Detail-Interactions: | |
RAID ID: | RPI00000008 |
---|---|
RNA/Protein Symbol 1: | CDKN2B-AS1(ANRIL) |
RNA/Protein Category 1: | lncRNA |
RNA/Protein Symbol 2: | CBX7 |
RNA/Protein Category 2: | Protein |
Validated Method: | CLip, RNA Electrophoretic Mobility Shift Assay (EMSA) (RNA EMSA) |
Tissue: | PC3 cells, HeLa S3 cells |
PMID: | 20541999 |
Detail description: | Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues. |
The Predicated Binding Sites between CDKN2B-AS1 and CBX7 | |||||
By miRanda | Structure | Match Score | Energy Score | CDKN2B-AS1 Location | CBX7 Location |
The Predicated Binding Sites between CDKN2B-AS1 and CBX7 | ||||
By RIsearch | Structure | CDKN2B-AS1 Location | CBX7 Location | Score |
The Predicated Binding Sites of CBX7 | |
RBPBD | |
RsiteDB | |
BindN |
>sp|O95931|CBX7_HUMAN Chromobox protein homolog 7 OS=Homo sapiens GN=CBX7 PE=1 SV=1 Sequence: MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK Prediction: --------------+-++++-++++--+------++-+++-------------------+ Confidence: 979588877988836497892995772469252455276422667999989499573646 Sequence: EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA Prediction: --+-++++++++++++++-------+-+-+++++++-+-+----------+-+-----+- Confidence: 237386878999999578456329253558788989263565649353438263235766 Sequence: GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP Prediction: -------------------+++++++++-+-++++++++-++-++++-++---------- Confidence: 474478648457428432378599588648368795678358268862763758688685 Sequence: DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA Prediction: ------------------------------------+-----------+-+---+----- Confidence: 798386777646724445676977636234222464522737358363556528568477 Sequence: EGFFRDRSGKF Prediction: ----+-++-+- Confidence: 35475574373 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
BindN+ |
>sp|O95931|CBX7_HUMAN Chromobox protein homolog 7 OS=Homo sapiens GN=CBX7 PE=1 SV=1 Sequence: MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK Prediction: -------------------+-++++--+-------------------------------- Confidence: 667679999979973624292663556336132336534523778889889798595631 Sequence: EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA Prediction: ----+-++++++++++-+-+-++-+-------+-----------------+--------- Confidence: 322541434858457517143343355582424222623347777674524113327714 Sequence: GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP Prediction: -----------------------------+----+--++--+--++-++----------- Confidence: 277687567545364575512414835594511152245323423713611225463756 Sequence: DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA Prediction: --------------------------------------------------+-+-+----- Confidence: 878386474657777799899877512222346698636868866262245346744378 Sequence: EGFFRDRSGKF Prediction: ------++-+- Confidence: 35341365451 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
RNAbindR |
>O95931|CBX7 Sequence: MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK Prediction: --------------+--++++++++-+++-+++++------------------------- Confidence: 100100001020047238899999938863887662321321000010000000000001 Sequence: EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA Prediction: ----+-+++++++++++++-++++----------------------------------+- Confidence: 321162688999998778645555422213211123310230011011012232222253 Sequence: GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP Prediction: --------------------------------------+------+---+---------- Confidence: 111100101211311221131121000103143441126004223643453132120210 Sequence: DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA Prediction: -----------------------------------------------++-+++-++-+-- Confidence: 001001000000000000000000010023223111011110341227537563862533 Sequence: EGFFRDRSGKF Prediction: +++++-+--+-- Confidence: 658664744710 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
Pprint |
Sequence: MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK Prediction: ----------------+-++++++++++--+-+-+--++++------------------+ Confidence: 021020000000002232695777953430426060154540010100000000000004 Sequence: EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA Prediction: ----++++++++++++++---+--+----+++++++++++-+----------+-+----- Confidence: 000255889989857745020320311137558643554434120101003342311010 Sequence: GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP Prediction: ---------------+++-+++++++++++-++++--+++++---+--+----------- Confidence: 000000000000100333165465578548335542255444122310410000001000 Sequence: DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA Prediction: ------------------------------------------------------------ Confidence: 100000000000000000000000000100000000000000010000002110100100 Sequence: EGFFRDRSGKF Prediction: -++------+- Confidence: 14501223243 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.