ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-34b

MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000403	MIPF0000039	AGUCUAGUUACUAGGCAGUGUAGUUAGCUGAUUGCUAAUAGUACCAAUCACUAACCACACAGCCAGGUAAAAAGACU	MIMAT0000381 mmu-miR-34c-5p	AGGCAGUGUAGUUAGCUGAUUGC	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences.
MI0000403	MIPF0000039	AGUCUAGUUACUAGGCAGUGUAGUUAGCUGAUUGCUAAUAGUACCAAUCACUAACCACACAGCCAGGUAAAAAGACU	MIMAT0004580 mmu-miR-34c-3p	AAUCACUAACCACACAGCCAGG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0000685 hsa-miR-34b-5p	UAGGCAGUGUCAUUAGCUGAUUG	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.
MI0000742	MIPF0000039	GUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCAC	MIMAT0004676 hsa-miR-34b-3p	CAAUCACUAACUCCACUGCCAU	Houbaviy et al. cloned 3 closely related sequences from mouse embryonicstem cells , and named them miR-34a, miR-34b and miR-172. These nameshave been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) andmiR-34a (MIR:MI0000584) to clarify homology with human sequences. Thepredominant mature miRNA in human is expressed from the 3' arm (incontrast to previous annotation) . Both arms express mature productsin mouse.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

AXL,CDK4,VEGFA,MYCN,AKT1,PARK7,MYC,ACSL1,CCND1,ENOSF1,BCL2,MET,SOX2,HNF4A,MYB
more » AXL,CDK4,VEGFA,MYCN,AKT1,PARK7,MYC,ACSL1,CCND1,ENOSF1,BCL2,MET,SOX2,HNF4A,MYB,SRSF2,JAG1,ZAP70,CDK4PS,CCNE2,CDK6,PARK2,CREB1,NOTCH1,CAV1

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05222	Small cell lung cancer	CCND1,CDK6,CCNE2,BCL2,CDK4,AKT1,MYC,	2.68E-7
hsa05200	Pathways in cancer	CCND1,CDK6,CCNE2,BCL2,VEGFA,CDK4,MET,AKT1,MYC,	6.80E-6
hsa05218	Melanoma	CCND1,CDK6,CDK4,MET,AKT1,	9.21E-5
hsa05212	Pancreatic cancer	CCND1,CDK6,VEGFA,CDK4,AKT1,	9.73E-5
hsa05220	Chronic myeloid leukemia	CCND1,CDK6,CDK4,AKT1,MYC,	1.14E-4

hsa05210	Colorectal cancer	CCND1,BCL2,MET,AKT1,MYC,	1.77E-4
hsa05215	Prostate cancer	CCND1,CCNE2,BCL2,CREB1,AKT1,	2.22E-4
hsa05219	Bladder cancer	CCND1,VEGFA,CDK4,MYC,	3.92E-4
hsa04510	Focal adhesion	CCND1,BCL2,VEGFA,CAV1,MET,AKT1,	5.16E-4
hsa04110	Cell cycle	CCND1,CDK6,CCNE2,CDK4,MYC,	8.15E-4
hsa05223	Non-small cell lung cancer	CCND1,CDK6,CDK4,AKT1,	8.25E-4
hsa05214	Glioma	CCND1,CDK6,CDK4,AKT1,	1.29E-2
hsa04115	p53 signaling pathway	CCND1,CDK6,CCNE2,CDK4,	1.61E-2
hsa05213	Endometrial cancer	CCND1,AKT1,MYC,	1.41E-1
hsa05221	Acute myeloid leukemia	CCND1,AKT1,MYC,	1.74E-1
hsa05211	Renal cell carcinoma	VEGFA,MET,AKT1,	2.47E-1
hsa04660	T cell receptor signaling pathway	ZAP70,CDK4,AKT1,	5.48E-1
hsa05216	Thyroid cancer	CCND1,MYC,	9.79E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0042127	regulation of cell proliferation	CCND1,ZAP70,SOX2,BCL2,NOTCH1,CDK4,CAV1,CDK6,MYCN,JAG1,HNF4A,VEGFA,MYC,	1.95E-9
