Detail

Detail-Interactions:
RAID ID:	RPI00001607
RNA/Protein Symbol 1:	TERC(htr)
RNA/Protein Category 1:	snoRNA
RNA/Protein Symbol 2:	MCAM
RNA/Protein Category 2:	Protein
Validated Method:	quantitative fluorescent reverse transcription polymerase chain reaction
Tissue:	bladder cancer cell line biu-96
PMID:	20556588
Detail description:	The effects of combined RNA interference (RNAi) of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) genes on telomerase activity in a bladder cancer cell line (BIU-87 cells) were investigated by using gene chip technology in vitro with an attempt to evaluate the role of RNAi in the gene therapy of bladder transitional cell cancer (BTCC). HTR-siRNA and hTERT-siRNA, especially their combination, siRNA hTR+hTERT, specifically and effectively suppressed the expression of both hTR and hTERT mRNA and telomerase activity. Gene chip analysis revealed that 21 genes were down-regulated (ATM, BAX, BCL2, BCL2L1, BIRC5, CD44, CTNNB1, E2F1, JUN, MCAM, MTA1, MYC, NFKB1, NFKBIA, NME4, PNN, PNN, SERPINE1, THBS1, TNFRSF1A, and UCC1).

Detail-Interactions:

RAID ID:

RPI00001607

RNA/Protein Symbol 1:

TERC(htr)

RNA/Protein Category 1:

snoRNA

RNA/Protein Symbol 2:

MCAM

RNA/Protein Category 2:

Protein

Validated Method:

quantitative fluorescent reverse transcription polymerase chain reaction

Tissue:

bladder cancer cell line biu-96

PMID:

20556588

Detail description:

The effects of combined RNA interference (RNAi) of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) genes on telomerase activity in a bladder cancer cell line (BIU-87 cells) were investigated by using gene chip technology in vitro with an attempt to evaluate the role of RNAi in the gene therapy of bladder transitional cell cancer (BTCC). HTR-siRNA and hTERT-siRNA, especially their combination, siRNA hTR+hTERT, specifically and effectively suppressed the expression of both hTR and hTERT mRNA and telomerase activity. Gene chip analysis revealed that 21 genes were down-regulated (ATM, BAX, BCL2, BCL2L1, BIRC5, CD44, CTNNB1, E2F1, JUN, MCAM, MTA1, MYC, NFKB1, NFKBIA, NME4, PNN, PNN, SERPINE1, THBS1, TNFRSF1A, and UCC1).

>sp|P43121|MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens GN=MCAM PE=1 SV=2 Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ----+--------------+---------------------++---+---++++-+---- Confidence: 778759979999998667668636232643586799795655646665246676345239 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ------+-+++---+-++++-+++++++--+-+---+--+----+------+----+-++ Confidence: 756473437745346874582867545532675522746857635723376497656399 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: +++++++-+-+-++----------------+++------+---++-+---------+-++ Confidence: 898957964567455445438283475525657352487444484463863894425385 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ++-++++-+-+++++--++--+-----------+--+----------+--++++-+--+- Confidence: 482574847365556427526628336827265567556384868635536554273254 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: -+--------------------+---+-----------------++++++++--+----- Confidence: 657687273539397997886753647626277754223325255689776822623223 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: ----------+++++++-------------------------------+-----++++++ Confidence: 527888833487698592232574963894884686788986936928523222855667 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: -+------+----------------------------++--++-++------+-----+- Confidence: 456252445227658648276462664274684934656435445845427444325262 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: -----------------++---------------++--+++-------+-+++-+---+- Confidence: 266299978785757375573838999859364375228456232723527542534257 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: -+-----------------+-++---+-------------+-+-++++++++++++++++ Confidence: 552947894879864584545452227322898999958453426757886567785866 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: +++++++++++--+--++--------------------------+-+++-++++++--+- Confidence: 896999877864273257666899999999999997899378325396829984762664 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: -++++-------+--+----------+++++++++++--+----+- Confidence: 2659622748586224547989682488779945566335275844 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

>sp|P43121|MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens GN=MCAM PE=1 SV=2 Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ------------------------------------------------------------ Confidence: 126557679899998979837868388977796877696847397938364737888549 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ----------------+-----------------------------------------+- Confidence: 656464676347574733325244543263262644159287832744544387691933 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: -+---------------------------------------------------------- Confidence: 533433294818255657437274676689584786899776514423962952325535 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ------------------------------------------------------------ Confidence: 545445465723633977668659466758486245438796949653544423433547 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: ------------------------------------------------------------ Confidence: 869586463566576876765555864969686735347527353136522234455324 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: ------------------------------------------------------------ Confidence: 649898956712432645664874854775865888986878867958668685456865 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: ------------------+----------------------------------------- Confidence: 979796775449617525435242343252386833812464677486935544547324 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: ----------------------------------------+------------------- Confidence: 779797948856976783585746476969673623222547634658555744356337 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: ------------------------------------------------------------ Confidence: 774969666537657773818126321534697969748658686454634844446446 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: --------------------------------------------+-+-+++++------- Confidence: 318364275337635452889999979998899998679767313171568731256548 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: ------------+-------------++--++-++-----+---++ Confidence: 5241157768873242688988993543114746621233444465 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

>P43121|MCAM Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: -+---------------------------------------------------------- Confidence: 453441200000000002440141220000000000010112122022200121121210 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ----------------+--------------------------------+-+---+--++ Confidence: 110000112101113251020000001020100000110321032142262714153258 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: -+-+------+--------------------------------++++++++-+++++++- Confidence: 463544213060012201110100010000000000000212055599679269686563 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ----------------------------------------+-++-+-------------- Confidence: 101100000001100100142130032210422211312464661531132242200000 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: ----------------------------------++++--+--+-+-------------- Confidence: 010202112230110001011212121110132356874362253501010000100000 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: -------------++--+++---------------------------------------- Confidence: 001001021133155445564013022301100000000010011121100000000011 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: --------+++++++++++---+------++----+----+-+++--------------- Confidence: 000110435688675576742353113345544036123154555242123011311111 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: -------+-++++++++------------------++++++------------------- Confidence: 110103153775555554214411141121131235576653143211200100012141 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: ---------------------+++------------------------------------ Confidence: 124130211200102214441575322002000000100111000000000000000000 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: -----------------+++-+++----------------++++++++++++++------ Confidence: 000000111100233136763566343311312101101475789799888965423121 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: ---------------+-----------+--++++++++-------+- Confidence: 22224210211013352243210141262488797786424141470 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest).

Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ----+---------------------------------------+-----+++------- Confidence: 302030000000000000000000000000000010001201304020303450102020 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: +------+++--+---+--+-+--------+--++-++++-+-+-----++++++++-++ Confidence: 331222135432421062143432101100332540564724040002286797939099 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: +++++-+-+--------------------------------------+--+--------- Confidence: 496761505010000000000100213110000000000000000024005000030310 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ------------------------------++++-+++++-+---+---++-+-+++++- Confidence: 001002213210132210213110121120647434433804020402356373453453 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: -+-----+-----------------------------+-++-+---+++++--------- Confidence: 040202142000000030300200000000200002333673500255544112011200 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: -----------+-------------+---+-----------+------------------ Confidence: 000202032124130020102011050214320010101024201010111100000000 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: --------+++--+-+--+---+-------+----+--++++++-+-+-++---+-+++- Confidence: 010000013452372300503040021001523024028767382505045233433353 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: --------++-------++---------+-------+++++-+----+----------++ Confidence: 110000024402100104410100000050100010443692420014211220022334 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: --+-+----+++-+-+---+-++++++++++----------------------------- Confidence: 235173230553340722240677997365400000001000000000000000000000 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: -----------------++----+---+---------------++++++++++++++++- Confidence: 000003211112132125432124320510000000000101364499999996634361 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: -++----------------------++++++++--++-+---+-+- Confidence: 2351202010000003000021003566766953235131223043 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest).

The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.

The Predicated Binding Sites between TERC and MCAM
By miRanda	Structure	Match Score	Energy Score	TERC Location	MCAM Location

The Predicated Binding Sites between TERC and MCAM
By RIsearch	Structure	TERC Location	MCAM Location	Score

