The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RPI00000005
RNA/Protein Symbol 1:BACE1-AS
RNA/Protein Category 1: lncRNA
RNA/Protein Symbol 2: APP
RNA/Protein Category 2: Protein
Validated Method: Enzyme-linked immunosorbent assay (ELISA), HTRF Assay, Ribonuclease Protection Assay (RPA)
Tissue: brain 
PMID: 18587408 
Detail description:

BACE1-AS is directly implicated in the increased abundance of A|? 1¡§C42 in Alzheimer?¡¥s disease. 

The Predicated Binding Sites between BACE1-AS and APP
By miRanda Structure Match Score Energy Score BACE1-AS Location APP Location
The Predicated Binding Sites between BACE1-AS and APP
By RIsearch Structure BACE1-AS Location APP Location Score
The Predicated Binding Sites of APP
RBPBD
RsiteDB
BindN
>sp|P05067|A4_HUMAN Amyloid beta A4 protein OS=Homo sapiens GN=APP PE=1 SV=3

Sequence:    MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Prediction:  ---------------+-----+-----------------+-------++-+-++++++++
Confidence:  897999999988437775273554276678786996776784646485527245447578

Sequence:    TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Prediction:  +----------------------------------++-+++++++++-------------
Confidence:  625533555866947938695945995842572824527969996853546899738897

Sequence:    EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Prediction:  ----------------------------------+-+-++++++---------------+
Confidence:  799389988673724525738577444966557752626465545355988957676285

Sequence:    GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Prediction:  ------------------------------------+-----------------------
Confidence:  896898889866452722526247736944457323442434739959989989969677

Sequence:    EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Prediction:  -------------------------+-+++++++++++++-------+-------++-+-
Confidence:  786786788787796799576454344656754778775534846994797222557354

Sequence:    RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
Prediction:  +----+--------+---------++++++------------+---++--+++-++--+-
Confidence:  943645657785375663783742658976233784987984634255357443555666

Sequence:    PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Prediction:  --+--+++-++---------++----------+-+-+-+-+++-+-++--+------+--
Confidence:  456637654642336734644535334462527453735276727345765765463524

Sequence:    KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Prediction:  ++-++--++------------------------------+-------+++----------
Confidence:  864684275776358674952743444352336844355894624445565465759389

Sequence:    QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Prediction:  -----+-+----------+-++++++---------------+-++-++------+-----
Confidence:  453236473844782226827786862253676692674526357685275369487372

Sequence:    MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Prediction:  -----------------------------+-+------------+------------+--
Confidence:  632463884697889589699998985335253668887892665722736675725522

Sequence:    KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Prediction:  +--------------------------+-+-+----------+----++-++++++--++
Confidence:  622755758466848878476435563536252445864837625438527795582277

Sequence:    IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Prediction:  -+------------------+---------------+-+---------------------
Confidence:  563557349365656246354363683998998764636356879897789783999958

Sequence:    VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Prediction:  ---+++++++------------+---++-++-+++-+++--+--------
Confidence:  96766676648438997967766344645573566365522437766965


*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).


BindN+
>sp|P05067|A4_HUMAN Amyloid beta A4 protein OS=Homo sapiens GN=APP PE=1 SV=3

Sequence:    MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Prediction:  ---------------------------------------+----------++----++++
Confidence:  567588989768559278583473156736775775652641423292124432245446

Sequence:    TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Prediction:  +---------------+------+------------+-++++++++++------------
Confidence:  514224765744814634361843782533761621427846975765312334414475

Sequence:    EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Prediction:  -------------+-----+-----+--------+-----+----+-------------+
Confidence:  466288879524631321245266341521226335546443235333463725264136

Sequence:    GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Prediction:  ------------------------------------------------------------
Confidence:  366375866888876745889899847854779989799988989999999999999999

Sequence:    EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Prediction:  ----------------------------------------------------------+-
Confidence:  899999899868878999999999999799999999999997855682672563653152

Sequence:    RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
Prediction:  +-----+------+---------+++++++------------------------------
Confidence:  821532331122132744482314668375442567897663223424973336657546

Sequence:    PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Prediction:  -----------------+-------------++-+-+---+++-+-++--+-+-------
Confidence:  562878748442444554865757423131345244433265717144226634575213

Sequence:    KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Prediction:  ++-++------------------------+---------+-------+++----------
Confidence:  536672421864515353874666442164247854187594514124678588779679

Sequence:    QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Prediction:  -----+-++--+----+-+++-++++++-+---+-+----++-+--+-------+----+
Confidence:  574218146625461236833153744534223475352336241734355237367355

Sequence:    MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Prediction:  ------------------------------------------------------------
Confidence:  512231786597678699379978887552546879897886752832779998977675

Sequence:    KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Prediction:  ------------------------------------------++----------------
Confidence:  566887778468759777443135376752546738973515553441344525534744

Sequence:    IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Prediction:  ------------------+-------+----------++---------------------
Confidence:  956987477537733215432133454787999762246233637433433353676645

Sequence:    VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Prediction:  ---+++++++-++---------+---++-++-+++-+++-+++-------
Confidence:  32465767563343542734354412653672464164514655532722


*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).

