ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-30

MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000087 hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000088 hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000736	MIPF0000005	ACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGA	MIMAT0000244 hsa-miR-30c-5p	UGUAAACAUCCUACACUCUCAGC	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later validated in humanHL-60 leukemia cells .
	MIPF0001858		MIMAT000024
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000087 hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000088 hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000736	MIPF0000005	ACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGA	MIMAT0000244 hsa-miR-30c-5p	UGUAAACAUCCUACACUCUCAGC	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later validated in humanHL-60 leukemia cells .
	MIPF0001858		MIMAT000024
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000087 hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000088 hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000736	MIPF0000005	ACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGA	MIMAT0000244 hsa-miR-30c-5p	UGUAAACAUCCUACACUCUCAGC	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later validated in humanHL-60 leukemia cells .
MI0000254	MIPF0000005	AGAUACUGUAAACAUCCUACACUCUCAGCUGUGGAAAGUAAGAAAGCUGGGAGAAGGCUGUUUACUCUUUCU	MIMAT0004550 hsa-miR-30c-2-3p	CUGGGAGAAGGCUGUUUACUCU	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later independentlyverified in human HL-60 leukemia cells .
MI0000255	MIPF0000005	GUUGUUGUAAACAUCCCCGACUGGAAGCUGUAAGACACAGCUAAGCUUUCAGUCAGAUGUUUGCUGCUAC	MIMAT0000245 hsa-miR-30d-5p	UGUAAACAUCCCCGACUGGAAG
MI0000255	MIPF0000005	GUUGUUGUAAACAUCCCCGACUGGAAGCUGUAAGACACAGCUAAGCUUUCAGUCAGAUGUUUGCUGCUAC	MIMAT0004551 hsa-miR-30d-3p	CUUUCAGUCAGAUGUUUGCUGC
MI0000441	MIPF0000005	ACCAAGUUUCAGUUCAUGUAAACAUCCUACACUCAGCUGUAAUACAUGGAUUGGCUGGGAGGUGGAUGUUUACUUCAGCUGACUUGGA	MIMAT0000420 hsa-miR-30b-5p	UGUAAACAUCCUACACUCAGCU	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse , later verified in human .
MI0000441	MIPF0000005	ACCAAGUUUCAGUUCAUGUAAACAUCCUACACUCAGCUGUAAUACAUGGAUUGGCUGGGAGGUGGAUGUUUACUUCAGCUGACUUGGA	MIMAT0004589 hsa-miR-30b-3p	CUGGGAGGUGGAUGUUUACUUC	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse , later verified in human .
MI0000736	MIPF0000005	ACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGA	MIMAT0004674 hsa-miR-30c-1-3p	CUGGGAGAGGGUUGUUUACUCC	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later validated in humanHL-60 leukemia cells .
MI0000749	MIPF0000005	GGGCAGUCUUUGCUACUGUAAACAUCCUUGACUGGAAGCUGUAAGGUGUUCAGAGGAGCUUUCAGUCGGAUGUUUACAGCGGCAGGCUGCCA	MIMAT0000692 hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGAAG	This sequence is the predicted human homologue of mouse miR-30e [1,2,4].Mature products from both arms of the precursor (hsa-miR-30e-5p andhsa-miR-30e-3p) were later independently verified in human myelocyticleukemia (HL-60) cells . Landgraf et al. later showed that the 5'product is the predominant one . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000749	MIPF0000005	GGGCAGUCUUUGCUACUGUAAACAUCCUUGACUGGAAGCUGUAAGGUGUUCAGAGGAGCUUUCAGUCGGAUGUUUACAGCGGCAGGCUGCCA	MIMAT0000693 hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC	This sequence is the predicted human homologue of mouse miR-30e [1,2,4].Mature products from both arms of the precursor (hsa-miR-30e-5p andhsa-miR-30e-3p) were later independently verified in human myelocyticleukemia (HL-60) cells . Landgraf et al. later showed that the 5'product is the predominant one . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000087 hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000088	MIPF0000005	GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC	MIMAT0000088 hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC	The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).
MI0000736	MIPF0000005	ACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGA	MIMAT0000244 hsa-miR-30c-5p	UGUAAACAUCCUACACUCUCAGC	miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana etal. . Two human hairpin precursor sequences are predicted based onhomology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6(MIR:MI0000254) . Expression of miR-30c was later validated in humanHL-60 leukemia cells .
