Detail-Interactions: | |
RAID ID: | RPI00000040 |
---|---|
RNA/Protein Symbol 1: | HOTAIR |
RNA/Protein Category 1: | lncRNA |
RNA/Protein Symbol 2: | EZH2 |
RNA/Protein Category 2: | Protein |
Validated Method: | |
Tissue: | |
PMID: | 21278485 |
Detail description: | CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST. |
The Predicated Binding Sites between HOTAIR and EZH2 | |||||
By miRanda | Structure | Match Score | Energy Score | HOTAIR Location | EZH2 Location |
The Predicated Binding Sites between HOTAIR and EZH2 | ||||
By RIsearch | Structure | HOTAIR Location | EZH2 Location | Score |
The Predicated Binding Sites of EZH2 | |
RBPBD | |
RsiteDB | |
BindN |
>sp|Q15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens GN=EZH2 PE=1 SV=2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: --++++++++-+---+++-++++-+-++-++-++----+---++++++--------+--- Confidence: 436769976725342669388673765537736632266332676547365364854333 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: ++++----------++++-++-++------------------------------------ Confidence: 655662274863244658367246624464664476382272577284764433475669 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----------------------------------+----+------------------- Confidence: 999996895597389889899983795799263437424456656979999999957652 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------++-+-+--+--+--++++++++++--------------+-+---- Confidence: 335566776755433543524444435327788769945244966994246434564233 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: +---+----------------------+-++-++-++-----+---++--+--------- Confidence: 652252634547457644452437222739826734463485466966674479899895 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: -++++++++++++----+---+----------------+--+-+++++++++++++++++ Confidence: 645789999766525635332526245856728857775528488879999999989799 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: +++++++--------+++++-++--++++++++-+-+--++-+++++++++++-+++-+- Confidence: 898988822625733658863742245655576262422652676879967783676455 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: +-------------------+--------------+---+++-+-----+---------- Confidence: 533654775844447452685987622473789896544677383535859234387637 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: ------+++++++++++------++-+-++++++++-+--------+----+-------- Confidence: 473352668999999784246286736487558766343444323372232525548995 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: ----------+----+-++-+-+-+-++++---+---+-------------------+-+ Confidence: 678757736262322644638382827776326587956677797837666433322557 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -++-+-++++++----------------------------------------++-+-+-- Confidence: 365354795875354795458665897935573245574879749834522376272553 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: -----------------++++++-+--------+-+----------+-----++--+--- Confidence: 487399859779988565897984745233622444728766368468655846555275 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ------+--+----+----------- Confidence: 88798743254357426686288796 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
BindN+ |
>sp|Q15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens GN=EZH2 PE=1 SV=2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: --++++++++-+-+++++-++++++-++++++++----+----+++-------------- Confidence: 214658764317246676288574838649846513674353234322377477982852 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: +--+-------------+--+-----------------+--+-----+---+-------- Confidence: 341564272884431325644774986676363365385145557483331411444237 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: ---------+--+-----------------++--++-+--+------------------- Confidence: 787893663562624666688783794469332448261433556958895988726652 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------+---------++--+++++-++----------------------- Confidence: 346777778444132434142463335225455328522243865883437431324263 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: +-+++---------------+-+-+++++++-++-+------+---++--+--------- Confidence: 554543424249426673554354534757826643274264432585253355372331 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: ---+-++-+-------------+-+------+-----------++-+++++++++-+--+ Confidence: 422414426157369955231134423623656556793951644248878888825413 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: ---+------+----+-------------------------------+------------ Confidence: 211434431744652465746184237568824747788667735424352225234657 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: -----------+--------------+--+-----+----++++---------------- Confidence: 363978852854247544993884744414234593634274353232557477198948 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: ------++++++++++++++++-++-+-++---++------------+------------ Confidence: 655262778999999893754536524435421441525657533324133435557996 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: --------------------+--------------------------------------+ Confidence: 669775778658747373255233477436585368947577788898668735533225 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -++-+-+++++-+------++++---+----------------------------+---- Confidence: 366132664362376461143441364722662456569847688947554532532385 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: ------------------++-+--++-+++---+------------+------+------ Confidence: 459658549779989662552822745654221774838743525354552415232177 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ------+------------------- Confidence: 56368444649899645287374773 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
