| Detail-Interactions: | |
| RAID ID: | RPI00000031 |
|---|---|
| RNA/Protein Symbol 1: | BCYRN1 |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | EIF4A3(eIF4A) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | Electrophoretic Mobility Shift Assay (EMSA), UV Cross-linking Assay |
| Tissue: | HEK293 cells |
| PMID: | 18316401 |
| Detail description: | Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. |
| The Predicated Binding Sites between BCYRN1 and EIF4A3 | |||||
| By miRanda | Structure | Match Score | Energy Score | BCYRN1 Location | EIF4A3 Location |
| The Predicated Binding Sites between BCYRN1 and EIF4A3 | ||||
| By RIsearch | Structure | BCYRN1 Location | EIF4A3 Location | Score |
| The Predicated Binding Sites of EIF4A3 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|P38919|IF4A3_HUMAN Eukaryotic initiation factor 4A-III OS=Homo sapiens GN=EIF4A3 PE=1 SV=4 Sequence: MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK Prediction: ---+-+--++++++++--------+----------------+---+----+----+---+ Confidence: 662546237899598847246572572453477658452766378548686792755554 Sequence: PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV Prediction: -+----+--+------------+++++++-+-------------+----------+---- Confidence: 443532558725828266463279897982733749968978295433986674365647 Sequence: QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA Prediction: ---+-------------------+------+---+-------+--+-----++++-+++- Confidence: 494578777874638385847544263358726447367744424785347668829985 Sequence: IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL Prediction: -+---------------+-----------------------------------+---+-- Confidence: 767999999989832555569369424644733897937297589989542765669655 Sequence: VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA Prediction: ---------------------------------------------++++--------+-- Confidence: 822545266783699879724532785899958384944998552557543262638647 Sequence: NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL Prediction: +---+----+-+++-++------+++-++---------+------------------+-- Confidence: 473652543525653644752467542595673348375786763947996466435446 Sequence: YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI Prediction: +--+-+++++++++-------+----------------------------- Confidence: 585644989996973655368467762992787452332964878799899 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|P38919|IF4A3_HUMAN Eukaryotic initiation factor 4A-III OS=Homo sapiens GN=EIF4A3 PE=1 SV=4 Sequence: MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK Prediction: --+--------------------------------------------------------- Confidence: 343342541112223185689898797887668887732554889567963895867663 Sequence: PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV Prediction: -+--+------------------++++++---------------+--+-----+-+---- Confidence: 345343169476637458663615784885339988977767363433776333155388 Sequence: QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA Prediction: ------------------------+-----+---+-------+--+-------------- Confidence: 595499798964447297853122323367338435847633513486369451383524 Sequence: IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL Prediction: ------------------------------------------------------------ Confidence: 858889447447631356778789624843545487837195678869976666788285 Sequence: VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA Prediction: ---------------------------------------------+-+------------ Confidence: 632543385565898898434623999999976774964977671333586697889268 Sequence: NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL Prediction: ---------++++--+-------------------------------------------- Confidence: 575872512334535387676751444326563213452566552747893657337756 Sequence: YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI Prediction: ---+--++++++++------------------------------------- Confidence: 272532968978762266768546752892898777765778778798598 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>P38919|EIF4A3 Sequence: MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK Prediction: --------------------------------------------------+--+++++-+ Confidence: 010000000000000000000000000000000000000101120202005425585737 Sequence: PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV Prediction: ++++--+---+--+-++---+++++++++-+---------------------+++++--- Confidence: 775544741361161653428567899974542241041001204103122176898102 Sequence: QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA Prediction: ---+---+---+---+-+++++++++++---------+--++++++-++--+++++++++ Confidence: 201510161225132518588889966721310232053459989945734789758786 Sequence: IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL Prediction: -+-----------++------------------------+--+------++--++--+-- Confidence: 271111322331156212210320142021001000034512500110256418843833 Sequence: VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA Prediction: -+---++-+--++----------+------------------+++++++--+---+-+-- Confidence: 163145528425622230130015011114011223224223579899822542460612 Sequence: NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL Prediction: ----+--+++--+----------+++-++----++---+-----------+-+-+-+-+- Confidence: 342263485524610200014227754581123653337213142023115464547454 Sequence: YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI Prediction: --+++++++++++++++++--------------+-------+---+------ Confidence: 4489689999989998558323301130021015423321150216032000 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK Prediction: -++----------+-------------------------------------------+-+ Confidence: 334102122300240220001000000000000000000000000000010000000426 Sequence: PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV Prediction: +++-+-+--------++-----+++++++-----------------++--+--+------ Confidence: 575040500000002660001299995990000000010000100159214005120000 Sequence: QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA Prediction: ---------------+---++++++---+---++++++----+-++------+------+ Confidence: 000000000001011500056555432332323895533201533930210272200037 Sequence: IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL Prediction: ------++----+------------------+----+++---+----------------- Confidence: 002000340312510030000100013222242000455300320010000210100200 Sequence: VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA Prediction: -+++-+--------------------------------+-+-+-+-+++----------- Confidence: 043426222100000020010221010000000000006351526284400000000000 Sequence: NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL Prediction: -----+++-++-+--+-+-----+-++++--++-+-----------------------++ Confidence: 010004793951420603111236239640254050010010010000000000020044 Sequence: YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI Prediction: -+++++++++++++-+-----------------+----------------- Confidence: 049969979969932402020200000000100413200201320200000 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.