	MIPF0001858		MIMAT000024

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

THOC5,CDCP1,CCDC117,RAD23B,MRE11A,PPP2R2B,HMBOX1,LIMA1,UXT,EHMT1,GABARAPL2,INTS6,PNKD,RAB22A,TUBA1B
more » THOC5,CDCP1,CCDC117,RAD23B,MRE11A,PPP2R2B,HMBOX1,LIMA1,UXT,EHMT1,GABARAPL2,INTS6,PNKD,RAB22A,TUBA1B,RPS27A,INPP5F,KLHDC5,SMAD1,NMT1,MTCH2,CEP152,LRRFIP1,POLR3H,ITGA6,LNPEP,TRIO,TNPO3,PABPC1,PPA1,SCN11A,GATAD2B,IFRD1,AGGF1,BDP1,STX17,TRIM37,KPNA1,EP300,STARD7,MGST2,LCLAT1,RELA,MGLL,MLL2,DNAJB14,MAT2A,FAM47E,XPO1,CORO1C,THUMPD1,TGIF2,EZH2,LRRN1,HUWE1,BAX,LTN1,RAPGEFL1,RORC,PDLIM7,STAU1,ITGA4,LLPH,PICALM,ANXA1,GLRX,SRSF9,YTHDC2,SLC33A1,SLC9A3R2,TGM2,VPS13B,RBMS3,NFE2L1,REXO2,POU4F1,FKTN,PBRM1,HUS1,DYRK1B,HPRT1,ADAP2,RUNX2,NCKAP1,POLDIP3,LYRM2,C1QBP,GALNT1,ZBTB38,RBM3,TICAM2,CYB5B,DDX10,CPSF7,ATP6V1B2,TIMM9,RPS17,PSMA6,GPD2,BCL6,PRPF19,PARP1,MARCH5,EXO1,UHRF2,HEY1,MKI67IP,HECTD1,PDAP1,TMX3,ARF1,SEC63,TBCB,MARK4,CPNE8,SNX3,PGM3,FAM134C,RPRD1A,ARHGEF12,PLDN,RPLP0,RAB18,DOCK7,FBN1,ATP5O,UBE2I,CD2AP,AGPAT5,IRF2,TRA2B,SMARCE1,GPRC5A,CSNK1E,C16orf70,GZF1,HIC2,PPP2R5C,TNFRSF10D,BLMH,WDR89,HNRNPA1,HEATR2,RNF34,THBS1,GDI2,WDR43,NFYB,EXOSC2,RREB1,TM9SF1,NDNL2,GTF3C4,ZBTB4,TWF1,HNRNPC,CBY1,TRIM28,HDAC4,SLC4A7,KIAA0564,PRPF4B,HMG20A,PHLDA2,ABL1,MED1,PNPO,BMS1,MACF1,KIF11,NUP98,SEC24B,DDX50,DDB1,UBL3,FAF2,ATRX,MTDH,LRRC8C,CASC4,HNRNPU,TMEM59,CDCA7,TMCO1,NIP7,FAM96A,CCT6A,POLRMT,SERPINE2,NEDD9,KRT85,SCD,UBE2O,LIMCH1,TRA2A,EIF2A,UFM1,MGAT2,UAP1,FSCN1,FDPS,TNKS2,YWHAZ,CANX,ARG1,SGTA,ZNF687,SOCS1,TMEM120B,GNG5,NXT1,SMU1,OGDH,SOCS3,ANPEP,TIAL1,ARHGEF6,DARS2,PIP4K2A,KIF5B,NPR3,FMR1,PNMA2,PGM1,CTSL1,STARD5,ND6,RPS12,TMED7,DNAJC3,NT5C3,C10orf137,AVEN,MLLT11,HINT3,WDR12,POLR2C,ARF6,LONP2,MUC17,RPUSD4,GRPEL2,HIST1H1A,KIAA1671,SLC38A5,AZIN1,SERBP1,CARS2,MYO10,MYBL2,FRG1,MATR3,ATP5C1,PTAR1,NDE1,ZNF207,EFTUD1,HSPA1A,TMED1,ATP2A2,ERI1,ACSL4,RAB27B,CNP,KRT7,RNPS1,RPP40,PAM,TNRC6C,MAN1A2,WDR37,ETS1,RSRC1,CAPN2,TTLL12,HNRNPM,PPP3CA,RBBP7,APLN,SNAI1,ARID3A,OTP,EIF2S3,HK1,TSHZ3,GPBP1L1,GNPDA1,DENND5A,DHX33,PFN1,CCPG1,PTPRK,ACTR10,GMFB,ATG12,ERP44,ESYT1,P4HA2,PAFAH1B2,FAM60A,SARS,GTF2H1,NT5E,SUCLA2,UTP15,CSF1,PRMT7,ARCN1,DPY19L1,REXO4,MAP2K1,B3GNT5,SEC11A,ZNF295,MYO1E,ZFPL1,CDC20,ATP1A1,ITGA2,OTUD7A,ZNF589