RNAbindR
>P05067|APP
Sequence:    MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Prediction:  --------------------------------+------+-+------------------
Confidence:  000000000000000000000201412231335232331515110202100100001211

Sequence:    TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Prediction:  -+---------++-------+--+--------+-++++++++++++++++++++++----
Confidence:  360321021235743222026126112123115368666968889989897677563201

Sequence:    EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Prediction:  -------------+--+---------+--+----------++++-+----------+---
Confidence:  220121131434450151342010135245311232343485661832341043136303

Sequence:    GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Prediction:  ------------------------------------------------------------
Confidence:  102000100100000000000000000000000000000000000000000000000000

Sequence:    EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Prediction:  ------------------------------------------------------------
Confidence:  000010000000000000000000000100000000000000000000000000000111

Sequence:    RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
Prediction:  -----+-----------++-++++++++++------------------------------
Confidence:  221018332102333138637787899899433100100000000000001000030112

Sequence:    PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Prediction:  -----------------------------------------+------------------
Confidence:  000011122201001000001001000011000000211145102213111121002120

Sequence:    KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Prediction:  +---+--+-+---+---------------------------------+++----------
Confidence:  732253473631261222111010101022220102321100011325851122111200

Sequence:    QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Prediction:  -----+-+++-++-++--+---+++++++++-++--------------------------
Confidence:  101348478549536742611256678569947823331130200010000010000111

Sequence:    MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Prediction:  ------------------------------------------------------------
Confidence:  031212101100000000000000000000000000000000000000000000000000

Sequence:    KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Prediction:  ------------------------------------------------------------
Confidence:  000000000000000000000000000000000000000000000000000000000000

Sequence:    IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Prediction:  -----------------------------------+---+--------------------
Confidence:  000000000000000020011101000000100016133612232111112011001111

Sequence:    VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Prediction:  ---++++++++++++++-----+---+------++++++++++--------
Confidence:  144889889978976552342263325403423676978877810110120

*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).
                 
Pprint
Sequence:    MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
Prediction:  ---------------------------------------+-+++-----+++--++-+++
Confidence:  001100000000101100000000000000000000102423343203234512541844

Sequence:    TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
Prediction:  +++----------------+---------+--++++++++++++++++++++++-+----
Confidence:  564120000000130230032001000003035678999999999997535464330330

Sequence:    EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Prediction:  ---------------------++-+-+++++++++-------------------------
Confidence:  000000000001021011232451435764343351120002000210000021000102

Sequence:    GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Prediction:  ---+--------------------------------------------------------
Confidence:  002401010200131121000000000000000000000000000000000000000000

Sequence:    EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
Prediction:  ---------------------------------------------------------++-
Confidence:  000000000000000000000100000211100000000000000003000001000582

Sequence:    RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
Prediction:  +----+-++++--+---+--++++++++++++++-+-++++--++++-++++--------
Confidence:  721007257432032003339899999999455503265592266443443421021000

Sequence:    PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
Prediction:  ---------------------------+----+-++++--++++++-++++-------+-
Confidence:  000000201000000200000000003411003243752278558507457130000040

Sequence:    KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
Prediction:  ---++----------------+--+--------------+---+----+-----------
Confidence:  232642002000130200001311501023220000000401140031410000010000

Sequence:    QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
Prediction:  ---++++++-++--++--+---++-++--++-------++------+-+-----+-----
Confidence:  002556579345114310301274253203823201136632110061421320410221

Sequence:    MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
Prediction:  ------------------------------------------------------------
Confidence:  312020220200000000000000000002001011100111112111000000000000

Sequence:    KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
Prediction:  ------------------------------------------+-----------------
Confidence:  000000000000000110201212010011020000000011523213221121122221

Sequence:    IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
Prediction:  ----------------+++++-------------+---++---+-----+----------
Confidence:  000000000000001344475212000000010333024422130011240002210200

Sequence:    VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Prediction:  ---++++++++++----------+--++--+---+---+---+-------
Confidence:  00064633476561110000000412540350234220311040012011

***Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
***Confidence:  from level 0 (lowest) to level 9 (highest).
                 
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.