GO:0008284	positive regulation of cell proliferation	ZAP70,SOX2,CCND1,CDK6,BCL2,MYCN,VEGFA,NOTCH1,CDK4,MYC,	1.87E-8
GO:0010604	positive regulation of macromolecule metabolic process	SOX2,CCND1,HNF4A,BCL2,VEGFA,NOTCH1,CDK4,CAV1,CREB1,AKT1,MYC,	8.57E-7
GO:0051726	regulation of cell cycle	CCND1,CDK6,CCNE2,HNF4A,BCL2,CDK4,AKT1,MYC,	1.19E-6
GO:0009991	response to extracellular stimulus	SOX2,CCND1,ACSL1,BCL2,AXL,CAV1,AKT1,	1.82E-6

GO:0006468	protein amino acid phosphorylation	ZAP70,CCND1,CDK6,BCL2,AXL,CDK4,CREB1,MET,AKT1,	1.21E-5
GO:0031667	response to nutrient levels	SOX2,CCND1,ACSL1,BCL2,CAV1,AKT1,	2.11E-5
GO:0051329	interphase of mitotic cell cycle	CCND1,CDK6,BCL2,CDK4,AKT1,	2.99E-5
GO:0042493	response to drug	CCND1,PARK7,ACSL1,BCL2,CAV1,CREB1,	3.28E-5
GO:0045596	negative regulation of cell differentiation	SOX2,CCND1,CDK6,JAG1,NOTCH1,CAV1,	3.28E-5
GO:0051325	interphase	CCND1,CDK6,BCL2,CDK4,AKT1,	3.35E-5
GO:0045597	positive regulation of cell differentiation	ZAP70,SOX2,BCL2,JAG1,NOTCH1,AKT1,	4.34E-5
GO:0032844	regulation of homeostatic process	CDK6,BCL2,VEGFA,CAV1,MYC,	4.46E-5
GO:0016310	phosphorylation	ZAP70,CCND1,CDK6,BCL2,AXL,CDK4,CREB1,MET,AKT1,	4.54E-5
GO:0019217	regulation of fatty acid metabolic process	ACSL1,HNF4A,CAV1,AKT1,	8.56E-5
GO:0048732	gland development	SOX2,BCL2,CAV1,CREB1,MET,	8.63E-5
GO:0007584	response to nutrient	SOX2,CCND1,ACSL1,BCL2,CAV1,	9.94E-5
GO:0010557	positive regulation of macromolecule biosynthetic process	SOX2,HNF4A,VEGFA,NOTCH1,CDK4,CREB1,AKT1,MYC,	1.00E-4
GO:0051094	positive regulation of developmental process	ZAP70,SOX2,BCL2,JAG1,NOTCH1,AKT1,	1.09E-4
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,BCL2,CDK4,AKT1,	1.27E-4
GO:0042325	regulation of phosphorylation	CCND1,CCNE2,HNF4A,BCL2,CAV1,MET,AKT1,	1.28E-4
GO:0031328	positive regulation of cellular biosynthetic process	SOX2,HNF4A,VEGFA,NOTCH1,CDK4,CREB1,AKT1,MYC,	1.34E-4
GO:0010565	regulation of cellular ketone metabolic process	ACSL1,HNF4A,CAV1,AKT1,	1.34E-4
GO:0009891	positive regulation of biosynthetic process	SOX2,HNF4A,VEGFA,NOTCH1,CDK4,CREB1,AKT1,MYC,	1.47E-4
GO:0019220	regulation of phosphate metabolic process	CCND1,CCNE2,HNF4A,BCL2,CAV1,MET,AKT1,	1.59E-4
GO:0051174	regulation of phosphorus metabolic process	CCND1,CCNE2,HNF4A,BCL2,CAV1,MET,AKT1,	1.59E-4
GO:0048609	reproductive process in a multicellular organism	BCL2,VEGFA,NOTCH1,CAV1,CREB1,MET,AKT1,	1.63E-4
GO:0032504	multicellular organism reproduction	BCL2,VEGFA,NOTCH1,CAV1,CREB1,MET,AKT1,	1.63E-4
GO:0006793	phosphorus metabolic process	ZAP70,CCND1,CDK6,BCL2,AXL,CDK4,CREB1,MET,AKT1,	1.80E-4
GO:0006796	phosphate metabolic process	ZAP70,CCND1,CDK6,BCL2,AXL,CDK4,CREB1,MET,AKT1,	1.80E-4