,ZNF146,RPS8,RRP15,ARHGAP44,EIF1,CD44,TUBB3,DYNC1LI1,FXR2,ATL2,SPCS3,NDFIP1,TBC1D4,DNAJB4,TMEM41B,KLC2,DLC1,CNPY4,EXOC2,NONO,SNTB2,GALNT7,SKIL,HSPH1,DROSHA,HSPA14,ZNF418,TMED2,USE1,PLCB1,LYRM7,RASA1,CSNK1G1,PPP3R1,NT5C1B,PLA2G4A,SUZ12,CAST,RAC1,C1orf55,TAOK1,MRPL28,HSPA4,POLQ,SLC25A12,MLH1,NEDD4,COPS7B,LARP4B,CSDA,VAMP3,NUCB1,MPDU1,CLDN12,REXO1,SLC25A38,DHX36,PTMS,BECN1,KREMEN1,SNAPC4,NDUFV3,NFU1,ITPRIPL2,SLC38A1,PTRH1,RRM2,SOX4,UTP11L,CXXC4,AK2,YKT6,XPO7,SLC12A4,SRRT,C16orf62,KCNN4,CAPZA1,BCL2,CPSF3L,ABCE1,EPT1,EGFR,GLCE,MYBBP1A,NFKBIA,YOD1,SMEK1,HNRPDL,GFPT2,CHD1,PSME4,RAB34,RPN2,CPSF3,MET,TMEM87A,OLFML2B,SLC39A8,TOMM5,ZYG11A,TAB1,CAMKV,DNAJA4,EIF2C1,GPR78,SAMD4B,UBE2H,CUL2,NR2F6,ATP6V1C1,PTP4A1,KRT77,LACTB2,NAPG,CPSF1,C11orf61,IFRD2,ZNF638,ZFYVE20,HDAC1,PARVG,RPS3,G3BP1,AIFM1,BTBD9,HOXA11,RBM34,TNFAIP2,CADPS2,CPSF4,TGFBI,STUB1,RBM5,AP2A1,CDH2,GTF2H2C,GLRX3,CDH1,MTA1,RPRD1B,SMARCA1,E2F3,CIRBP,RPS4X,RPS7,WDR5,EED,RRP36,PDCD10,PHF13,THEM4,GTF2H2,PRPF40A,LSM12,PPM1H,TPBG,STX7,NLE1,MAP2K3,UBE2NL,RBM14,CTNNB1,ITGB3,ATOX1,MARCKSL1,LSS,MTPAP,RRAGD,PHB2,DNAJB1,FBLN1,CKAP4,RGMB,TRIM59,BCCIP,TP53,TM9SF3,SEMA6A,FDX1,TOM1,NDEL1,ZNF780B,VIM,DAG1,TAPBP,KLF4,GALNTL2,FAHD1,SCD5,EIF2C2,PPP1CC,URM1,ACP2,MOSPD2,FERMT2,HAGH,DDAH1,LMNB2,NOP14,HNRNPK,ZDHHC17,LDLR,ANKRD26,GAPVD1,ZNF646,KLF10,SON,CBFB,PRIM1,TRRAP,PPP2R4,JUP,PRKAA1,SLC7A11,SCAF1,ARPC5,RPL39,MGEA5,KCTD3,FXR1,HMGN2,DERL1,CAT,ASCC3,MTHFD2,KLF14,MPP2,CNDP2,PLIN3,ESRRA,BCL2L1,RHOF,TMEM14E,STRN,PPID,ARF3,CDC123,CLSTN1,EML4,DDOST,DGCR8,EIF2B1,FTSJ1,TKT,FAM8A1,PPIA,FEM1B,MAZ,SMCHD1,LIN28A,ACER3,ZNF609,RETSAT,TIMP3,RPL32,NAA25,MTX3,RARS2,ABCB10,MAP1LC3B,RAB35,ZNF567,ZNF829,SNRNP200,TMEM2,PITPNB,COPS7A,SMN2,BAZ1B,PPP1R12A,UBXN1,HNRNPH1,TIMM10,DTL,EEF2,SLC12A2,CSNK1G3,TMEM106B,ERLIN1,FOXD1,KLHL15,SIAH2,CCNE2,ZNF506,SOD2,USP5,HNRNPA2B1,ZNF770,ADC,POU2F1,ALDH5A1,IKZF4,PTBP3,MAPK1,KDELC2,RPIA,DNAJC2,TRIP12,SCYL1,WDR26,HMGXB4,NOL9,DIS3,ELOVL5,TBL1XR1,MIER1,EIF2B4,RND3,RAB14,WDR74,DHX8,PIK3CD,CDK6,MCL1,CARS,PRMT1,YRDC,TMED3,SH2B3,JUN,SDCBP,IMPDH2,FBN2,SENP2,RHOB,TMCO3,TIMM8A,SENP3,TRERF1,TUBB4B,RAB21,KRT6B,RFX7,C1D,ZNF668,MAP4K4,ECT2,DNAJA1,GNG2,PES1,RPP14,RBMS1,MRPS16,GNA13,LRP8,TPI1,ME3,MED28,MBNL1,POM121,FBXO3,UTP6,TMED5,GATC,CTSC,PAICS,CLEC4D,MSL2,NEUROD1,GNB2L1,NDUFAF1,KLHL28,OGFOD1,CFL2,SF3B3,CHAT,HMGA1,NUFIP2,LIN9,PCNA,DCAF12,PIK3R2,HERC4,STX16,IDH1,MED13,KIAA1609,MRPL38,PRKCDBP,CTNND1,NUDT11,CHMP4C,TMEM192,PSMB5,HNRNPA1L2,ITPRIP,FNDC3B,IGF1R,TRAPPC9,MAP1LC3B2,KRAS,VAC14,SMN1,SHFM1,PPP1R12B,RBFOX2,PPP2R2A,SLC7A2,CSDE1,GNAZ,SEC24A,TUBA1A,CPOX,TIMM17A,USP53,AP2S1,AP3S1,SLC7A6,SLC4A10,HSP90AA1,SNX2,TNFRSF10B,PPOX,KPNA4,BIRC5,OTUD4,ITGB4,SNRNP40,PRKAB2,IKBIP,YWHAE,RAC3,ELMOD2,ZNF543,PAK1IP1,DNMT1,NOL12,EYA3,NOL8,MCFD2,MAK16,ATP8A2,SH3GL1,GGCT,TMED10,CEP72,SERPINE1,IPO9,TBC1D9B,WDR75,ANAPC5,APEH,MAN2B1,GLIPR1,CYR61,GTF3C3,GNAI2,TBC1D8B,SEC11C,VEZT,PKM2,KIDINS220,ELOVL4,KCTD12,ADPGK,PAIP2,NIPBL,NCOA6,SHC1,ATXN10,SEC23A,PTBP1,ZNF227,PNN,XPOT,SLC27A1,MXI1,RTN4,SDF2L1,REEP5,EEF1A1,PPP1R10,NOTCH1,UQCRC1,RPL27A,EXOSC10,SGSH,TTC19,SERPINB5,USP16,CASP3,HDGF,UGDH,DPYSL2,LSM1,WDR82,C1orf123,PTGFRN,LRRC42,LARP4,TNRC6A,TAF1C,RBFOX1,MEF2A,KBTBD6,SAMD9,LIG3,FNIP1,PYCR2,UBE3C,NCEH1,ZNF324,POLR2B,ABI2,ERLIN2,PRDM1,SEPT7,CNO,PEX11B,NAP1L1,PCNT,CELSR3,SLC39A1,PAIP1,WNT5A,SLC38A2,SRPR,NCL,RFT1,HDHD3,METTL21D,USP37,SEC62,MIER3,DSG2,SAMHD1,SUN2,TELO2,SYPL1,CSNK1G2,MAP1B,HSPA1B,RQCD1,ARFGAP1,NACC2,FRZB,PRCP,OSBPL8,UBE2D2,C5orf15

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05210	Colorectal cancer	JUN,BCL2,RAC3,MLH1,EGFR,MAP2K1,BAX,BIRC5,KRAS,TP53,CASP3,CTNNB1,IGF1R,PIK3CD,MET,RAC1,PIK3R2,MAPK1,	4.04E-6
hsa05215	Prostate cancer	BCL2,EGFR,EP300,RELA,MAP2K1,KRAS,E2F3,TP53,CTNNB1,IGF1R,CCNE2,PIK3CD,HSP90AA1,NFKBIA,PIK3R2,MAPK1,	1.40E-4
hsa05212	Pancreatic cancer	RAC3,BCL2L1,ARHGEF6,EGFR,RELA,MAP2K1,KRAS,TP53,E2F3,CDK6,PIK3CD,RAC1,PIK3R2,MAPK1,	1.92E-4
hsa05220	Chronic myeloid leukemia	BCL2L1,SHC1,RELA,MAP2K1,KRAS,ABL1,TP53,E2F3,CDK6,PIK3CD,HDAC1,NFKBIA,PIK3R2,MAPK1,	2.94E-4
hsa04210	Apoptosis	CAPN2,BCL2,BCL2L1,BAX,RELA,TP53,CASP3,PPP3R1,PPP3CA,PIK3CD,TNFRSF10D,TNFRSF10B,NFKBIA,AIFM1,PIK3R2,	3.86E-4

hsa05200	Pathways in cancer	JUN,EGFR,EP300,RELA,BIRC5,KRAS,JUP,WNT5A,CTNNB1,IGF1R,HSP90AA1,ITGA6,MET,ITGA2,BCL2,BCL2L1,RAC3,MLH1,MAP2K1,BAX,ABL1,CASP3,E2F3,TP53,CDK6,CCNE2,PIK3CD,CUL2,HDAC1,ETS1,NFKBIA,RAC1,PIK3R2,CDH1,MAPK1,	4.87E-4
