Detail-Interactions: | |
RAID ID: | RPI00000005 |
---|---|
RNA/Protein Symbol 1: | BACE1-AS |
RNA/Protein Category 1: | lncRNA |
RNA/Protein Symbol 2: | APP |
RNA/Protein Category 2: | Protein |
Validated Method: | Enzyme-linked immunosorbent assay (ELISA), HTRF Assay, Ribonuclease Protection Assay (RPA) |
Tissue: | brain |
PMID: | 18587408 |
Detail description: | BACE1-AS is directly implicated in the increased abundance of A|? 1¡§C42 in Alzheimer?¡¥s disease. |
The Predicated Binding Sites between BACE1-AS and APP | |||||
By miRanda | Structure | Match Score | Energy Score | BACE1-AS Location | APP Location |
The Predicated Binding Sites between BACE1-AS and APP | ||||
By RIsearch | Structure | BACE1-AS Location | APP Location | Score |
The Predicated Binding Sites of APP | |
RBPBD | |
RsiteDB | |
BindN |
>sp|P05067|A4_HUMAN Amyloid beta A4 protein OS=Homo sapiens GN=APP PE=1 SV=3 Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK Prediction: ---------------+-----+-----------------+-------++-+-++++++++ Confidence: 897999999988437775273554276678786996776784646485527245447578 Sequence: TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG Prediction: +----------------------------------++-+++++++++------------- Confidence: 625533555866947938695945995842572824527969996853546899738897 Sequence: EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR Prediction: ----------------------------------+-+-++++++---------------+ Confidence: 799389988673724525738577444966557752626465545355988957676285 Sequence: GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE Prediction: ------------------------------------+----------------------- Confidence: 896898889866452722526247736944457323442434739959989989969677 Sequence: EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC Prediction: -------------------------+-+++++++++++++-------+-------++-+- Confidence: 786786788787796799576454344656754778775534846994797222557354 Sequence: RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD Prediction: +----+--------+---------++++++------------+---++--+++-++--+- Confidence: 943645657785375663783742658976233784987984634255357443555666 Sequence: PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA Prediction: --+--+++-++---------++----------+-+-+-+-+++-+-++--+------+-- Confidence: 456637654642336734644535334462527453735276727345765765463524 Sequence: KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL Prediction: ++-++--++------------------------------+-------+++---------- Confidence: 864684275776358674952743444352336844355894624445565465759389 Sequence: QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER Prediction: -----+-+----------+-++++++---------------+-++-++------+----- Confidence: 453236473844782226827786862253676692674526357685275369487372 Sequence: MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET Prediction: -----------------------------+-+------------+------------+-- Confidence: 632463884697889589699998985335253668887892665722736675725522 Sequence: KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN Prediction: +--------------------------+-+-+----------+----++-++++++--++ Confidence: 622755758466848878476435563536252445864837625438527795582277 Sequence: IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL Prediction: -+------------------+---------------+-+--------------------- Confidence: 563557349365656246354363683998998764636356879897789783999958 Sequence: VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN Prediction: ---+++++++------------+---++-++-+++-+++--+-------- Confidence: 96766676648438997967766344645573566365522437766965 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
BindN+ |
>sp|P05067|A4_HUMAN Amyloid beta A4 protein OS=Homo sapiens GN=APP PE=1 SV=3 Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK Prediction: ---------------------------------------+----------++----++++ Confidence: 567588989768559278583473156736775775652641423292124432245446 Sequence: TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG Prediction: +---------------+------+------------+-++++++++++------------ Confidence: 514224765744814634361843782533761621427846975765312334414475 Sequence: EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR Prediction: -------------+-----+-----+--------+-----+----+-------------+ Confidence: 466288879524631321245266341521226335546443235333463725264136 Sequence: GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE Prediction: ------------------------------------------------------------ Confidence: 366375866888876745889899847854779989799988989999999999999999 Sequence: EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC Prediction: ----------------------------------------------------------+- Confidence: 899999899868878999999999999799999999999997855682672563653152 Sequence: RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD Prediction: +-----+------+---------+++++++------------------------------ Confidence: 821532331122132744482314668375442567897663223424973336657546 Sequence: PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA Prediction: -----------------+-------------++-+-+---+++-+-++--+-+------- Confidence: 562878748442444554865757423131345244433265717144226634575213 Sequence: KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL Prediction: ++-++------------------------+---------+-------+++---------- Confidence: 536672421864515353874666442164247854187594514124678588779679 Sequence: QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER Prediction: -----+-++--+----+-+++-++++++-+---+-+----++-+--+-------+----+ Confidence: 574218146625461236833153744534223475352336241734355237367355 Sequence: MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET Prediction: ------------------------------------------------------------ Confidence: 512231786597678699379978887552546879897886752832779998977675 Sequence: KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN Prediction: ------------------------------------------++---------------- Confidence: 566887778468759777443135376752546738973515553441344525534744 Sequence: IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL Prediction: ------------------+-------+----------++--------------------- Confidence: 956987477537733215432133454787999762246233637433433353676645 Sequence: VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN Prediction: ---+++++++-++---------+---++-++-+++-+++-+++------- Confidence: 32465767563343542734354412653672464164514655532722 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
