| Detail-Interactions: | |
| RAID ID: | RPI00000034 |
|---|---|
| RNA/Protein Symbol 1: | Six3OS |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | EYA4(Eya4) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | RNA RNP Immunoprecipitation |
| Tissue: | |
| PMID: | 21936910 |
| Detail description: | Ezh2 and Eya1/3/4 directly bind Six3OS. |
| The Predicated Binding Sites between Six3OS and EYA4 | |||||
| By miRanda | Structure | Match Score | Energy Score | Six3OS Location | EYA4 Location |
| The Predicated Binding Sites between Six3OS and EYA4 | ||||
| By RIsearch | Structure | Six3OS Location | EYA4 Location | Score |
| The Predicated Binding Sites of EYA4 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|O95677|EYA4_HUMAN Eyes absent homolog 4 OS=Homo sapiens GN=EYA4 PE=1 SV=2 Sequence: MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSS Prediction: -------+--+-+++-++---++++++++----------------+++++++-++++-++ Confidence: 777537543355876445225587888954363585263267323487788925968368 Sequence: TSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTF Prediction: ++-+++-++----------------+++++-+------++-+-++-+++-++-------- Confidence: 774777275223528834984873646588354356786425374267636634236626 Sequence: TGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTA Prediction: +-+--++++++++++++++-+-++++-------+---++-+-+--+++++-------++- Confidence: 445576785877986766535364564222772524365354732745672532357642 Sequence: YSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQM Prediction: ++++++-++-------------+++++-++++++-++---++++--+++++++++++++- Confidence: 768758276432478698845554575277666444632645552267576687575542 Sequence: PGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTA Prediction: --+++-++++-+-+++-+++++++++++++-++----+-++-++++-+++--+-+++-+- Confidence: 235652566746554626565647576657246232453463455636672263644272 Sequence: DGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRGRGRKNNP Prediction: ++++++++++---------+-------+-+++++--+----++-++++++++++++++++ Confidence: 467788876626354643452234263545556627526455529999999999999998 Sequence: SPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTH Prediction: ++--++---+-------------------++-+++-+------+---+------------ Confidence: 872346375598989999899997579237738973834247856575986999799855 Sequence: LFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRK Prediction: ------------------+-------+++---+-------++---------+------+- Confidence: 989899989759496472524222345453664687255466424674245833564852 Sequence: LAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRS Prediction: ---+-++-+--+--++-+------+-++--+---------------+---+--+---+++ Confidence: 545726665245225525544642646846575929576584754943666255332485 Sequence: NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV Prediction: -----------------+----------------+-++--+---------+--+---+-- Confidence: 247287923247848995879457766768638354583363257528734469288599 Sequence: IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL Prediction: -----------++------+------------------- Confidence: 996786862447432346646333467789869989849 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|O95677|EYA4_HUMAN Eyes absent homolog 4 OS=Homo sapiens GN=EYA4 PE=1 SV=2 Sequence: MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSS Prediction: ----------+-+----------------------------------+---+--+-+--- Confidence: 657648725336413454879866123244797896254589765413212542423441 Sequence: TSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTF Prediction: ------------------------------------------------------------ Confidence: 438654513564856856746998856546667799994651524766583566445537 Sequence: TGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTA Prediction: ---------+--++-+------------------+------------------------- Confidence: 564584514431741422332734524343462231311257476355457654545234 Sequence: YSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQM Prediction: --------------------------------+----------+--------+------- Confidence: 242112321524455886835535432422215543365622232424214251213336 Sequence: PGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTA Prediction: -----------------------------------------------+------------ Confidence: 346266533562876673243344513333443244431214332233114526341357 Sequence: DGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRGRGRKNNP Prediction: -----++----------------------+-+++-------+--+++-+++++++++++- Confidence: 655214513236433343433123342213144516387683227462887958689642 Sequence: SPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTH Prediction: -+---------------------------++--+--+------+---+------------ Confidence: 154431297288957999899997578213321513423235752144854789686653 Sequence: LFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRK Prediction: ------------------+--+--------------+----+-+----+--++++++-++ Confidence: 757389789738395242423322242234653334433214253472324867435375 Sequence: LAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRS Prediction: --+++++-+--+-+++++-----++-++--+-------------------+-------+- Confidence: 224848545114144645512415415812544917688895742833983874764252 Sequence: NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV Prediction: +--+---------------------------+--+--+--+-+---+---+--++--+-- Confidence: 527476814237836782778256654668344244242362426544518147756473 Sequence: IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL Prediction: --------+--+-+++---+---+--------------- Confidence: 623345434446146413243114458658348959858 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>O95677|EYA4 Sequence: MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSS Prediction: ------------------------------------------------------------ Confidence: 000000000000010000000000000000000000000120011001000000000000 Sequence: TSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTF Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: TGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTA Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000001000010000000000000000000000000 Sequence: YSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQM Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: PGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTA Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: DGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRGRGRKNNP Prediction: --------------------------------------------++++++++++++++++ Confidence: 000000000000000000000000000000000100000014445665896888878765 Sequence: SPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTH Prediction: -+-----------------------------------------+---------------- Confidence: 354413111300010000000014301234224101212431272223000000000000 Sequence: LFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRK Prediction: ---------------------------------------------------++--++--- Confidence: 000000000000000000000000000010000000000000000001232854355234 Sequence: LAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRS Prediction: +-+++++-++---+-----------------------------+---------------- Confidence: 547878827612353144011101202200000000002110254241012001000001 Sequence: NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV Prediction: +--+------+--++---------------------+---+-++--++-++--++--+-- Confidence: 521732243483267104000000201020141433633361551386268347724822 Sequence: IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL Prediction: +++++-++---++-+++-++-+--------++-------- Confidence: 6677746532365365646736343402416520101110 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSS Prediction: -------------+----------+++++-----------------++++-+---++--- Confidence: 122323000212333220010011453641203220001000010244343410344232 Sequence: TSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTF Prediction: --+-++------------------------------------------------------ Confidence: 134244232222222211101011212121122110002110000100100000000100 Sequence: TGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTA Prediction: ------------++-----------+-+-------------------------------- Confidence: 000000000312530100021112252300000100000000000101310011000000 Sequence: YSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQM Prediction: ------------------------------------------------------------ Confidence: 000000000100000000010221200001022102201002000001020000101020 Sequence: PGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTA Prediction: ---------------+--+----------------------------------------- Confidence: 211100100000022412313321110010012000000100000000010110101000 Sequence: DGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRGRGRKNNP Prediction: ---------------------------------+--+---++++++++++++++++++++ Confidence: 001000000000001102301000001020130312420346389799999999899877 Sequence: SPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTH Prediction: +++-+------------------------+---++------------------------- Confidence: 784342000000000000000000000134300541101000011021000000000002 Sequence: LFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRK Prediction: ------------------++++-----------------------------++++-+-++ Confidence: 000000000000000011354522211000101222301111211011213586537147 Sequence: LAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRS Prediction: ++++-++-+--+++++++++++----++------------------------------++ Confidence: 555507604215486477976512014520110030000000000000000000000355 Sequence: NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV Prediction: +--+----------------------------------------------+--++--+-- Confidence: 321500000100020000000000000000000020031232220030004227721421 Sequence: IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL Prediction: -+-++--------------+--+---------------- Confidence: 233351121002220131151233000000000000000 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.