GO:0010033	response to organic substance	CCND1,ACSL1,HNF4A,BCL2,CAV1,CREB1,AKT1,MYC,	1.84E-4
GO:0048754	branching morphogenesis of a tube	BCL2,MYCN,VEGFA,NOTCH1,	1.99E-4
GO:0031099	regeneration	CCND1,BCL2,AXL,NOTCH1,	2.38E-4
GO:0001763	morphogenesis of a branching structure	BCL2,MYCN,VEGFA,NOTCH1,	2.92E-4
GO:0009314	response to radiation	CCND1,BCL2,CAV1,AKT1,MYC,	3.90E-4
GO:0009628	response to abiotic stimulus	SOX2,CCND1,BCL2,CAV1,AKT1,MYC,	4.02E-4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	4.17E-4
GO:0008361	regulation of cell size	HNF4A,BCL2,CDK4,CREB1,AKT1,	4.36E-4
GO:0009968	negative regulation of signal transduction	SOX2,CCND1,HNF4A,CAV1,AKT1,	5.69E-4
GO:0043583	ear development	SOX2,BCL2,JAG1,MYC,	6.10E-4
GO:0007423	sensory organ development	SOX2,BCL2,JAG1,VEGFA,MYC,	6.51E-4
GO:0008633	activation of pro-apoptotic gene products	BCL2,AKT1,MYC,	6.81E-4
GO:0032270	positive regulation of cellular protein metabolic process	CCND1,BCL2,CDK4,CAV1,AKT1,	6.94E-4
GO:0030097	hemopoiesis	ZAP70,CDK6,BCL2,JAG1,VEGFA,	7.29E-4
GO:0051173	positive regulation of nitrogen compound metabolic process	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,AKT1,MYC,	7.32E-4
GO:0051247	positive regulation of protein metabolic process	CCND1,BCL2,CDK4,CAV1,AKT1,	8.13E-4
GO:0001568	blood vessel development	JAG1,VEGFA,NOTCH1,CAV1,AKT1,	8.38E-4
GO:0010648	negative regulation of cell communication	SOX2,CCND1,HNF4A,CAV1,AKT1,	8.77E-4
GO:0040018	positive regulation of multicellular organism growth	BCL2,CREB1,AKT1,	8.82E-4
GO:0060541	respiratory system development	SOX2,MYCN,VEGFA,NOTCH1,	8.86E-4
GO:0030182	neuron differentiation	SOX2,BCL2,JAG1,VEGFA,NOTCH1,CREB1,	8.87E-4
GO:0001944	vasculature development	JAG1,VEGFA,NOTCH1,CAV1,AKT1,	9.17E-4
GO:0019216	regulation of lipid metabolic process	ACSL1,HNF4A,CAV1,AKT1,	9.85E-4
GO:0048534	hemopoietic or lymphoid organ development	ZAP70,CDK6,BCL2,JAG1,VEGFA,	1.04E-2
GO:0003006	reproductive developmental process	SOX2,CCND1,BCL2,VEGFA,AKT1,	1.07E-2
GO:0007595	lactation	CAV1,CREB1,MET,	1.10E-2
GO:0030856	regulation of epithelial cell differentiation	CCND1,NOTCH1,CAV1,	1.18E-2
GO:0032535	regulation of cellular component size	HNF4A,BCL2,CDK4,CREB1,AKT1,	1.22E-2
GO:0032268	regulation of cellular protein metabolic process	CCND1,HNF4A,BCL2,CDK4,CAV1,AKT1,	1.26E-2
GO:0045893	positive regulation of transcription, DNA-dependent	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	1.30E-2
GO:0002520	immune system development	ZAP70,CDK6,BCL2,JAG1,VEGFA,	1.30E-2
GO:0051254	positive regulation of RNA metabolic process	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	1.35E-2
GO:0008637	apoptotic mitochondrial changes	BCL2,AKT1,MYC,	1.35E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	SOX2,HNF4A,MYCN,VEGFA,NOTCH1,CREB1,MYC,	1.37E-2
