confidence: 005310050103020314170002000000010000300020001010121333270000 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: ------------+---+--++++-++++++----------------++++++-------- Confidence: 000000000011513252334472568748000000001000010267766632001202 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: -+-+----------------+---+-------+---------------+-+-+++++--- Confidence: 150500000222110100015012830011334000010111311301323355446201 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: --++--------------------+---+--------------------+---+---+-- Confidence: 104421100021000000002110423142002020100000000002332018203701 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: -+---+---------+---+--+---+------------------------+++------ Confidence: 263236102003012400030340113000000000000000000000123466123100 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -------+++-----------+---------------------------------+++++ Confidence: 000003154503000000321530000112010000110133100000000032145544 Sequence: EGPLEGKI Prediction: ------+- Confidence: 31102141 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest).

The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.

The Predicated Binding Sites between TERC and NFKB1
By miRanda	Structure	Match Score	Energy Score	TERC Location	NFKB1 Location

The Predicated Binding Sites between TERC and NFKB1
By RIsearch	Structure	TERC Location	NFKB1 Location	Score

The Predicated Binding Sites of NFKB1
RBPBD
RsiteDB
BindN	>sp\|P19838\|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens GN=NFKB1 PE=1 SV=2 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ---------+----------------------------------------++++-+-+-- Confidence: 898985254666369796637224987879759678643343284874337586377538 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: ----++---+-++++++++++-+-+--------+---------++-+--------+---- Confidence: 435365322626899999878256487337548478859822564546485366645766 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: -----+------------------++++----------+---+-+-----------+--- Confidence: 878275344276898894887827454576438572724758765355789688875837 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----++-----+---+-------+-------+----------+-+++++--+------- Confidence: 322237622225526763855222466575896988598965262744869348826682 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: --+--+-+--+--+--++----+------------------------------------- Confidence: 637427352665567484233555667949996272263529293777747783787968 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: --+---+------++-+++----++--+-----+++++-+++--+-------------++ Confidence: 245263678878755265535265546573525475562565256358346572633247 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++++------------+++++-+-----+--+++++++++++++--------+-----+ Confidence: 858673254745234227556424223337227888979977476443355425446255 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ++++++++--+--+-++++++-++---+++-+++-------------++--------+-- Confidence: 547898942272263567776345242654274562778288422344543226254553 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ----+-+-++--+----------------++----------------------------- Confidence: 626354626632535847698984972436535268986982768289789525825645 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: -------------------+---------------------------------------- Confidence: 426637859998595248959997932488478885923452245967777326788989 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: --+-----+---+----------+-------+------+--------------------- Confidence: 996846774687476248827676343638857582425766697562555639959978 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: -----------------+-++++++++--------------------------+++++-+ Confidence: 333856999999766455455697596462889888483787799878773725767626 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: +-------+++++-----+---------------------------------++------ Confidence: 436244328687863579566575589999989799785564577967664555342352 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: ----------+-+---------------+------+-------------+---------- Confidence: 467999983564523373476877374744885894849449978455453362583287 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: --------+-++-++++-------+----+------+--------------+++++++++ Confidence: 568833687765355744584666524286688799635423698899385788587777 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -++---++++++------+-----------++-++-------++--+-----+------- Confidence: 346635674768234549474436652452555666242236554454627244324262 Sequence: EGPLEGKI Prediction: ------+- Confidence: 45254659 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
BindN+	>sp\|P19838\|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens GN=NFKB1 PE=1 SV=2 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------+-------------------------------------++++++-++- Confidence: 588995485487354598876856666667578999986674295696225393484776 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +++++++++++-++-++++-+-------+---------------+++-+-+----+---- Confidence: 644777773543471434743149284244126396827621523462644163645545 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: ------------------------+++-----------------++-------------- Confidence: 778794936234374652754523576579889792847649323455568777584757 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----------------------------+--+------------+--+----------- Confidence: 766452454537537513648577558663676625385978522455418567924441 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: -+++------+--+-+++--+------------+-------------------------- Confidence: 547512224656763453123413355859984453256657376889978953685777 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: ------+------+-++++--+-----+-+-+-+++++--+++-+--------------+ Confidence: 344242734345641478534473367563745474431144433333243584522125 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++-+---------------+++++++-------+------------------------- Confidence: 676244564656545344214345433364483432123264515744467565457693 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ----+------------------------------------------------------- Confidence: 764333165342348878876798998858778685999799899799996799799688 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ------------------------------------------------------------ Confidence: 689988696376676989587842753644547479666876889899798746848936 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: ------------------------------------------------------------ Confidence: 735727818687575899949995886788888775925663625728686555789959 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: ------------------------------------------------------------ Confidence: 892446241534344338939893564899959995563888996875867959959786 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: ------------------------------------------------------------ Confidence: 766999999998798572833422432874989578589996998857883315322454 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: -----------------------------------------------------+------ Confidence: 377498963623899799643463358347769699998987989887663434453745 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: ------------------------------------------------------------ Confidence: 666999995735354785687899798989999997989769989986345467796798 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: ------------------------------------------------------------ Confidence: 885857995988765436774977557372578789577879669699488733655442 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -------+-+-+------+-----------++-+--+--------------------+-+ Confidence: 847743132423454667476425652342744416464329234436727222213433 Sequence: EGPLEGKI Prediction: ------+- Confidence: 53374344 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