hsa04722	Neurotrophin signaling pathway	JUN,BCL2,SHC1,MAP2K1,BAX,RELA,KRAS,ABL1,TP53,PIK3CD,YWHAZ,YWHAE,KIDINS220,NFKBIA,SH2B3,RAC1,PIK3R2,MAPK1,	6.66E-4
hsa05014	Amyotrophic lateral sclerosis (ALS)	DERL1,BCL2,BCL2L1,MAP2K3,BAX,CAT,RAC1,CASP3,TP53,PPP3CA,PPP3R1,	7.36E-4
hsa04120	Ubiquitin mediated proteolysis	HERC4,STUB1,UBE2NL,UBE2I,UBE2H,NEDD4,SOCS1,HUWE1,PRPF19,TRIM37,CUL2,UBE2D2,UBE2O,CDC20,ANAPC5,TRIP12,SOCS3,UBE3C,DDB1,	7.80E-4
hsa05218	Melanoma	IGF1R,CDK6,PIK3CD,EGFR,MAP2K1,KRAS,MET,E2F3,PIK3R2,TP53,CDH1,MAPK1,	2.21E-2
hsa04510	Focal adhesion	JUN,CAPN2,ITGA2,BCL2,RAC3,EGFR,SHC1,MAP2K1,ITGB3,ITGB4,CTNNB1,ITGA4,IGF1R,PIK3CD,PPP1CC,PPP1R12A,MET,RAC1,ITGA6,PIK3R2,THBS1,PARVG,MAPK1,	2.50E-2
hsa05213	Endometrial cancer	PIK3CD,MLH1,EGFR,MAP2K1,KRAS,PIK3R2,TP53,CDH1,CTNNB1,MAPK1,	2.53E-2
hsa04810	Regulation of actin cytoskeleton	ABI2,ITGA2,RAC3,EGFR,ARHGEF6,MAP2K1,ARHGEF12,GNA13,KRAS,ITGB3,ITGB4,CFL2,ITGA4,ARPC5,PIK3CD,PPP1CC,PPP1R12A,NCKAP1,PIP4K2A,RAC1,ITGA6,PFN1,PIK3R2,MAPK1,	2.71E-2
hsa05214	Glioma	IGF1R,CDK6,PIK3CD,EGFR,SHC1,MAP2K1,KRAS,E2F3,PIK3R2,TP53,MAPK1,	2.89E-2
hsa04662	B cell receptor signaling pathway	JUN,PIK3CD,RAC3,RELA,MAP2K1,KRAS,NFKBIA,RAC1,PIK3R2,MAPK1,PPP3CA,PPP3R1,	3.44E-2
hsa05130	Pathogenic Escherichia coli infection	TUBB4B,ARPC5,TUBB3,TUBA1A,YWHAZ,ABL1,NCL,TUBA1B,CDH1,CTNNB1,	4.81E-2
hsa03040	Spliceosome	SNRNP200,HSPA1B,HNRNPM,TRA2B,HSPA1A,SNRNP40,HNRNPA1L2,SF3B3,SRSF9,PRPF19,HNRNPC,HNRNPA1,HNRNPU,DHX8,HNRNPK,PRPF40A,TRA2A,	5.50E-2
hsa05211	Renal cell carcinoma	JUN,PIK3CD,CUL2,EP300,MAP2K1,ETS1,KRAS,MET,RAC1,PIK3R2,MAPK1,	6.29E-2
hsa05222	Small cell lung cancer	CDK6,CCNE2,ITGA2,PIK3CD,BCL2,BCL2L1,RELA,NFKBIA,ITGA6,E2F3,PIK3R2,TP53,	8.25E-2
hsa05219	Bladder cancer	EGFR,MAP2K1,KRAS,E2F3,TP53,THBS1,CDH1,MAPK1,	9.27E-2
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	ITGA4,ITGA2,ITGB3,ITGB4,DSG2,DAG1,ITGA6,JUP,CDH2,ATP2A2,CTNNB1,	1.11E-1
hsa05223	Non-small cell lung cancer	CDK6,PIK3CD,EGFR,MAP2K1,KRAS,E2F3,PIK3R2,TP53,MAPK1,	1.13E-1
hsa04520	Adherens junction	IGF1R,CTNND1,RAC3,EGFR,EP300,MET,SNAI1,RAC1,CDH1,CTNNB1,MAPK1,	1.22E-1
hsa04320	Dorso-ventral axis formation	EGFR,MAP2K1,NOTCH1,ETS1,KRAS,MAPK1,	1.25E-1
hsa04115	p53 signaling pathway	CDK6,CCNE2,TNFRSF10B,BAX,RRM2,SERPINB5,CASP3,SERPINE1,TP53,THBS1,	1.51E-1
