| Detail-Interactions: | |
| RAID ID: | RPI00000449 |
|---|---|
| RNA/Protein Symbol 1: | MIRLET7G(let-7) |
| RNA/Protein Category 1: | miRNA |
| RNA/Protein Symbol 2: | IGF2BP2(IGF2BPs) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | PAR-CLiP, RNA Immunoprecipitation |
| Tissue: | HEK293 cells |
| PMID: | 23069990 |
| Detail description: | however, let-7 microRNAs, |?-catenin (CTNNB1) and MYC have been proposed to be involved in their regulation. In contrast to many other RNA-binding proteins, IGF2BPs are almost exclusively observed in the cytoplasm where they associate with target mRNAs in cytoplasmic ribonucleoprotein complexes (mRNPs). |
| The Predicated Binding Sites between MIRLET7G and IGF2BP2 | |||||
| By miRanda | Structure | Match Score | Energy Score | MIRLET7G Location | IGF2BP2 Location |
| The Predicated Binding Sites between MIRLET7G and IGF2BP2 | ||||
| By RIsearch | Structure | MIRLET7G Location | IGF2BP2 Location | Score |
| The Predicated Binding Sites of IGF2BP2 | |
| RBPBD | RRMx2, KHx4 |
| RsiteDB | |
| BindN |
>sp|Q9Y6M1|IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens GN=IGF2BP2 PE=1 SV=2 Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSG Prediction: ----------+---+----+----------------+--+------------+-----+- Confidence: 885393773842675456955656622735773776535454964675357948732444 Sequence: KVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTET Prediction: +--------------++++++++-+-+---------------------------++-+-- Confidence: 763546297496324599698993657264449669998997843627658335453442 Sequence: AVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQG Prediction: ------+-++---+------+---------+----------++++++++++++++++-++ Confidence: 758372754735467755264532533427574298865525687799479798778275 Sequence: HAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEK Prediction: +-++++++-+------------------------+-++-+++++++-+-+++++++--++ Confidence: 627568884827357929987467867887244555654476656935258445763545 Sequence: PVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKI Prediction: --+---+---++---+-------------------------------+---+--++-++- Confidence: 375726623276255699979853474343885796939896555756653623964774 Sequence: EHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQA Prediction: ---+-++-+-------------++-+-+-+---------------+-------------- Confidence: 323545754533845837223376565644845552957576339548888998885447 Sequence: NLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPH Prediction: --------------+--------+--++--++--------+++-+--+------------ Confidence: 478579382774874256266225326922652432233245626425545454674643 Sequence: HHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITG Prediction: ------------------------++--+-++--+------+------------------ Confidence: 332266479959997458755565673356647775625276553746347373698825 Sequence: PPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTS Prediction: ----+-+-+-+---+-------------+-----+--+++--+---+--++--------- Confidence: 443454554476336727646557345658574856277742944272286424633822 Sequence: AEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK Prediction: ---------++-----------------++-+++-+------+-+++++-++-++++++ Confidence: 84568523254564889893999696826537857738843862555654642467978 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|Q9Y6M1|IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens GN=IGF2BP2 PE=1 SV=2 Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSG Prediction: ---+-+--+--+---------------------+--++++-+-+---------------- Confidence: 352565516753694679969997472833371342476676756564476859846527 Sequence: KVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTET Prediction: ----+-+--+--++--++-+--+-+-++------------------------+-++++-+ Confidence: 334542435452441344254345656734348788997999776547537234534415 Sequence: AVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQG Prediction: ++-+-------------------------------------------------------- Confidence: 443381286499999999786843556235455425445644536833753752552345 Sequence: HAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEK Prediction: ------------------------------+++---+--------+-+--+--------- Confidence: 575454426157488968688347736531654215458655325564534254247882 Sequence: PVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKI Prediction: -----------------------------------------------+-+++++++-+-- Confidence: 794813354436486499999966775674886996958674114324267985853825 Sequence: EHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQA Prediction: ------+-+------------------++----------------------------+-- Confidence: 457447474512767987467826937533655683978898779489898777541423 Sequence: NLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPH Prediction: ------+--------------------+------+----+---------+---------- Confidence: 133221543461633334553354341334226342222322122221241222233232 Sequence: HHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITG Prediction: ----------------------+++++++-+---------------------------+- Confidence: 243466678969565326626234885473616529537251632544244883696732 Sequence: PPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTS Prediction: ----------------------------------+--++-----+++++++-+------- Confidence: 243235384778877938536523447438796434154242124797555274735742 Sequence: AEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK Prediction: ------+------------------------------------------+++-++++++ Confidence: 92717335747668987892812573563585389488958764342113441657878 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>Q9Y6M1|IGF2BP2 Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSG Prediction: ---+-+--+---------------------------++++-------------------- Confidence: 114716136132100000000000012000111002566502000100011021033143 Sequence: KVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTET Prediction: +------------+--++----+-+-++++------------------------------ Confidence: 604242311213463375343474536756440220001100000000000100101000 Sequence: AVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQG Prediction: ------------------------------------------------------------ Confidence: 000001000000001000101000000000000000000000210232211432222121 Sequence: HAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEK Prediction: ---------------------+++++++++++++++++-+++++++-++----------+ Confidence: 002001100000000010011566587788988787962775586839644240333215 Sequence: PVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKI Prediction: ----++--++--+-----------------------------+++-+++++++++++++- Confidence: 111375426522520000011000000130000001020231988489788988886851 Sequence: EHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQA Prediction: ++--+-+++--+--------------------+--------------------------- Confidence: 551463756246121321111110011021245132102310241110111000000020 Sequence: NLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPH Prediction: ------------------------------------------------------------ Confidence: 100000000000001000110021011211110020011013101001011100000000 Sequence: HHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITG Prediction: -------------------+++++++++++++-++--+---+-----------------+ Confidence: 000000000000000234365688988896951683464437134230001001000225 Sequence: PPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTS Prediction: --------------------------------+--+-+++++++++++++++++-++-++ Confidence: 424412411020001000000011001011225145289968878999999795187377 Sequence: AEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK Prediction: ------+-------------------+-+------------------+--+++++++++- Confidence: 343422503011000100001033235353112301100000001145345686789870 Sequence: Prediction: Confidence: *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSG Prediction: ---+-------------------------------------------------------- Confidence: 000312023211000000000000020021001000200100010000100021000011 Sequence: KVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTET Prediction: ------------+-+++++++++-+-++--++---------------------------- Confidence: 310100000203434357654452315532440000000000000000000010000000 Sequence: AVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQG Prediction: ------+--++---------------+------+-------------------++++-++ Confidence: 000303421341020001200020004100100300000000333320012036336365 Sequence: HAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEK Prediction: ++++++++-+-------------+-+++++++++++++++++++-++++++-+++++--+ Confidence: 756899650411000030000034149896999998873754582957563365634105 Sequence: PVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKI Prediction: ------++-+-------------------+-------+----+++-+++++++++++++- Confidence: 000010631432102200000000000025300012080002448235799999998952 Sequence: EHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQA Prediction: ++++--+++++------++----------+--+-++---------+-++-+++----+++ Confidence: 744430743331201313422020000114104254020000000314303552130335 Sequence: NLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPH Prediction: +-------+-++------------------------------------------------ Confidence: 413212123343200001000000000100000000000000000020000000000200 Sequence: HHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITG Prediction: -------------------+++++++++++++-+-++--++-----++++---+------ Confidence: 010000000000000002245899999988940425433833100154432004200000 Sequence: PPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTS Prediction: ----------+---------------------+----+++++++++++++++++-+++++ Confidence: 200100000140002020000031310000003001149968989999999996173564 Sequence: AEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK Prediction: -+++------+----+-----------+++-+----------------+++++-+++++ Confidence: 17550111334302150000000211355516100200000000130297887345545 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.