| Detail-Interactions: | |
| RAID ID: | RPI00000426 |
|---|---|
| RNA/Protein Symbol 1: | MIR7-3(miR-7) |
| RNA/Protein Category 1: | miRNA |
| RNA/Protein Symbol 2: | FOXP3 |
| RNA/Protein Category 2: | Protein |
| Validated Method: | Luciferase Reporter Assay, qRT-PCR |
| Tissue: | BT549 cells, MDA-MB-231 cells, HEK-293T cells |
| PMID: | 21743493 |
| Detail description: | In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3`-UTR of SATB1 to further regulate its expression. |
| The Predicated Binding Sites between MIR7-3 and FOXP3 | |||||
| By miRanda | Structure | Match Score | Energy Score | MIR7-3 Location | FOXP3 Location |
| The Predicated Binding Sites between MIR7-3 and FOXP3 | ||||
| By RIsearch | Structure | MIR7-3 Location | FOXP3 Location | Score |
| The Predicated Binding Sites of FOXP3 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|Q9BZS1|FOXP3_HUMAN Forkhead box protein P3 OS=Homo sapiens GN=FOXP3 PE=1 SV=1 Sequence: MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS Prediction: --+-++++++-++-----+++++++++---+-+-----+-++++-+-+--+-+-++++++ Confidence: 434297697734644442665686658322454454448276682627359352647876 Sequence: LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV Prediction: --+----+-+-----------+--+----------------------+---+-+------ Confidence: 425424256555286997983634954276494867572666556934622447235629 Sequence: HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD Prediction: --------------++-+---+-+-+----------+----------------+++++++ Confidence: 447424748262325547254646782543357276473273287477826525857876 Sequence: STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ Prediction: ++------+++--------+----------------------------+-+--------- Confidence: 754224325453678367644467539799999892695976877623865258636672 Sequence: SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE Prediction: -----------+----------+----+-++-+++++++-------++------++-++- Confidence: 397569987465525638367655542657625875745567665465434537452472 Sequence: APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL Prediction: --------++----++-+++----------------+------------------+++-- Confidence: 425565685535236536646548988973827436744332738926999472455625 Sequence: NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR Prediction: -------------------+-++--+------+---+----+-----------+++++++ Confidence: 249489863978682622543665774353856767764246247469977266799999 Sequence: PSRCSNPTPGP Prediction: +++++++++-- Confidence: 98957746522 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|Q9BZS1|FOXP3_HUMAN Forkhead box protein P3 OS=Homo sapiens GN=FOXP3 PE=1 SV=1 Sequence: MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS Prediction: ++++++++++--------+++++++++---+-------+-++++++-+--+++-+--+++ Confidence: 357596476322144433654364568323531343366145544527128552421553 Sequence: LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV Prediction: ------++-------------+--+----------------------------------- Confidence: 412312463166464664852533645333382577453446422963964353654738 Sequence: HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD Prediction: -----------------------+-+----------------------------+--++- Confidence: 548576789666842451265225452343443165374263376767756312311444 Sequence: STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ Prediction: ++-------------+---+---------------+--+--+----+++-+-+------- Confidence: 435576332212525323251225538998737784253273234476546446452363 Sequence: SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE Prediction: ---------------------------------------------------------+-- Confidence: 264457737573723648368615742374463252222356553521226536224312 Sequence: APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL Prediction: -----+--++--+-+---------------------+--++----------+---++--- Confidence: 321124236312334332236465635534722153511441646945783433254435 Sequence: NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR Prediction: --------------+-+-++-+++-+-----+----+--+-++--------+-+++++++ Confidence: 126678958547117162462554571231541523821618821125343334567879 Sequence: PSRCSNPTPGP Prediction: +++++++++++ Confidence: 87978758657 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>Q9BZS1|FOXP3 Sequence: MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS Prediction: --+-++--------------------+-----------++++++---------------- Confidence: 148295244311110021333122346211301202345567552312013100000011 Sequence: LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV Prediction: ------------------------------------------------------------ Confidence: 020002020200110000000100402312211000000000011000000000110040 Sequence: HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD Prediction: ------------------------------------------------------------ Confidence: 111102000103211000000101011311420210000000000001010111211200 Sequence: STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ Prediction: ----------+----+---+-+------------------------+++----------- Confidence: 000000011152324542464543120000000001200012211465513141212222 Sequence: SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE Prediction: ----+------------------------------------------------------- Confidence: 331171121134020100100000000100000000000000000000100000001012 Sequence: APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL Prediction: ---------------------------------------++------------------- Confidence: 002223244433232220000000000000000011344553432122100013124122 Sequence: NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR Prediction: ---------------+--+-++++++++-+-++------+-+++-+---------++-++ Confidence: 322322112231234534638665566645365222304517753620110112277165 Sequence: PSRCSNPTPGP Prediction: --+++++++++- Confidence: 135556889680 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS Prediction: --+++--+--------------------------+--++--+++---+--++++++-+-- Confidence: 234452242220000000000022000001100332334336662235136546732321 Sequence: LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV Prediction: --+------------------------+-------------------------------- Confidence: 114311010000000000002311203411100000000100010022030210010000 Sequence: HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD Prediction: ------------------------------+--------------------++-+++-++ Confidence: 330010000000000000000102032102410000100000000000000343463344 Sequence: STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ Prediction: +-+------------+-----+-------------------+----+-+-+++-++---- Confidence: 323122120122000303130332020000000000200004100133505540441001 Sequence: SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE Prediction: ----------------+------------------------------------------- Confidence: 000000000000000141310000000000000000000000000000000000000020 Sequence: APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL Prediction: --------+-------+------------+---+++++---+--------+-+++-++-- Confidence: 002122314231113242100000022013122334753234000000024166336622 Sequence: NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR Prediction: -----------+--+++++++++++++++++++++++-+++++-----------++++++ Confidence: 200000000204305464987999975768869994625969933100000101499779 Sequence: PSRCSNPTPGP Prediction: +++++++++++ Confidence: 99999997556 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.