| Detail-Interactions: | |
| RAID ID: | RPI00000410 |
|---|---|
| RNA/Protein Symbol 1: | PVT1(pvt1) |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | YY1 |
| RNA/Protein Category 2: | Protein |
| Validated Method: | Real time qPCR |
| Tissue: | prostate cancer cell |
| PMID: | 21814516 |
| Detail description: | The risk allele (G) of rs378854 reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected. |
| The Predicated Binding Sites between PVT1 and YY1 | |||||
| By miRanda | Structure | Match Score | Energy Score | PVT1 Location | YY1 Location |
| The Predicated Binding Sites between PVT1 and YY1 | ||||
| By RIsearch | Structure | PVT1 Location | YY1 Location | Score |
| The Predicated Binding Sites of YY1 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|P25490|TYY1_HUMAN Transcriptional repressor protein YY1 OS=Homo sapiens GN=YY1 PE=1 SV=2 Sequence: MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHG Prediction: --+------------------------------------------------------++- Confidence: 754642627525623658799798785962538428325785366668877666323462 Sequence: GGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDG Prediction: ++-++-+--+-------------------------+------------+--------++- Confidence: 552572633533234445556779995788265525635879987833465664674653 Sequence: LRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKS Prediction: -+-----------------------------------++++++++++++++-++++++++ Confidence: 477347799799969673434466398478927644299899899999889299998999 Sequence: GKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE Prediction: +++++-+------++++++++++++++++-+-+------------+--++---------- Confidence: 999673724522254555776888546556666254647373742534565646879999 Sequence: QIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPH Prediction: ------++--++-+-+-++-++------------------+-++++-+-----+------ Confidence: 898753642265352536645544645857236237536685848755232436355342 Sequence: KGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGC Prediction: +--++--+--+--+++-+++--+--------+----+++-++----+---+--------- Confidence: 623773466254286645763297375777675262579387325653546242737522 Sequence: GKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ Prediction: -++-------+---+-++--+-+--------+++-++++-++---+--+-++++ Confidence: 456536354653257566326447758544256447777375377425739655 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|P25490|TYY1_HUMAN Transcriptional repressor protein YY1 OS=Homo sapiens GN=YY1 PE=1 SV=2 Sequence: MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHG Prediction: ------------------------------------------------------------ Confidence: 552998979967755758999586895884859889989998999999999988985423 Sequence: GGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDG Prediction: ---++-+-----+--++-----------------+------------------------- Confidence: 211441322313421442347856697889665641422558887957499999987558 Sequence: LRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKS Prediction: -------------------------------------------++----+++++++++++ Confidence: 969989799799778535888898698898979988933222244221237487555878 Sequence: GKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE Prediction: ++++----------------++-++--+-------------------------------- Confidence: 756338367677544545233417621425554375656665834444223553527455 Sequence: QIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPH Prediction: -----+--+++++++++++--------------+------+-++++-+++++++------ Confidence: 368643114464456656711222433645552544222472637718446345125263 Sequence: KGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGC Prediction: ---+++++-++--+-+-++++++--------+--+++++-+-+-+-+++++--------- Confidence: 342675351561171526575481284644141133555261414175655114454651 Sequence: GKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ Prediction: +++-+-++--+-+-+-+++++-+-------+++++++++++-+-++++++++++ Confidence: 464142431271517176666136475651575445765471624585858575 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>P25490|YY1 Sequence: MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHG Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000110000000000000000000000000000 Sequence: GGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDG Prediction: ------------------------------------------------------------ Confidence: 000000000000000001001011102100020011000000000000000000000000 Sequence: LRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKS Prediction: -------------------------------------------++++++++-+-++++-+ Confidence: 000000000000000000000000000000000001311221256666776363655648 Sequence: GKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE Prediction: ++++----------------+--+---++---+--+++---------------------- Confidence: 566643423211111244325335422651326445653422121101110110000000 Sequence: QIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPH Prediction: ----------------+++-+-+-------++-++++---+-++++-+-+-++++--+-+ Confidence: 000002414423303455836451424231674875644263566728464579744625 Sequence: KGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGC Prediction: -++++++++-++-++++++++++++++-+++++++++++-+++++++++++++++-+-++ Confidence: 157898698469379868998697787388898897788488968899999887625267 Sequence: GKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ Prediction: +++++++++-+++++++++++++++----+++++++-+++++++++++++++++- Confidence: 7997986794878698999999856131475987994896999899999999990 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHG Prediction: -----------------------------------------------------+++++++ Confidence: 222310000000010000000000000000000000000000000000002135879999 Sequence: GGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDG Prediction: ++++++++++++++++++++-----------------------------------+-++- Confidence: 999999999999999776653220000000000000110000000000100000051443 Sequence: LRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKS Prediction: -+-----------------------------------+---+--+-+-+-+-++++++++ Confidence: 130011000000000100012020000000000000132214334251435274777785 Sequence: GKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE Prediction: +++-+++-+++----+-+---++-----+-----------------+-+----------- Confidence: 587243434440011323120430000330101000000100011051322000000002 Sequence: QIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPH Prediction: --------+++++++++++++-++++--+--+++++++++++++++++++++++++++-- Confidence: 010001337697974797766367983042348564544798789987567536765521 Sequence: KGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGC Prediction: -++++++++++++++++++++++++-++--+++++++++++++++++++++++-----++ Confidence: 255696586556848999988999925531896897777769999798989932200056 Sequence: GKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ Prediction: +++++++++++++++++++++++++---++++++++++++++++++++++++++ Confidence: 796899868779999899989964410066899999959769999699999989 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.