| Detail-Interactions: | |
| RAID ID: | RPI00000015 |
|---|---|
| RNA/Protein Symbol 1: | TERC(telomerase RNA) |
| RNA/Protein Category 1: | lncRNA |
| RNA/Protein Symbol 2: | DKC1(DKC) |
| RNA/Protein Category 2: | Protein |
| Validated Method: | |
| Tissue: | |
| PMID: | 10591218 |
| Detail description: | DKC is associated with human telomerase RNA, which contains an H/ACA RNA motif. Telomerase adds simple sequence repeats to chromosome ends using an internal region of its RNA as a template, and is required for the indefinite proliferation of primary human cells. |
| The Predicated Binding Sites between TERC and DKC1 | |||||
| By miRanda | Structure | Match Score | Energy Score | TERC Location | DKC1 Location |
| The Predicated Binding Sites between TERC and DKC1 | ||||
| By RIsearch | Structure | TERC Location | DKC1 Location | Score |
| The Predicated Binding Sites of DKC1 | |
| RBPBD | |
| RsiteDB | |
| BindN |
>sp|O60832|DKC1_HUMAN H/ACA ribonucleoprotein complex subunit 4 OS=Homo sapiens GN=DKC1 PE=1 SV=3 Sequence: MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFD Prediction: ----------+++++++++++--------------------++--+-++----------- Confidence: 898999888379999999985545889969659889984756743954623538893586 Sequence: KLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGH Prediction: +-+-++++-------+++-++------++---+--+++++++-------++--+--++++ Confidence: 646686552235443785367575458746555756578564348797955887636657 Sequence: SGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGAL Prediction: +++-+-+-+--------+--+--++++++-+------+--------++-++--------- Confidence: 756442575579987986728247466853553566959657656255557553382446 Sequence: FQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVG Prediction: --+-------+++-+-+---------+---++-----------++-++------------ Confidence: 744767446648638452636426725325548748694867345775889599899765 Sequence: GQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLV Prediction: ------++-+++--+---------------------+--++-++------------++-- Confidence: 424225675965335326459499999996593554442557768925982742325755 Sequence: MKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDH Prediction: ----------+--+-------+---------------++------------+-------- Confidence: 536378278747759784578567777795699988356636878999982567822685 Sequence: GIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYS Prediction: ----+--+------++-+++--++++++++---------++-+++++++-+++------- Confidence: 577749275874234627542244858667557246663443866567626444538433 Sequence: ESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAK Prediction: ++-++-------+---------+++++++++++++-----------++++++++++++-+ Confidence: 663755888798596387756389899998885653223455224477899999999928 Sequence: AGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE Prediction: ----+---+++-+++++++++++++-+------- Confidence: 2253535355626778999999998263758957 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| BindN+ |
>sp|O60832|DKC1_HUMAN H/ACA ribonucleoprotein complex subunit 4 OS=Homo sapiens GN=DKC1 PE=1 SV=3 Sequence: MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFD Prediction: ----------++++++++++---------------------------------------- Confidence: 365967756169989988762648999899879888684642277285244669892378 Sequence: KLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGH Prediction: ----+---------+++++++-+-----+------+--+-+++------++--+--++++ Confidence: 242753524267454557368135123236443745224374747233966444717456 Sequence: SGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGAL Prediction: +++-+------------+-++--+------------------------------------ Confidence: 346541183457677767647545652778483898939579797958998999796675 Sequence: FQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVG Prediction: ------+++++++++--+-+-----------------------++-++------------ Confidence: 614534546588446113757356733616447879796742637654464597887553 Sequence: GQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLV Prediction: ------++-++------------------------------------------------- Confidence: 325225454562664966799798999998897789699679879978997988644256 Sequence: MKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDH Prediction: ----------+--+---------------------------------------------- Confidence: 767689887261145565688589799898899898764766665676775687885775 Sequence: GIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYS Prediction: -------+-------+++++++++++++++---------++-+++---+----------- Confidence: 553515262256333687575567886657341446432661746221343243755557 Sequence: ESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAK Prediction: ---------------------------------------------------++++++++- Confidence: 568578999999798899988733533559768768645568536855431446646432 Sequence: AGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE Prediction: ----------------+++++++++--------- Confidence: 4687689877783433478898684536769726 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| RNAbindR |
>O60832|DKC1 Sequence: MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFD Prediction: -----------+-------+---------------------------------------- Confidence: 111010111315344432352000110000000000002000000200032111200000 Sequence: KLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGH Prediction: -------------+---------------------+++++++++-----+-----+++++ Confidence: 000000000010154122122201110021004146778875871243053012056787 Sequence: SGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGAL Prediction: -++-+++-+++-++---+-++-----+---+----------------------------- Confidence: 399369816671663148365003006124711100030200001101003003400433 Sequence: FQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVG Prediction: ++++++++++++++++++++--+--------+----+-+-++++--++---------++- Confidence: 687898999899879689664262343424262144717355874188111402111554 Sequence: GQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLV Prediction: -+-+-+++-+++-----------------------------------+-----+---+-- Confidence: 272745883765113201200200100000001010110110421135023005314812 Sequence: MKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDH Prediction: -++++-++++++++---+-------------------+-+-------------------- Confidence: 256652675575574318421200000001002101362643120123012121012134 Sequence: GIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYS Prediction: +-----++---++++++++++++++++++++-+--+---+----+--+------------ Confidence: 711120683447998999999999998888646426413543437316411300110000 Sequence: ESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAK Prediction: ------------------------------------------------------------ Confidence: 010000000000000000000000100000000000000000000000121233321211 Sequence: AGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE Prediction: ------------------+-+--++---------- Confidence: 01000101111011121454532651110000130 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
| Pprint |
Sequence: MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFD Prediction: --------+++++++++++----------------------------------------- Confidence: 111010333558888745633131001000000000002001020200000000000000 Sequence: KLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGH Prediction: ---------------+++-+++-------------+-+-+++++-++--++--+-+++++ Confidence: 000010010000022565265510100300000004340457650550075036299999 Sequence: SGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGAL Prediction: ++++++-----------+-+++++-+++--+-------------+-+------------- Confidence: 999776202000102016066467055812610000010100224340000000000000 Sequence: FQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVG Prediction: -+-++++++++++-++--++------------------+++++++-+-----------++ Confidence: 143475999599506403340000000000000000216489999092000000000185 Sequence: GQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLV Prediction: ++-++-++-++-+++--------------------------------------------- Confidence: 643540393663764100000000000000000100000000000000000000000000 Sequence: MKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDH Prediction: ----------+------------------------------------------------- Confidence: 000101033332200000000300002012000100100000000000002031212222 Sequence: GIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYS Prediction: ++-----+---++---++-++-+++++-++-++------++++++++++----------- Confidence: 432022351204503343345148644345134012302474634456600110000000 Sequence: ESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAK Prediction: ---------------------------+----------------------++++++++++ Confidence: 000010000000000000000011022332010000000000100000034455897797 Sequence: AGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE Prediction: -++-+-------+-++++++++++++++------ Confidence: 3543420001223353466867676534020110 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.