| Detail-Interactions: | |
| RAID ID: | RPI00000635 |
|---|---|
| RNA/Protein Symbol 1: | MIR34A(miR-34a) |
| RNA/Protein Category 1: | miRNA |
| RNA/Protein Symbol 2: | TP63(p63) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | Immunoblotting, In Situ Hybridization |
| Tissue: | epidermal cell |
| PMID: | 20090763 |
| Detail description: | p63 directly bound to p53-consensus sites in both miR-34a and miR-34c regulatory regions and inhibited their activity. |
| The Predicated Binding Sites between MIR34A and TP63 | |||||
| By miRanda | Structure | Match Score | Energy Score | MIR34A Location | TP63 Location |
| The Predicated Binding Sites between MIR34A and TP63 | ||||
| By RIsearch | Structure | MIR34A Location | TP63 Location | Score |
| The Predicated Binding Sites of TP63 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|Q9H3D4|P63_HUMAN Tumor protein 63 OS=Homo sapiens GN=TP63 PE=1 SV=1 Sequence: MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD Prediction: ----+++--+-------------------+-++++-+++++++++-+------------- Confidence: 737355933563364752962796337245344552957569665252673689879999 Sequence: FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM Prediction: -----------------------+-+-+--------+----------------------- Confidence: 999899739368797786762334253565847669684635934663643337457225 Sequence: DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS Prediction: -----+++++++++++---+---+-++++-+++++------++--++++-++-------- Confidence: 722525488998766622552236266472755553336244532577627523326572 Sequence: FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV Prediction: --++++++++++-+-+--++-+----+---------+--------+----+++------- Confidence: 635678698465242525677452786253638285433422568684374556548368 Sequence: VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT Prediction: -++---+---+--------------+----++-+------+-+----------------- Confidence: 857542535255734836735226585232554429465656623568435522732672 Sequence: TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR Prediction: -------------++--++----------+--+---++---------+-+-++--+++-+ Confidence: 399558874334466327648489937327357345655438296325392874244558 Sequence: KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES Prediction: +-+-++++++++++++++++++---+-++-+++++----------+-+------------ Confidence: 525376558789689976954522554572989952445892836838233787939465 Sequence: LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ Prediction: ------------+++++++++---------++-++++++++++++-++-++--+--+--- Confidence: 989854855424456968875243365442562887799687866267445326445722 Sequence: LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP Prediction: --+---++--+----------------------------+-++------+--++++-++- Confidence: 664222852252227546466273456248557867336434566245553365652652 Sequence: PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG Prediction: +-+-------+---+---++------+--------------------------+------ Confidence: 525325638956997743444742724255228338555587576272833695489439 Sequence: ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND Prediction: -----------+-++--++++++++-+-++++++--+-----+-+-+---+---+----- Confidence: 797524823434356338467756737267778943676689764752365233655347 Sequence: FNFDMDARRNKQQRIKEEGE Prediction: -------+++++++-+---- Confidence: 97965338989888454465 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|Q9H3D4|P63_HUMAN Tumor protein 63 OS=Homo sapiens GN=TP63 PE=1 SV=1 Sequence: MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD Prediction: -+---++----------+---------+-+-+-+--+----------------------- Confidence: 256324742173336433631676232534144322335542777466374587348956 Sequence: FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM Prediction: ------------------------------------------------------------ Confidence: 998789779786898689997989966898998777275688988986868879999789 Sequence: DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS Prediction: -----------------------------------------------+------------ Confidence: 999988965658878886988998988769478745577353236213363243557172 Sequence: FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV Prediction: --+----++-+---+----+-+-+--++-----+------+----+-----+-------- Confidence: 743211464231253358135355454442619365343141226562341515447276 Sequence: VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT Prediction: -+++-++---------------+--+-+--++--+-------+----------------- Confidence: 846316423517436413633355475311347539553323723538353853864776 Sequence: TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR Prediction: -------------+--+++-------------+---++--+-+-++++++-++----+-+ Confidence: 276556664213541335668399939442654323632334644365481852422635 Sequence: KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES Prediction: ++------+++++++++++-++-----+++++++---------+-++++++--------- Confidence: 341312215656678943623421412887976646768783863858663224427143 Sequence: LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ Prediction: ---------------+-++--+-+--+-+++++++++++-+--++-++------------ Confidence: 568677976547322544421523123234674443543243243333311443765766 Sequence: LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP Prediction: ----+++--------------------------------+--+----------------- Confidence: 673334514735334243455263326436474876243322366488757844326555 Sequence: PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG Prediction: -----------------------------------------------+-++--++--++- Confidence: 333355737836982735267984875358337647846477345264345218535444 Sequence: ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND Prediction: ----+------------+---------------+--+-----+-+-++--+------+-- Confidence: 444443848867642783521123271521222454354566556673135324163435 Sequence: FNFDMDARRNKQQRIKEEGE Prediction: -------+++++++-+---- Confidence: 85466235948667262223 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>Q9H3D4|TP63 Sequence: MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD Prediction: ------+----------+------------------------------------------ Confidence: 142313611312232325023000101200100000000011000001000100000000 Sequence: FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000121001010001000000 Sequence: FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV Prediction: --------+--+--+---++---+--+-----------+-++-+++-------------- Confidence: 000010445035226312552246036213141422425185355714100011120221 Sequence: VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT Prediction: --++-----------------------+--++----------+----------------- Confidence: 146734221110110000023221141633652241001113511000101022110110 Sequence: TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR Prediction: ----------++-++--++------+--+-+-+-++++--++++++++++++-------- Confidence: 001012422365277446511200051164547356772376969999998722200202 Sequence: KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES Prediction: --------++-+-+++-+++-+------+--+++-----------++------------- Confidence: 433224326647468745554542322453475540000000031552443312320210 Sequence: LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ Prediction: ------------------------------------------------------------ Confidence: 010120000000000100000001100110020113312240131000000003102001 Sequence: LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP Prediction: ------------------------------------------------------------ Confidence: 001101000000100000000000000000000000000000000000000000000001 Sequence: PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG Prediction: -------------------------------------------------+++++-+-+-+ Confidence: 000102120011104142021001001210100000000101112212256777464535 Sequence: ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND Prediction: ------------------+--+------+++----+---+--+++-++-----+------ Confidence: 001031000000000012644533132165633435321611767376344145221121 Sequence: FNFDMDARRNKQQRIKEEGE Prediction: -------------------+- Confidence: 110201114032421443350 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD Prediction: +----------------------------------------------------------- Confidence: 432231310000001000000000000000020020003222111000000000000000 Sequence: FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM Prediction: -----------------------+++++-------------------------------+ Confidence: 000000000000000000022027354421321200100000020002000000100113 Sequence: DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS Prediction: ---------------------------------------------------+-++--+-+ Confidence: 222001100210110000000000000000000000000001000000000526531725 Sequence: FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV Prediction: ++++++-+--+--------+---+-+++-+------++++++++-+-----+-------- Confidence: 556545242042001000283225036534110101478648630701122420010321 Sequence: VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT Prediction: -+++++++++-++---+-----+-------------------+---+------------- Confidence: 157676455534422243000030020200230110123312312142211000000000 Sequence: TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR Prediction: --------++++++++-++-----------------++++--+++++++++++-++++++ Confidence: 000010004899868827831200010000003313887700557999998952458835 Sequence: KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES Prediction: +++-++++++++++++----------++++++++-----------+++++++-------- Confidence: 364335556655435422332230135465654320000000032656664310200100 Sequence: LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ Prediction: -------------+-+-+---++--++-+++++++++++++---+--------------- Confidence: 000000000001243434322443233144455454445552225333201223101012 Sequence: LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP Prediction: ------+------------------------+------+--------------------+ Confidence: 000223511011030001322211120112231101213231200000000011020133 Sequence: PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG Prediction: -----------------------------------------------------+--+--- Confidence: 001000000000010001222000000000000000000000000000001103004231 Sequence: ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND Prediction: ++------------------+-------++++++----+---++--+------------- Confidence: 330111010201000000023221222345453411224210433030102000000000 Sequence: FNFDMDARRNKQQRIKEEGE Prediction: -----+++++++++-+---- Confidence: 01110545857545243321 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.