| Detail-Interactions: | |
| RAID ID: | RPI00000383 |
|---|---|
| RNA/Protein Symbol 1: | TERC(htr) |
| RNA/Protein Category 1: | snoRNA |
| RNA/Protein Symbol 2: | PCNA |
| RNA/Protein Category 2: | Protein |
| Validated Method: | |
| Tissue: | hepatocellular carcinoma cell line HepG2 |
| PMID: | 17932748 |
| Detail description: | HepG2 cells transfected with the antisense hTR gene showed down-regulated telomerase activity, inhibited cell growth, decreased PCNA expression, and increased apoptotic rate. |
| The Predicated Binding Sites between TERC and PCNA | |||||
| By miRanda | Structure | Match Score | Energy Score | TERC Location | PCNA Location |
| The Predicated Binding Sites between TERC and PCNA | ||||
| By RIsearch | Structure | TERC Location | PCNA Location | Score |
| The Predicated Binding Sites of PCNA | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|P12004|PCNA_HUMAN Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 Sequence: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY Prediction: ------------+-------------------+--+-+---+----------+----+-+ Confidence: 898928825368639869939995898779226246452534327369273772222525 Sequence: RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD Prediction: +--+---------+-++--+----------+------------------+---------- Confidence: 642837654835255557763675765727584437638999867423466255683986 Sequence: LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI Prediction: -----------------+--+----+--+--------------+---+---+----+-+- Confidence: 979858775555327765634436568667945987898835653366524442426465 Sequence: KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK Prediction: +--++++--+-------------------+------+-++-+++-+-------------- Confidence: 842647742576478396866895936884483654455548566563638797899974 Sequence: IADMGHLKYYLAPKIEDEEGS Prediction: --------------------- Confidence: 995663823388328666463 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|P12004|PCNA_HUMAN Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 Sequence: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY Prediction: -------+-----------------------------------+---------------- Confidence: 474916736299439956939994696899455662935522253718194925986986 Sequence: RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD Prediction: -------------------+--+------------------------------------- Confidence: 386259654626325427672343553749388789879898956622424455783988 Sequence: LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI Prediction: --------------------+-------+------------------------------- Confidence: 899999897686469593723446417855975998795957454582726468732826 Sequence: KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK Prediction: --------------------------------+---+--+-------------------- Confidence: 473235478799999899998992943472263486762463559493633385949775 Sequence: IADMGHLKYYLAPKIEDEEGS Prediction: --------------------- Confidence: 994551865287539889675 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>P12004|PCNA Sequence: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY Prediction: ----+--+-+--++-----------------------+--+++++---+----------+ Confidence: 424160263521680041021002102100201203062468685411511142112225 Sequence: RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD Prediction: +--++---+++-++--+--+---+------------------------------------ Confidence: 632661326772661361184135424111400000000000011132120000001001 Sequence: LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI Prediction: ---------------------++------+-------------------+---+-+---- Confidence: 000010001110000012333652231145044112301200113424452425052122 Sequence: KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK Prediction: --------------------------+--+--+---+-+++--+---------------- Confidence: 404332111200000000002113247225425422846561372411112123010111 Sequence: IADMGHLKYYLAPKIEDEEGS Prediction: -------+++--++-------- Confidence: 0042232657235501100100 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY Prediction: ---------+-----------------------+++-+-+++++---------------- Confidence: 103010010300100000000000000000000837190368992010000010000000 Sequence: RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD Prediction: ------+-+---+++++-+++-+++++---------------------+++++++-+--- Confidence: 100200526130596692488399964010200000000002020022534453506013 Sequence: LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI Prediction: -------------------------+-----------------------+----++--+- Confidence: 000000000000000000000000260000000000000010000000050102333030 Sequence: KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK Prediction: --+-----------------------++--------+-++-------------------+ Confidence: 104110100000000000002001225401300000305510010002210000000005 Sequence: IADMGHLKYYLAPKIEDEEGS Prediction: -----+-+-+---+-----++ Confidence: 003003040400140100045 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.