The Predicated Binding Sites of MCAM
RBPBD
RsiteDB
BindN	>sp\|P43121\|MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens GN=MCAM PE=1 SV=2 Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ----+--------------+---------------------++---+---++++-+---- Confidence: 778759979999998667668636232643586799795655646665246676345239 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ------+-+++---+-++++-+++++++--+-+---+--+----+------+----+-++ Confidence: 756473437745346874582867545532675522746857635723376497656399 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: +++++++-+-+-++----------------+++------+---++-+---------+-++ Confidence: 898957964567455445438283475525657352487444484463863894425385 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ++-++++-+-+++++--++--+-----------+--+----------+--++++-+--+- Confidence: 482574847365556427526628336827265567556384868635536554273254 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: -+--------------------+---+-----------------++++++++--+----- Confidence: 657687273539397997886753647626277754223325255689776822623223 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: ----------+++++++-------------------------------+-----++++++ Confidence: 527888833487698592232574963894884686788986936928523222855667 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: -+------+----------------------------++--++-++------+-----+- Confidence: 456252445227658648276462664274684934656435445845427444325262 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: -----------------++---------------++--+++-------+-+++-+---+- Confidence: 266299978785757375573838999859364375228456232723527542534257 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: -+-----------------+-++---+-------------+-+-++++++++++++++++ Confidence: 552947894879864584545452227322898999958453426757886567785866 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: +++++++++++--+--++--------------------------+-+++-++++++--+- Confidence: 896999877864273257666899999999999997899378325396829984762664 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: -++++-------+--+----------+++++++++++--+----+- Confidence: 2659622748586224547989682488779945566335275844 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
BindN+	>sp\|P43121\|MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens GN=MCAM PE=1 SV=2 Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ------------------------------------------------------------ Confidence: 126557679899998979837868388977796877696847397938364737888549 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ----------------+-----------------------------------------+- Confidence: 656464676347574733325244543263262644159287832744544387691933 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: -+---------------------------------------------------------- Confidence: 533433294818255657437274676689584786899776514423962952325535 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ------------------------------------------------------------ Confidence: 545445465723633977668659466758486245438796949653544423433547 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: ------------------------------------------------------------ Confidence: 869586463566576876765555864969686735347527353136522234455324 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: ------------------------------------------------------------ Confidence: 649898956712432645664874854775865888986878867958668685456865 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: ------------------+----------------------------------------- Confidence: 979796775449617525435242343252386833812464677486935544547324 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: ----------------------------------------+------------------- Confidence: 779797948856976783585746476969673623222547634658555744356337 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: ------------------------------------------------------------ Confidence: 774969666537657773818126321534697969748658686454634844446446 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: --------------------------------------------+-+-+++++------- Confidence: 318364275337635452889999979998899998679767313171568731256548 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: ------------+-------------++--++-++-----+---++ Confidence: 5241157768873242688988993543114746621233444465 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
RNAbindR	>P43121\|MCAM Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: -+---------------------------------------------------------- Confidence: 453441200000000002440141220000000000010112122022200121121210 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: ----------------+--------------------------------+-+---+--++ Confidence: 110000112101113251020000001020100000110321032142262714153258 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: -+-+------+--------------------------------++++++++-+++++++- Confidence: 463544213060012201110100010000000000000212055599679269686563 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ----------------------------------------+-++-+-------------- Confidence: 101100000001100100142130032210422211312464661531132242200000 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: ----------------------------------++++--+--+-+-------------- Confidence: 010202112230110001011212121110132356874362253501010000100000 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: -------------++--+++---------------------------------------- Confidence: 001001021133155445564013022301100000000010011121100000000011 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: --------+++++++++++---+------++----+----+-+++--------------- Confidence: 000110435688675576742353113345544036123154555242123011311111 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: -------+-++++++++------------------++++++------------------- Confidence: 110103153775555554214411141121131235576653143211200100012141 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: ---------------------+++------------------------------------ Confidence: 124130211200102214441575322002000000100111000000000000000000 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: -----------------+++-+++----------------++++++++++++++------ Confidence: 000000111100233136763566343311312101101475789799888965423121 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: ---------------+-----------+--++++++++-------+- Confidence: 22224210211013352243210141262488797786424141470 * Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. * Confidence: from level 0 (lowest) to level 9 (highest).
Pprint	Sequence: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV Prediction: ----+---------------------------------------+-----+++------- Confidence: 302030000000000000000000000000000010001201304020303450102020 Sequence: DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR Prediction: +------+++--+---+--+-+--------+--++-++++-+-+-----++++++++-++ Confidence: 331222135432421062143432101100332540564724040002286797939099 Sequence: PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP Prediction: +++++-+-+--------------------------------------+--+--------- Confidence: 496761505010000000000100213110000000000000000024005000030310 Sequence: LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE Prediction: ------------------------------++++-+++++-+---+---++-+-+++++- Confidence: 001002213210132210213110121120647434433804020402356373453453 Sequence: VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN Prediction: -+-----+-----------------------------+-++-+---+++++--------- Confidence: 040202142000000030300200000000200002333673500255544112011200 Sequence: DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS Prediction: -----------+-------------+---+-----------+------------------ Confidence: 000202032124130020102011050214320010101024201010111100000000 Sequence: LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT Prediction: --------+++--+-+--+---+-------+----+--++++++-+-+-++---+-+++- Confidence: 010000013452372300503040021001523024028767382505045233433353 Sequence: QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV Prediction: --------++-------++---------+-------+++++-+----+----------++ Confidence: 110000024402100104410100000050100010443692420014211220022334 Sequence: LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH Prediction: --+-+----+++-+-+---+-++++++++++----------------------------- Confidence: 235173230553340722240677997365400000001000000000000000000000 Sequence: TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL Prediction: -----------------++----+---+---------------++++++++++++++++- Confidence: 000003211112132125432124320510000000000101364499999996634361 Sequence: PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH Prediction: -++----------------------++++++++--++-+---+-+- Confidence: 2351202010000003000021003566766953235131223043 *Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *Confidence: from level 0 (lowest) to level 9 (highest).

Visualization:
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RAID

The Detail Information for This Interaction