The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail-Interactions:
RAID ID: RPI00000001
RNA/Protein Symbol 1:MALAT1
RNA/Protein Category 1: lncRNA
RNA/Protein Symbol 2: AGO2(Ago2)
RNA/Protein Category 2: Protein
Validated Method:
Tissue:  
PMID: 23529762 
Detail description:

In contrast,human MALAT1 interacts with Ago2 in Hela cells suggesting that MALAT1 could be subject to micRNA-mediated regulation. 

The Predicated Binding Sites between MALAT1 and AGO2
By miRanda Structure Match Score Energy Score MALAT1 Location AGO2 Location
The Predicated Binding Sites between MALAT1 and AGO2
By RIsearch Structure MALAT1 Location AGO2 Location Score
The Predicated Binding Sites of AGO2
RBPBD
RsiteDB
BindN
>sp|Q9UKV8|AGO2_HUMAN Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3

Sequence:    MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
Prediction:  -----------------------++--+-+--++-++-+---------------------
Confidence:  722455254523522326242648522825117619837427488797962848365686

Sequence:    IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
Prediction:  ----+-+++--+------------------------++--+--------+----------
Confidence:  814281698428599799956823363462253125752362776526474274869373

Sequence:    GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
Prediction:  ---+-+--+------------------+-+--+-------------------+-+---+-
Confidence:  322546456939359369484985764538527536549699699925641672614582

Sequence:    FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
Prediction:  ---------------+----------+---------------------------------
Confidence:  351512531222235768388874277128419994978251552184699999999979

Sequence:    KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
Prediction:  ----------++--+-+-----+--+-------+-+++++--+--+++-+----------
Confidence:  334343222366118264224664767483252618965722751785271224551341

Sequence:    GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
Prediction:  --+---------+------------------+--+---------------+--++----+
Confidence:  425734366223552524581464756836354172219688995876726247541315

Sequence:    TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
Prediction:  -++--+-+-++++-+--------++-+-+---------------------+--------+
Confidence:  175259364986627243622638615351342817979793887348366652743647

Sequence:    GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
Prediction:  --+-+------------+-++---------------------------------++--+-
Confidence:  228282432584663676465412496839699975743136217372331215674184

Sequence:    AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
Prediction:  -------------------------------+------------++--+----+------
Confidence:  644372644547238246428447824713256575999998556526743826754486

Sequence:    GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
Prediction:  ----------+-++++++-----------+------------+-----------------
Confidence:  578225726154687757152187819475554844877425833565799979887812

Sequence:    PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
Prediction:  ---++-++-+----------+--++--+-+-+--+-------------------++++++
Confidence:  532561882656478514326237523758471353888699998928999694755958

Sequence:    PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
Prediction:  --+--------------------------------+-------------++-++---+-+
Confidence:  227577426661152844998999999367681845623457368783166167633625

Sequence:    NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
Prediction:  --+--++-+-+--++--++-----------------+-+++++-----------------
Confidence:  428229526163476426653365698979954833618797622398697516226763

Sequence:    ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
Prediction:  -----------+-++--+-------------+-+--------------+++++++++--+
Confidence:  884447734186358155423362295786666623675463524221688798958336

Sequence:    ALAKAVQVHQDTLRTMYFA
Prediction:  -------------+-----
Confidence:  6571762732526637378


*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).

BindN+
>sp|Q9UKV8|AGO2_HUMAN Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3

Sequence:    MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
Prediction:  -+----------------+-+--+++++++++++++----+---------+---------
Confidence:  441444543556733312615225465787788457151353225353823514444241

Sequence:    IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
Prediction:  --+++-++++++------------------------++--+-------------------
Confidence:  314461799579236468948858355453433124371841378747636578999595

Sequence:    GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
Prediction:  ------------+---------------------------------+-----+--+--++
Confidence:  352141561737535439764488898652645668775287276851422444243354

Sequence:    FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
Prediction:  ---------------+------+++-+----+---+---+-+---+--------------
Confidence:  242336346362231333234534476224238444825415242456569779999989

Sequence:    KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
Prediction:  --------------+-+--+-----+---+++++++++++--+--+-------------+
Confidence:  352345435623653647345812747263344668757733551413423523784733

Sequence:    GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
Prediction:  ----------+-+-+++---+-------+--+--++-+------------+--+------
Confidence:  453756446334446534454263446643264285264577987888613354133633

Sequence:    TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
Prediction:  -----+---++-+-+--------+--------------------------+---------
Confidence:  522674524541326455872445211335434725738142277468484422353832

Sequence:    GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
Prediction:  --+-------+++-++-+-++++-+------------------------------+--+-
Confidence:  464222264235317635136451452522376868754337347596679358236333

Sequence:    AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
Prediction:  ---+--------------------------------------------+++-++------
Confidence:  213323556579427349658728835622213487899988642144845635687787

Sequence:    GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
Prediction:  ----+----++-++++-++--+---+---+-++-++----------------------++
Confidence:  778353516444354424556567567246354244756444144325785848293476

Sequence:    PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
Prediction:  +-+-+-++++--+---+---+--------+-++++-------------------++++++
Confidence:  514242543612436154344511245266485535568899569939877842536745

Sequence:    PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
Prediction:  --+----+---++++---------------------------------++++++------
Confidence:  326244354225545352496986799358776873453426645261888668313222

Sequence:    NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
Prediction:  -----+--+-+------+--------------+----++++++++-------+-------
Confidence:  131234115231321533352144468968545342268595654257556436522782

Sequence:    ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
Prediction:  ---------+-+--+--+---+-+--+----+-+-------------++++++++-+--+
Confidence:  597436415475615235322345284435346544897896646633557544426313

Sequence:    ALAKAVQVHQDTLRTMYFA
Prediction:  -------------+-----
Confidence:  6432682635364523337


*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).