GO:0045137	development of primary sexual characteristics	SOX2,CCND1,BCL2,VEGFA,	1.41E-2
GO:0035239	tube morphogenesis	BCL2,MYCN,VEGFA,NOTCH1,	1.41E-2
GO:0042592	homeostatic process	PARK7,HNF4A,BCL2,VEGFA,CAV1,AKT1,MYC,	1.63E-2
GO:0051301	cell division	CCND1,CDK6,CCNE2,NOTCH1,CDK4,	1.66E-2
GO:0009967	positive regulation of signal transduction	ZAP70,SOX2,JAG1,VEGFA,CAV1,	1.66E-2
GO:0048878	chemical homeostasis	PARK7,HNF4A,BCL2,VEGFA,CAV1,MYC,	1.78E-2
GO:0010741	negative regulation of protein kinase cascade	HNF4A,CAV1,AKT1,	1.83E-2
GO:0045165	cell fate commitment	SOX2,BCL2,JAG1,NOTCH1,	1.83E-2
GO:0043085	positive regulation of catalytic activity	CCND1,BCL2,CAV1,MET,AKT1,MYC,	1.90E-2
GO:0007049	cell cycle	CCND1,CDK6,CCNE2,BCL2,CDK4,AKT1,MYC,	1.92E-2
GO:0007548	sex differentiation	SOX2,CCND1,BCL2,VEGFA,	2.32E-2
GO:0007346	regulation of mitotic cell cycle	CCND1,HNF4A,BCL2,MYC,	2.36E-2
GO:0010647	positive regulation of cell communication	ZAP70,SOX2,JAG1,VEGFA,CAV1,	2.48E-2
GO:0022405	hair cycle process	BCL2,NOTCH1,AKT1,	2.48E-2
GO:0022404	molting cycle process	BCL2,NOTCH1,AKT1,	2.48E-2
GO:0001942	hair follicle development	BCL2,NOTCH1,AKT1,	2.48E-2
GO:0051899	membrane depolarization	PARK7,BCL2,CAV1,	2.60E-2
GO:0042303	molting cycle	BCL2,NOTCH1,AKT1,	2.60E-2
GO:0042633	hair cycle	BCL2,NOTCH1,AKT1,	2.60E-2
GO:0045941	positive regulation of transcription	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	2.72E-2
GO:0022402	cell cycle process	CCND1,CDK6,BCL2,CDK4,AKT1,MYC,	2.74E-2
GO:0007167	enzyme linked receptor protein signaling pathway	VEGFA,AXL,CREB1,MET,AKT1,	2.85E-2
GO:0045859	regulation of protein kinase activity	CCND1,CCNE2,CAV1,MET,AKT1,	2.94E-2
GO:0010628	positive regulation of gene expression	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	3.09E-2
GO:0030334	regulation of cell migration	BCL2,JAG1,VEGFA,AKT1,	3.19E-2
GO:0044093	positive regulation of molecular function	CCND1,BCL2,CAV1,MET,AKT1,MYC,	3.21E-2
GO:0043066	negative regulation of apoptosis	BCL2,VEGFA,NOTCH1,AKT1,MYC,	3.23E-2
GO:0043549	regulation of kinase activity	CCND1,CCNE2,CAV1,MET,AKT1,	3.33E-2
GO:0043069	negative regulation of programmed cell death	BCL2,VEGFA,NOTCH1,AKT1,MYC,	3.40E-2
GO:0001932	regulation of protein amino acid phosphorylation	CCND1,HNF4A,BCL2,CAV1,	3.41E-2
GO:0060548	negative regulation of cell death	BCL2,VEGFA,NOTCH1,AKT1,MYC,	3.43E-2
GO:0051934	catecholamine uptake during transmission of nerve impulse	PARK7,PARK2,	3.54E-2
GO:0051583	dopamine uptake	PARK7,PARK2,	3.54E-2
GO:0000278	mitotic cell cycle	CCND1,CDK6,BCL2,CDK4,AKT1,	3.79E-2
GO:0051338	regulation of transferase activity	CCND1,CCNE2,CAV1,MET,AKT1,	3.86E-2