RNAbindR	>P19838\|NFKB1 Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------------------------------------------++++++-+++-+ Confidence: 000000000000000000000000000000000000001133402412766895488745 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +++++++++++-+-+++++++++++-++++++-----++-+++++++++-+++++++-+- Confidence: 667875876564647779969867927877764234375256668686836856565153 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: --------------++++++++++++++-+---------------+-------------- Confidence: 121103023234426579788999999745413124211111223632101000000000 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -----------------------------+--+++-+---------------+--++-++ Confidence: 001003100000000000000000140447248664614013224403110362058479 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: ++++++++++++++-++++++++++++------+-++-+++-+----------------- Confidence: 799868575595794886789696665242122735746663511401121002202012 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: --+--+++--+--++++++----------+-+-++++++-+++-----------+---+- Confidence: 245216653462477776732312310436262686958365512331133223623364 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +++++------------------------------------------------------- Confidence: 898564312211110010011011323110232112001100000000000000000000 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: ------------------------------------------------------------ Confidence: 000000000000002100200001002000120010001000000300012222031121 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: ------------------------------------------+--++------------- Confidence: 212241241322414020001000000000000000013234544562323433040032 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: ------+-----++++++++-----------------------------+-+++++++++ Confidence: 112343514214785877774313110100000002123220113024363755575656 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: +-+-+--------+------+-++++++++---------------------------+++ Confidence: 547461023314454203145488899777200000000000210010300021222756 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: ++++-+--+--------------------------------------------------- Confidence: 875606436110400212022300110100000000000000000000001121100000 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: -----------------------------------------------------+--++-- Confidence: 000000000010000000000000000000000000000010010112232445025634 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: ------------------------------------------------------------ Confidence: 132000000000231111012010001202301210210010200000010000000000 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: ---------------------------------------------------------+++ Confidence: 000000000000000000000011012201110310101010000321000221234567 Sequence: EGPLEGKI Prediction: --+---+-- Confidence: 235044610 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
Pprint	Sequence: MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV Prediction: ------------------------------------------------+-+++-++++++ Confidence: 100010300000000000000000000000000000001002001100434581493977 Sequence: CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED Prediction: +-++++++++++++-++++++-------------------+++++++++++++--+--+- Confidence: 537997485647472666748333000002120312000245659697954461231143 Sequence: GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA Prediction: ---------+-++--++++++++++++--------------+++++++------------ Confidence: 230103321434623466768733434301001002011024576434312011111121 Sequence: EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY Prediction: -------------------+--+++++-++----------+++++++++----------- Confidence: 221222221121111221232234543244002200000067755555430000000001 Sequence: DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF Prediction: --+--++++++-+++++++++++---------------------------------+--- Confidence: 024326655561494998988651100000000100000000000000113233003000 Sequence: SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ Prediction: ---+--+------+++++---+-----+-+-+-++++++--+------------++++++ Confidence: 100400601110064476312702012504363896767234200210000002553688 Sequence: RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH Prediction: +-+++---+--------+-+--+-+++++++++++-++-+-+--------+--+-+---+ Confidence: 635682203000000236363343657354536553552524220101233015233113 Sequence: PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE Prediction: -++++-+--+-+---+-------------------------------------------- Confidence: 235652633436320401011000001002002102110100100010000000010003 Sequence: VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD Prediction: --------++--+-+---+----------------+-++-+------------------- Confidence: 200000003312423220532012213200120223355230000102023310031122 Sequence: ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED Prediction: -+-+++-+--------------------+---------------+++-----------+- Confidence: 242856391102000000020002100131011113001222306480002000121040 Sequence: LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM Prediction: --+----+---+-----+-+-------------------------------++--+---- Confidence: 005310050103020314170002000000010000300020001010121333270000 Sequence: SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT Prediction: ------------+---+--++++-++++++----------------++++++-------- Confidence: 000000000011513252334472568748000000001000010267766632001202 Sequence: TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT Prediction: -+-+----------------+---+-------+---------------+-+-+++++--- Confidence: 150500000222110100015012830011334000010111311301323355446201 Sequence: SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG Prediction: --++--------------------+---+--------------------+---+---+-- Confidence: 104421100021000000002110423142002020100000000002332018203701 Sequence: LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ Prediction: -+---+---------+---+--+---+------------------------+++------ Confidence: 263236102003012400030340113000000000000000000000123466123100 Sequence: AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ Prediction: -------+++-----------+---------------------------------+++++ Confidence: 000003154503000000321530000112010000110133100000000032145544 Sequence: EGPLEGKI Prediction: ------+- Confidence: 31102141 *Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *Confidence: from level 0 (lowest) to level 9 (highest).

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The Detail Information for This Interaction