RNAbindR
>Q9UKV8|AGO2
Sequence:    MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
Prediction:  --+-+------------------+-+++++++++++++++++++------------+---
Confidence:  036151211000000110212106478999999899859886954323001020245424

Sequence:    IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
Prediction:  -++++++++++++-----------------+-+++++++-++------------------
Confidence:  477596999769620210021001120334645885999487332210341100000000

Sequence:    GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
Prediction:  --+++++-++--+----------------------+---+----+-++---+---+++++
Confidence:  436759645543842442424200100000002015312811345277322642367898

Sequence:    FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
Prediction:  +++++--+------++---++++++-++++-+--+--++--+------+-----------
Confidence:  876752372331246531378578838865482354275215221414611210000000

Sequence:    KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
Prediction:  -------+--+++++++-+++-++-++++++++++++++++++-++++-++---------
Confidence:  000011263275777650675188497869999999989855745896385222102000

Sequence:    GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
Prediction:  ---------+++-++++++-++++++++++++++++-+++-+--+--++++++++-++++
Confidence:  110222342657467885638888875685765778365626245115697778736776

Sequence:    TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
Prediction:  ----+-++-++++++-------------+------+---+----------+++-+++-++
Confidence:  343354564788867223202102303351322046231611100021218664786356

Sequence:    GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
Prediction:  +-+-----++++++++++++++++-+++++++--+----+---------------+--+-
Confidence:  645221206589899999999666455678651253213621114103311331174154

Sequence:    AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
Prediction:  ------+------+--+-++----------------------+++++-+++-++------
Confidence:  441424543111351454550120012021013101100142758994775168024121

Sequence:    GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
Prediction:  ++++++-+-++-++-++++--++-++-+-++++++++----+--------------+-++
Confidence:  755998454992694858844954784648586787521345331113010000236279

Sequence:    PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
Prediction:  +++-+-+-++-+---++++++-++++++-+-++++++----------------+++++++
Confidence:  578364637615444696668178775647398796511130011032001348677898

Sequence:    PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
Prediction:  +++--++++++++++---------------------+-+++--+--++++++++-++---
Confidence:  569435798888756112000100122433111112548653452458999999476344

Sequence:    NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
Prediction:  +----+++++++++---+---+-+----+--+++++++++++++++---+-++-------
Confidence:  742438779777972437432837423364455677788899685822352551123002

Sequence:    ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
Prediction:  ---+---+---+-+++++--++++-++----+----------------------------
Confidence:  000541261248368567145856357442451201000000000000000000000000

Sequence:    ALAKAVQVHQDTLRTMYFA
Prediction:  -------------+++++--
Confidence:  00110121143148778940

*** Prediction:  binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence:  from level 0 (lowest) to level 9 (highest).
                 
Pprint
Sequence:    MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
Prediction:  -----------------------++++++++++--++-+---------------------
Confidence:  223310000000000000001014559996954134405020110000000000000100

Sequence:    IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
Prediction:  ---+++++++++-------------------++-+-++-----------------+-+++
Confidence:  112597999656300000000000120001044243750000000000003111031756

Sequence:    GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
Prediction:  +++++++-+-+-+++-++-----------------+-------------------+--++
Confidence:  778967326072554364000000200023111004110000000000020010050264

Sequence:    FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
Prediction:  +--+++++--++-++++----+-++-+++--+-+++---+--------------------
Confidence:  500444762254345442301335633443253664223402110000000000000000

Sequence:    KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
Prediction:  -------++-++----+-++--++++-+++++++-++-++++++-++---+-----+---
Confidence:  120001264144022352483166472939554426525934672462124220103000

Sequence:    GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
Prediction:  ---------------------++++-----++-++--+-+-+----++-+++++++-++-
Confidence:  201220200000000000101596410230350552233424220036299956843483

Sequence:    TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
Prediction:  -++-+++-++++++------+--+----------------------------------+-
Confidence:  354246533996643122024004101200020010000000000000000000000040

Sequence:    GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
Prediction:  -++--+--++-++++--+++++--+------------++++-----------------+-
Confidence:  045124304424856315447422403010002003345551000100110000000031

Sequence:    AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
Prediction:  -+-----------------+------------------------+++---+--+------
Confidence:  140000030000100212243100010022210001000000224662103035001022

Sequence:    GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
Prediction:  ---------+------++---+--+---++++++++++--+---+-------------++
Confidence:  102321002433120234301300330335748984662242333000000000003278

Sequence:    PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
Prediction:  ++--------------+------+-++-++++++-------------------+-+-+++
Confidence:  661310310032010242222123353368678530120000000000001217352535

Sequence:    PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
Prediction:  ++++-+-+--++++++-+---------+------------+------++++++++--+-+
Confidence:  559324160386867323010000000420100010100230030017987847423635

Sequence:    NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
Prediction:  +++-++++++++++-------------------------+++++++------++------
Confidence:  875268658455540000000010000000003100023465494602130054101201

Sequence:    ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
Prediction:  -------+--++-++--+------------++-+--------------++++++++++++
Confidence:  100100043365155323000000002003642520002212200113446676867657

Sequence:    ALAKAVQVHQDTLRTMYFA
Prediction:  +------------------
Confidence:  4203003001210301311

*** Prediction: binding residues are labeled with '+' and in red;
                 non-binding residues labeled with '-' and in green.
*** Confidence: from level 0 (lowest) to level 9 (highest).
                 
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting RNA/Protein with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting RNA/Protein with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.