| Detail-Interactions: | |
| RAID ID: | RPI00000044 |
|---|---|
| RNA/Protein Symbol 1: | XIST(Xist) |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | EZH2(Ezh2) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | Mass spectrometry, RNA RNP Immunoprecipitation |
| Tissue: | |
| PMID: | 21123648 |
| Detail description: | Ezh2 interacts with HOTAIR and Xist. |
| The Predicated Binding Sites between XIST and EZH2 | |||||
| By miRanda | Structure | Match Score | Energy Score | XIST Location | EZH2 Location |
| The Predicated Binding Sites between XIST and EZH2 | ||||
| By RIsearch | Structure | XIST Location | EZH2 Location | Score |
| The Predicated Binding Sites of EZH2 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|Q15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens GN=EZH2 PE=1 SV=2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: --++++++++-+---+++-++++-+-++-++-++----+---++++++--------+--- Confidence: 436769976725342669388673765537736632266332676547365364854333 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: ++++----------++++-++-++------------------------------------ Confidence: 655662274863244658367246624464664476382272577284764433475669 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----------------------------------+----+------------------- Confidence: 999996895597389889899983795799263437424456656979999999957652 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------++-+-+--+--+--++++++++++--------------+-+---- Confidence: 335566776755433543524444435327788769945244966994246434564233 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: +---+----------------------+-++-++-++-----+---++--+--------- Confidence: 652252634547457644452437222739826734463485466966674479899895 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: -++++++++++++----+---+----------------+--+-+++++++++++++++++ Confidence: 645789999766525635332526245856728857775528488879999999989799 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: +++++++--------+++++-++--++++++++-+-+--++-+++++++++++-+++-+- Confidence: 898988822625733658863742245655576262422652676879967783676455 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: +-------------------+--------------+---+++-+-----+---------- Confidence: 533654775844447452685987622473789896544677383535859234387637 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: ------+++++++++++------++-+-++++++++-+--------+----+-------- Confidence: 473352668999999784246286736487558766343444323372232525548995 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: ----------+----+-++-+-+-+-++++---+---+-------------------+-+ Confidence: 678757736262322644638382827776326587956677797837666433322557 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -++-+-++++++----------------------------------------++-+-+-- Confidence: 365354795875354795458665897935573245574879749834522376272553 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: -----------------++++++-+--------+-+----------+-----++--+--- Confidence: 487399859779988565897984745233622444728766368468655846555275 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ------+--+----+----------- Confidence: 88798743254357426686288796 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|Q15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens GN=EZH2 PE=1 SV=2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: --++++++++-+-+++++-++++++-++++++++----+----+++-------------- Confidence: 214658764317246676288574838649846513674353234322377477982852 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: +--+-------------+--+-----------------+--+-----+---+-------- Confidence: 341564272884431325644774986676363365385145557483331411444237 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: ---------+--+-----------------++--++-+--+------------------- Confidence: 787893663562624666688783794469332448261433556958895988726652 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------+---------++--+++++-++----------------------- Confidence: 346777778444132434142463335225455328522243865883437431324263 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: +-+++---------------+-+-+++++++-++-+------+---++--+--------- Confidence: 554543424249426673554354534757826643274264432585253355372331 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: ---+-++-+-------------+-+------+-----------++-+++++++++-+--+ Confidence: 422414426157369955231134423623656556793951644248878888825413 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: ---+------+----+-------------------------------+------------ Confidence: 211434431744652465746184237568824747788667735424352225234657 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: -----------+--------------+--+-----+----++++---------------- Confidence: 363978852854247544993884744414234593634274353232557477198948 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: ------++++++++++++++++-++-+-++---++------------+------------ Confidence: 655262778999999893754536524435421441525657533324133435557996 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: --------------------+--------------------------------------+ Confidence: 669775778658747373255233477436585368947577788898668735533225 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -++-+-+++++-+------++++---+----------------------------+---- Confidence: 366132664362376461143441364722662456569847688947554532532385 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: ------------------++-+--++-+++---+------------+------+------ Confidence: 459658549779989662552822745654221774838743525354552415232177 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ------+------------------- Confidence: 56368444649899645287374773 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>Q15910|EZH2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: -----+++++-++++++++++++++++++++++++++-+--+-+++-+------------ Confidence: 000246785546587998787775879979989997737447259626201301012003 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: --------+--------------------------------------++--+--+---+- Confidence: 101402325030321222011100011111121331002001012236543622532251 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----+--++-++---------------------------+------------------- Confidence: 111025227838710100000000000000000000013152321012000010001001 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ------------------------------------------------------------ Confidence: 100000000000000000000000000000000000010011000001112121010110 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: -----------------------------------------------+------------ Confidence: 101000010000000000100000000101000100000302032145102011102112 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: ------------------+---+--------------------------+--+++++-++ Confidence: 021113411100000012534373241321121011101123112311454488677466 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: ------------------------------------------------------------ Confidence: 313321110010001101000020000000000000000000000000000021110011 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: ---------+--+---------------++-+-------+++--+--------------- Confidence: 001000103524621110002100321177482213223588437314400100000000 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: -------+--+++++++++++++++++-+-------------+-+-------+--+-++- Confidence: 000000153468868888987877667363242021013033536424321474264553 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: --+-++--+-++---++++++++++++++++++++-+++-+-+-++++---------+-+ Confidence: 245477226165444768678896989888776883585464626986410100113535 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -+--+-++++++++-++++++++++-+---------------+----------------- Confidence: 352473579787764558688989528113104110111342521110230013002110 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: ---------------+-+++++--++-+++++++++-+-+-+++++++++++-------- Confidence: 323331030013221548866934972898788867374546867897757514241121 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ----+++-------------+------ Confidence: 122265633100001312135112230 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: ++++++-+++++++++-+++-++++-++++++++----+--+------------------ Confidence: 457554344649476616443773538546756531014203002302100101013000 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: ---+---++-------+++----------------------------------------- Confidence: 001631134221000246422100000100000110001121000000000000000000 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----------------------------------+------------------------ Confidence: 000000000000200100000000000000010024220022000000000000000213 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------+--------------++-++------------------------- Confidence: 010000000000011300102313211133343363221120000000020100100000 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: ---------------------------+++++-+-------------------------+ Confidence: 000000000100000000000120003447632321021110200000010010100036 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: +++++++++++----------------------------------+-+++++++++++++ Confidence: 457754865543010100021210010100120011000001012424755577758546 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: +++------------------+++++-+-+-++-+---------+-+++-+-----+--- Confidence: 334222222000001113231545553534236241100110103234314230114012 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: ----+------------------------------------------------++---+- Confidence: 201140013220200211000000012010001000010132321301120324322132 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: +--+++++++++++++++++++++++++++-+++--------+-+-+--++++------- Confidence: 512465999998998688658643745585244301100011304243365461200000 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: ----+----+-++++++-+-+++-+++++++--+------------------+---++++ Confidence: 000032030304556543405341557677422700100000000000021242235667 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: +++++++++++-+--+-++++++++++-+-+----------------------------- Confidence: 886887864832412414659999599141430000000000000000000002000113 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: -+---------------+++++++++++++++++++---------++--+---++----- Confidence: 130301010000000006537995997999975746000001002592162004400000 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: -------------------------- Confidence: 00000000000300000000220011 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.