hsa05216	Thyroid cancer	MAP2K1,KRAS,TP53,CDH1,CTNNB1,MAPK1,	2.32E-1
hsa03010	Ribosome	RPS8,RPS7,RPL39,RPL32,RPS17,RPS12,RPS4X,RPS3,RPL27A,RPLP0,RPS27A,	2.69E-1
hsa04370	VEGF signaling pathway	PIK3CD,PLA2G4A,RAC3,MAP2K1,KRAS,RAC1,PIK3R2,MAPK1,PPP3CA,PPP3R1,	2.72E-1
hsa04360	Axon guidance	SEMA6A,RAC3,ARHGEF12,KRAS,ABL1,CFL2,PPP3R1,RASA1,PPP3CA,DPYSL2,GNAI2,MET,RAC1,MAPK1,	3.36E-1
hsa00520	Amino sugar and nucleotide sugar metabolism	HK1,UAP1,UGDH,GFPT2,PGM1,GNPDA1,PGM3,	3.87E-1
hsa04720	Long-term potentiation	PLCB1,PPP1CC,EP300,MAP2K1,PPP1R12A,KRAS,MAPK1,PPP3CA,PPP3R1,	4.02E-1
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	JUN,EGFR,RELA,ATP6V1B2,MET,NFKBIA,RAC1,ATP6V1C1,CASP3,	4.02E-1
hsa04730	Long-term depression	IGF1R,GNAI2,GNAZ,PLCB1,PLA2G4A,MAP2K1,GNA13,KRAS,MAPK1,	4.33E-1
hsa04666	Fc gamma R-mediated phagocytosis	ARPC5,PIK3CD,MYO10,PLA2G4A,MAP2K1,ARF6,RAC1,CFL2,PIK3R2,MAPK1,MARCKSL1,	4.55E-1
hsa04114	Oocyte meiosis	IGF1R,CCNE2,PPP1CC,PPP2R5C,MAP2K1,CDC20,YWHAZ,ANAPC5,YWHAE,MAPK1,PPP3CA,PPP3R1,	5.07E-1
hsa04930	Type II diabetes mellitus	HK1,PIK3CD,SOCS3,SOCS1,PKM2,PIK3R2,MAPK1,	5.10E-1
hsa04310	Wnt signaling pathway	JUN,PLCB1,RAC3,EP300,TBL1XR1,CSNK1E,CXXC4,TP53,WNT5A,PPP3R1,PPP3CA,CTNNB1,SENP2,PPP2R5C,RAC1,	5.15E-1
hsa05016	Huntington's disease	PLCB1,SOD2,ATP5C1,EP300,BAX,TP53,NDUFV3,CASP3,PPID,TGM2,AP2A1,ATP5O,HDAC1,POLR2B,POLR2C,AP2S1,UQCRC1,	5.39E-1
hsa04620	Toll-like receptor signaling pathway	JUN,PIK3CD,MAP2K3,RELA,TMED7,MAP2K1,TICAM2,TAB1,NFKBIA,RAC1,PIK3R2,MAPK1,	6.42E-1
hsa04130	SNARE interactions in vesicular transport	YKT6,USE1,STX7,STX16,VAMP3,STX17,	6.48E-1
hsa04540	Gap junction	TUBB4B,GNAI2,PLCB1,TUBB3,TUBA1A,EGFR,MAP2K1,KRAS,TUBA1B,MAPK1,	6.90E-1
hsa04664	Fc epsilon RI signaling pathway	PIK3CD,PLA2G4A,RAC3,MAP2K3,MAP2K1,KRAS,RAC1,PIK3R2,MAPK1,	7.84E-1
hsa04650	Natural killer cell mediated cytotoxicity	RAC3,SHC1,MAP2K1,KRAS,CASP3,PPP3R1,PPP3CA,PIK3CD,TNFRSF10D,TNFRSF10B,RAC1,PIK3R2,MAPK1,	8.01E-1