GO:0008544	epidermis development	BCL2,JAG1,NOTCH1,AKT1,	4.05E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CCNE2,AKT1,	4.08E-2
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	SOX2,HNF4A,VEGFA,NOTCH1,CREB1,MYC,	4.20E-2
GO:0009612	response to mechanical stimulus	SOX2,CAV1,MYC,	4.38E-2
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	HNF4A,NOTCH1,CREB1,	4.53E-2
GO:0040012	regulation of locomotion	BCL2,JAG1,VEGFA,AKT1,	4.57E-2
GO:0051270	regulation of cell motion	BCL2,JAG1,VEGFA,AKT1,	4.64E-2
GO:0009411	response to UV	CCND1,BCL2,AKT1,	4.85E-2
GO:0010212	response to ionizing radiation	CCND1,BCL2,CAV1,	5.01E-2
GO:0007398	ectoderm development	BCL2,JAG1,NOTCH1,AKT1,	5.05E-2
GO:0040014	regulation of multicellular organism growth	BCL2,CREB1,AKT1,	5.17E-2
GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein	HNF4A,CAV1,	5.31E-2
GO:0070141	response to UV-A	CCND1,AKT1,	5.31E-2
GO:0010035	response to inorganic substance	CCND1,PARK7,BCL2,CAV1,	5.48E-2
GO:0030879	mammary gland development	CAV1,CREB1,MET,	5.51E-2
GO:0006916	anti-apoptosis	BCL2,VEGFA,AKT1,MYC,	5.56E-2
GO:0022403	cell cycle phase	CCND1,CDK6,BCL2,CDK4,AKT1,	5.65E-2
GO:0046546	development of primary male sexual characteristics	SOX2,CCND1,BCL2,	5.86E-2
GO:0048514	blood vessel morphogenesis	JAG1,VEGFA,NOTCH1,CAV1,	5.94E-2
GO:0010608	posttranscriptional regulation of gene expression	BCL2,VEGFA,CDK4,AKT1,	5.94E-2
GO:0033273	response to vitamin	SOX2,CCND1,BCL2,	6.03E-2
GO:0010720	positive regulation of cell development	SOX2,BCL2,NOTCH1,	6.58E-2
GO:0035295	tube development	BCL2,MYCN,VEGFA,NOTCH1,	6.67E-2
GO:0008283	cell proliferation	BCL2,VEGFA,NANOG,MET,MYC,	6.77E-2
GO:0050678	regulation of epithelial cell proliferation	CDK6,VEGFA,NOTCH1,	6.95E-2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	VEGFA,AXL,MET,AKT1,	7.01E-2
GO:0046661	male sex differentiation	SOX2,CCND1,BCL2,	7.34E-2
GO:0030278	regulation of ossification	SOX2,CDK6,BCL2,	8.34E-2
GO:0051384	response to glucocorticoid stimulus	CCND1,BCL2,CAV1,	8.34E-2
GO:0045927	positive regulation of growth	BCL2,CREB1,AKT1,	8.76E-2
GO:0015872	dopamine transport	PARK7,PARK2,	8.84E-2
GO:0045747	positive regulation of Notch signaling pathway	SOX2,JAG1,	8.84E-2
GO:0051240	positive regulation of multicellular organismal process	BCL2,CAV1,CREB1,AKT1,	8.86E-2
GO:0010959	regulation of metal ion transport	BCL2,CAV1,AKT1,	8.97E-2
GO:0045786	negative regulation of cell cycle	CDK6,HNF4A,BCL2,	8.97E-2
GO:0006355	regulation of transcription, DNA-dependent	SOX2,MYB,HNF4A,MYCN,VEGFA,NANOG,NOTCH1,CREB1,MYC,	9.02E-2
GO:0046777	protein amino acid autophosphorylation	ZAP70,MET,AKT1,	9.84E-2
GO:0031960	response to corticosteroid stimulus	CCND1,BCL2,CAV1,	9.84E-2
GO:0030534	adult behavior	PARK7,PARK2,MET,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value