RNAbindR |
>Q15910|EZH2 Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: -----+++++-++++++++++++++++++++++++++-+--+-+++-+------------ Confidence: 000246785546587998787775879979989997737447259626201301012003 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: --------+--------------------------------------++--+--+---+- Confidence: 101402325030321222011100011111121331002001012236543622532251 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----+--++-++---------------------------+------------------- Confidence: 111025227838710100000000000000000000013152321012000010001001 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ------------------------------------------------------------ Confidence: 100000000000000000000000000000000000010011000001112121010110 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: -----------------------------------------------+------------ Confidence: 101000010000000000100000000101000100000302032145102011102112 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: ------------------+---+--------------------------+--+++++-++ Confidence: 021113411100000012534373241321121011101123112311454488677466 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: ------------------------------------------------------------ Confidence: 313321110010001101000020000000000000000000000000000021110011 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: ---------+--+---------------++-+-------+++--+--------------- Confidence: 001000103524621110002100321177482213223588437314400100000000 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: -------+--+++++++++++++++++-+-------------+-+-------+--+-++- Confidence: 000000153468868888987877667363242021013033536424321474264553 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: --+-++--+-++---++++++++++++++++++++-+++-+-+-++++---------+-+ Confidence: 245477226165444768678896989888776883585464626986410100113535 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: -+--+-++++++++-++++++++++-+---------------+----------------- Confidence: 352473579787764558688989528113104110111342521110230013002110 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: ---------------+-+++++--++-+++++++++-+-+-+++++++++++-------- Confidence: 323331030013221548866934972898788867374546867897757514241121 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: ----+++-------------+------ Confidence: 122265633100001312135112230 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
Pprint |
Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW Prediction: ++++++-+++++++++-+++-++++-++++++++----+--+------------------ Confidence: 457554344649476616443773538546756531014203002302100101013000 Sequence: KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF Prediction: ---+---++-------+++----------------------------------------- Confidence: 001631134221000246422100000100000110001121000000000000000000 Sequence: MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ Prediction: -----------------------------------+------------------------ Confidence: 000000000000200100000000000000010024220022000000000000000213 Sequence: YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL Prediction: ---------------+--------------++-++------------------------- Confidence: 010000000000011300102313211133343363221120000000020100100000 Sequence: KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH Prediction: ---------------------------+++++-+-------------------------+ Confidence: 000000000100000000000120003447632321021110200000010010100036 Sequence: ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN Prediction: +++++++++++----------------------------------+-+++++++++++++ Confidence: 457754865543010100021210010100120011000001012424755577758546 Sequence: NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM Prediction: +++------------------+++++-+-+-++-+---------+-+++-+-----+--- Confidence: 334222222000001113231545553534236241100110103234314230114012 Sequence: KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA Prediction: ----+------------------------------------------------++---+- Confidence: 201140013220200211000000012010001000010132321301120324322132 Sequence: PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ Prediction: +--+++++++++++++++++++++++++++-+++--------+-+-+--++++------- Confidence: 512465999998998688658643745585244301100011304243365461200000 Sequence: NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS Prediction: ----+----+-++++++-+-+++-+++++++--+------------------+---++++ Confidence: 000032030304556543405341557677422700100000000000021242235667 Sequence: CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK Prediction: +++++++++++-+--+-++++++++++-+-+----------------------------- Confidence: 886887864832412414659999599141430000000000000000000002000113 Sequence: YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE Prediction: -+---------------+++++++++++++++++++---------++--+---++----- Confidence: 130301010000000006537995997999975746000001002592162004400000 Sequence: ELFFDYRYSQADALKYVGIEREMEIP Prediction: -------------------------- Confidence: 00000000000300000000220011 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.