hsa04960	Aldosterone-regulated sodium reabsorption	PIK3CD,SLC9A3R2,KRAS,ATP1A1,PIK3R2,MAPK1,	8.43E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0006396	RNA processing	EIF2C2,INTS6,HNRNPA1L2,ZNF638,SNRNP40,RBFOX1,RPP40,CPSF4,PRPF19,FRG1,RNPS1,PRMT7,UTP6,EXOSC2,HNRNPU,HNRNPK,TRA2A,MBNL1,CPSF1,SNRNP200,UTP15,NONO,WDR12,PNN,MLH1,RBFOX2,RPS17,SF3B3,SRSF9,HNRNPH1,C1D,HNRNPC,RBMS1,SCAF1,FTSJ1,RBM3,DHX8,HNRNPA2B1,RBM14,SMN2,SMN1,PABPC1,SMAD1,CPSF7,SRRT,SARS,HNRPDL,DROSHA,LSM1,ERI1,PES1,LIN28A,CPSF3,RPP14,HNRNPA1,CPSF3L,DIS3,PRPF40A,URM1,RBM5,PRPF4B,HNRNPM,AGGF1,TRA2B,PTBP3,MTPAP,UTP11L,PTBP1,NOP14,EXOSC10,RPS7,DGCR8,RSRC1,POLR2B,POLR2C,	1.12E-13
GO:0046907	intracellular transport	JUN,STX7,STX16,TIMM10,ATP2A2,YKT6,NUP98,SEC23A,RHOB,NAPG,ATP5O,TIMM17A,XPO7,BCL6,CNO,USE1,SRPR,UXT,SEC63,BAX,MAP2K1,ARCN1,PLDN,ATL2,ARF1,NDE1,AP2A1,MGEA5,TIMM9,KLC2,MTX3,MYO1E,NFKBIA,IPO9,MAPK1,TMED10,LONP2,C16orf70,TOM1,XPO1,TAPBP,NEDD4,KPNA4,RAB14,SEC24B,NDEL1,PPP1R10,NXT1,HSP90AA1,HNRNPA1,SCYL1,GABARAPL2,SNX2,HMGXB4,PCNA,AP2S1,AP3S1,KIF5B,SEC24A,TOMM5,MYBBP1A,ZFYVE20,BCL2,BCL2L1,THOC5,KPNA1,ARFGAP1,RAB35,SLC25A12,TP53,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,RSRC1,SDCBP,YWHAZ,SEC62,YWHAE,STX17,XPOT,	3.67E-13
GO:0070727	cellular macromolecule localization	JUN,STX7,STX16,TIMM10,NUP98,SEC23A,NAPG,TIMM17A,XPO7,BCL6,SRPR,STAU1,PTPRK,SEC63,BAX,ARCN1,AP2A1,MGEA5,TIMM9,MTX3,NFKBIA,IPO9,MAPK1,LONP2,C16orf70,TOM1,XPO1,EGFR,NEDD4,KPNA4,CTNNB1,SEC24B,PPP1R10,NXT1,SNX2,PCNA,AP2S1,AP3S1,SEC24A,TOMM5,KPNA1,TNKS2,TP53,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,SDCBP,YWHAZ,SEC62,YWHAE,STX17,	4.05E-9
GO:0045184	establishment of protein localization	JUN,RAB18,STX7,RAB34,STX16,ARF6,TIMM10,TMED2,YKT6,NUP98,SEC23A,RHOB,NAPG,SENP2,TIMM17A,XPO7,BCL6,USE1,SRPR,SEC63,ARCN1,PLDN,ARF1,SNX3,ARF3,AP2A1,GDI2,RAB27B,MGEA5,TIMM9,MTX3,NFKBIA,IPO9,MAPK1,TMED10,TNPO3,LONP2,C16orf70,XPO1,TOM1,NEDD4,CANX,RAB21,KPNA4,RAB14,SEC24B,POM121,PPP1R10,NXT1,TMED3,GABARAPL2,SNX2,PCNA,AP2S1,AP3S1,ZDHHC17,SEC24A,TOMM5,ITGA2,ZFYVE20,EXOC2,KPNA1,ARFGAP1,RAB35,TP53,MCFD2,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,RAB22A,VPS13B,SDCBP,CHMP4C,YWHAZ,SEC62,YWHAE,CADPS2,STX17,	5.60E-9
GO:0016071	mRNA metabolic process	EIF2C2,SNRNP40,HNRNPA1L2,RBFOX1,CPSF4,PRPF19,FRG1,PRMT7,RNPS1,HNRNPU,HNRNPK,TRA2A,MBNL1,CPSF1,SNRNP200,HSPA1B,NONO,PNN,MLH1,HSPA1A,EIF2C1,RBFOX2,SF3B3,SRSF9,HNRNPH1,HNRNPC,SCAF1,DHX8,HNRNPA2B1,SMN2,RBM14,SMN1,PABPC1,CPSF7,LSM1,CPSF3,HNRNPA1,PRPF40A,HNRNPM,PRPF4B,RBM5,PTBP3,TRA2B,MTPAP,SERBP1,PTBP1,EXOSC10,RSRC1,PAIP1,POLR2B,POLR2C,	5.73E-9

