Detail-Interactions: | |
RAID ID: | RPI00000409 |
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RNA/Protein Symbol 1: | MEG3 |
RNA/Protein Category 1: | lncRNA |
RNA/Protein Symbol 2: | TRP53(P53) |
RNA/Protein Category 2: | Protein |
Validated Method: | |
Tissue: | pituitary adenoma cell line |
PMID: | 22393162 |
Detail description: | A major focus of our research is the molecular pathogenesis of human pituitary adenomas. Re-expression of meg3 inhibits tumor cell proliferation in culture and colony formation in soft agar. Maternal deletion of the Meg3 gene in mice results in skeletal muscle defects and perinatal death. Inactivation of Meg3 leads to a significant increase in expression of angiogenesis-promoting genes and microvessel formation in the brain. These lines of evidence strongly suggest that MEG3 functions as a novel lncRNA tumor suppressor. MEG3 induces accumulation of p53 (TP53) protein, stimulates transcription from a p53-dependent promoter, and selectively regulates p53 target gene expression. |
The Predicated Binding Sites between and | |||||
By miRanda | Structure | Match Score | Energy Score | Location | Location |
The Predicated Binding Sites between and | ||||
By RIsearch | Structure | Location | Location | Score |
The Predicated Binding Sites of TRP53 | |
RBPBD | |
RsiteDB | |
BindN | |
BindN+ | |
RNAbindR | |
Pprint |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.