RNAbindR |
>P05067|APP Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK Prediction: --------------------------------+------+-+------------------ Confidence: 000000000000000000000201412231335232331515110202100100001211 Sequence: TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG Prediction: -+---------++-------+--+--------+-++++++++++++++++++++++---- Confidence: 360321021235743222026126112123115368666968889989897677563201 Sequence: EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR Prediction: -------------+--+---------+--+----------++++-+----------+--- Confidence: 220121131434450151342010135245311232343485661832341043136303 Sequence: GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE Prediction: ------------------------------------------------------------ Confidence: 102000100100000000000000000000000000000000000000000000000000 Sequence: EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC Prediction: ------------------------------------------------------------ Confidence: 000010000000000000000000000100000000000000000000000000000111 Sequence: RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD Prediction: -----+-----------++-++++++++++------------------------------ Confidence: 221018332102333138637787899899433100100000000000001000030112 Sequence: PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA Prediction: -----------------------------------------+------------------ Confidence: 000011122201001000001001000011000000211145102213111121002120 Sequence: KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL Prediction: +---+--+-+---+---------------------------------+++---------- Confidence: 732253473631261222111010101022220102321100011325851122111200 Sequence: QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER Prediction: -----+-+++-++-++--+---+++++++++-++-------------------------- Confidence: 101348478549536742611256678569947823331130200010000010000111 Sequence: MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET Prediction: ------------------------------------------------------------ Confidence: 031212101100000000000000000000000000000000000000000000000000 Sequence: KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN Prediction: ------------------------------------------------------------ Confidence: 000000000000000000000000000000000000000000000000000000000000 Sequence: IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL Prediction: -----------------------------------+---+-------------------- Confidence: 000000000000000020011101000000100016133612232111112011001111 Sequence: VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN Prediction: ---++++++++++++++-----+---+------++++++++++-------- Confidence: 144889889978976552342263325403423676978877810110120 *** Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. *** Confidence: from level 0 (lowest) to level 9 (highest). |
Pprint |
Sequence: MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK Prediction: ---------------------------------------+-+++-----+++--++-+++ Confidence: 001100000000101100000000000000000000102423343203234512541844 Sequence: TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG Prediction: +++----------------+---------+--++++++++++++++++++++++-+---- Confidence: 564120000000130230032001000003035678999999999997535464330330 Sequence: EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR Prediction: ---------------------++-+-+++++++++------------------------- Confidence: 000000000001021011232451435764343351120002000210000021000102 Sequence: GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE Prediction: ---+-------------------------------------------------------- Confidence: 002401010200131121000000000000000000000000000000000000000000 Sequence: EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC Prediction: ---------------------------------------------------------++- Confidence: 000000000000000000000100000211100000000000000003000001000582 Sequence: RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD Prediction: +----+-++++--+---+--++++++++++++++-+-++++--++++-++++-------- Confidence: 721007257432032003339899999999455503265592266443443421021000 Sequence: PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA Prediction: ---------------------------+----+-++++--++++++-++++-------+- Confidence: 000000201000000200000000003411003243752278558507457130000040 Sequence: KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL Prediction: ---++----------------+--+--------------+---+----+----------- Confidence: 232642002000130200001311501023220000000401140031410000010000 Sequence: QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER Prediction: ---++++++-++--++--+---++-++--++-------++------+-+-----+----- Confidence: 002556579345114310301274253203823201136632110061421320410221 Sequence: MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET Prediction: ------------------------------------------------------------ Confidence: 312020220200000000000000000002001011100111112111000000000000 Sequence: KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN Prediction: ------------------------------------------+----------------- Confidence: 000000000000000110201212010011020000000011523213221121122221 Sequence: IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL Prediction: ----------------+++++-------------+---++---+-----+---------- Confidence: 000000000000001344475212000000010333024422130011240002210200 Sequence: VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN Prediction: ---++++++++++----------+--++--+---+---+---+------- Confidence: 00064633476561110000000412540350234220311040012011 ***Prediction: binding residues are labeled with '+' and in red; non-binding residues labeled with '-' and in green. ***Confidence: from level 0 (lowest) to level 9 (highest). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.