| Detail-Interactions: | |
| RAID ID: | RPI00000048 |
|---|---|
| RNA/Protein Symbol 1: | MEG3 |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | GDF15 |
| RNA/Protein Category 2: | Protein |
| Validated Method: | |
| Tissue: | |
| PMID: | 21400503 |
| Detail description: | Maternally expressed gene 3 (MEG3) is a maternally expressed imprinted gene representing a large noncoding RNA in which microRNAs (miRNAs) and small nucleolar RNAs are also hosted. It is capable of interacting with cyclic AMP, p53, murine double minute 2 (MDM2) and growth differentiation factor 15 (GDF15) playing a role in cell proliferation control. |
| The Predicated Binding Sites between MEG3 and GDF15 | |||||
| By miRanda | Structure | Match Score | Energy Score | MEG3 Location | GDF15 Location |
| The Predicated Binding Sites between MEG3 and GDF15 | ||||
| By RIsearch | Structure | MEG3 Location | GDF15 Location | Score |
| The Predicated Binding Sites of GDF15 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|Q99988|GDF15_HUMAN Growth/differentiation factor 15 OS=Homo sapiens GN=GDF15 PE=1 SV=3 Sequence: MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY Prediction: ------+--+-------------------------++-+----++-+-++++-++-+++- Confidence: 755326725442378899999559746567246364946234255552445757728553 Sequence: EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL Prediction: -+---+-+-++++-------------+--+---+--+--+---+--+----------++- Confidence: 354536773645523223457365677764446754533542757286764565535687 Sequence: HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL Prediction: -+---+-+-+-++++--++--++--+--+--------+-+++++++------+++-+--- Confidence: 295486762625757256824872453474242372957655676432447457829227 Sequence: ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC Prediction: ----+-+++++++++++++---------+--+--+-+----------------------- Confidence: 364863557979998969543253542393294266862976986975893725739488 Sequence: IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL Prediction: -----++-+--------+++-++-+--+---------------------+--+------- Confidence: 866536467442524375574583734463746573622466979332372455234867 Sequence: LAKDCHCI Prediction: -------- Confidence: 79589589 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|Q99988|GDF15_HUMAN Growth/differentiation factor 15 OS=Homo sapiens GN=GDF15 PE=1 SV=3 Sequence: MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY Prediction: ------+--+-------------------------------------------------- Confidence: 224238628552268689777546428858877674362567943722663295754322 Sequence: EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL Prediction: -------+-+------------------------------------------------+- Confidence: 275842843361239366778655771873836256234265639439989575357438 Sequence: HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL Prediction: -+---+-+---++--------+----------------------+-----------+--- Confidence: 644565445233327572245332526623253533928422226255666572253635 Sequence: ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC Prediction: ------+++++++++++-+---------+-++----+---------------+------- Confidence: 674924434989987851331242475332442356553833853862345332248567 Sequence: IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL Prediction: --------+--+------+--+--+--------+-----+---------------+---- Confidence: 525432266365312174423413335135322433222334378544512744232337 Sequence: LAKDCHCI Prediction: -----+-- Confidence: 78733512 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>Q99988|GDF15 Sequence: MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY Prediction: ---++-++++-------------------------------------------------- Confidence: 243773857614200100000020111110000000000000000000000000000010 Sequence: EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL Prediction: -----------------------------------+++--------------+-----+- Confidence: 000001010200000010203110133002142335561432040130014361321160 Sequence: HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL Prediction: ---------------+-+----++-+--+--------+---------------------+ Confidence: 122012221443233505421456261252212211263344433221011122224445 Sequence: ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC Prediction: --+++++++++++++++++++++++++++++++++-++--+------+---------+-- Confidence: 447678899999999999999998999999998974954153044225301310220621 Sequence: IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL Prediction: ------+-++++++---+---+--+----+++++-+---+----------+---++---- Confidence: 112144727859774315141541542435667725431600100000125101652231 Sequence: LAKDCHCI Prediction: --+-+++-- Confidence: 116257820 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY Prediction: ------+-----------------------------------------------+--++- Confidence: 323212421221200000000000120000000000102000201001102101522450 Sequence: EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL Prediction: ----++++----+----------------------++-++++---++--------+-++- Confidence: 010055352230500120010000001000000234523654220452001311243440 Sequence: HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL Prediction: --------+++++-++-+++++++++++-+-+--------++++---------------- Confidence: 132012034547405629947999786324342221021054532201120010212121 Sequence: ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC Prediction: ----+++++++++++++++++++++++++++-----+----------------------+ Confidence: 332288999999999999999887697856322010600000001000000200000003 Sequence: IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL Prediction: +---------++-++--+++-+----+++++++---------------------+----- Confidence: 610010002047376005443832213447755102000200010000002001620210 Sequence: LAKDCHCI Prediction: ------++ Confidence: 00122245 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.