GO:0015031	protein transport	JUN,RAB18,STX7,RAB34,STX16,ARF6,TIMM10,TMED2,YKT6,NUP98,SEC23A,RHOB,NAPG,SENP2,TIMM17A,XPO7,BCL6,USE1,SRPR,SEC63,ARCN1,PLDN,ARF1,SNX3,ARF3,AP2A1,GDI2,RAB27B,MGEA5,TIMM9,MTX3,NFKBIA,IPO9,MAPK1,TMED10,TNPO3,LONP2,C16orf70,XPO1,TOM1,NEDD4,CANX,RAB21,KPNA4,RAB14,SEC24B,POM121,PPP1R10,NXT1,TMED3,GABARAPL2,SNX2,PCNA,AP2S1,AP3S1,ZDHHC17,SEC24A,TOMM5,ZFYVE20,EXOC2,KPNA1,ARFGAP1,RAB35,TP53,MCFD2,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,RAB22A,VPS13B,SDCBP,CHMP4C,YWHAZ,SEC62,YWHAE,CADPS2,STX17,	8.20E-9
GO:0034613	cellular protein localization	JUN,STX7,STX16,TIMM10,NUP98,SEC23A,NAPG,TIMM17A,XPO7,BCL6,SRPR,PTPRK,SEC63,BAX,ARCN1,AP2A1,MGEA5,TIMM9,MTX3,NFKBIA,IPO9,MAPK1,LONP2,C16orf70,TOM1,XPO1,EGFR,NEDD4,KPNA4,CTNNB1,SEC24B,PPP1R10,NXT1,SNX2,PCNA,AP2S1,AP3S1,SEC24A,TOMM5,KPNA1,TNKS2,TP53,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,SDCBP,YWHAZ,SEC62,YWHAE,STX17,	8.68E-9
GO:0008104	protein localization	JUN,RAB18,RAB34,STX7,STX16,ARF6,TIMM10,TMED2,YKT6,NUP98,SEC23A,RHOB,NAPG,SENP2,TIMM17A,XPO7,BCL6,USE1,SRPR,PTPRK,SEC63,BAX,ARCN1,PLDN,ARF1,MXI1,SNX3,ARF3,GDI2,AP2A1,RAB27B,MGEA5,TIMM9,MTX3,NFKBIA,IPO9,MAPK1,TMED10,TNPO3,LONP2,C16orf70,XPO1,TOM1,EGFR,NEDD4,CBY1,CANX,RAB21,KPNA4,RAB14,SEC24B,CTNNB1,POM121,PPP1R10,NXT1,TMED3,GABARAPL2,SNX2,PCNA,AP2S1,AP3S1,ZDHHC17,SEC24A,TOMM5,ITGA2,ZFYVE20,EXOC2,KPNA1,ARFGAP1,TNKS2,RAB35,TP53,MCFD2,PPP3CA,TIMM8A,DERL1,MACF1,GRPEL2,RAB22A,VPS13B,SDCBP,CHMP4C,YWHAZ,SEC62,YWHAE,CADPS2,STX17,	1.36E-8
GO:0006397	mRNA processing	CPSF7,EIF2C2,LSM1,HNRNPA1L2,SNRNP40,RBFOX1,CPSF4,CPSF3,PRPF19,FRG1,PRMT7,RNPS1,HNRNPA1,HNRNPU,HNRNPK,PRPF40A,TRA2A,MBNL1,CPSF1,SNRNP200,RBM5,HNRNPM,PRPF4B,TRA2B,PTBP3,NONO,PNN,MLH1,MTPAP,RBFOX2,SF3B3,SRSF9,PTBP1,HNRNPH1,HNRNPC,SCAF1,RSRC1,POLR2B,DHX8,POLR2C,HNRNPA2B1,RBM14,SMN2,SMN1,PABPC1,	1.39E-8
GO:0008380	RNA splicing	CPSF7,LSM1,HNRNPA1L2,SNRNP40,ZNF638,RBFOX1,CPSF3,PRPF19,FRG1,PRMT7,RNPS1,HNRNPA1,HNRNPU,HNRNPK,PRPF40A,TRA2A,MBNL1,CPSF1,SNRNP200,RBM5,HNRNPM,PRPF4B,TRA2B,NONO,PNN,RBFOX2,SF3B3,SRSF9,PTBP1,HNRNPH1,HNRNPC,SCAF1,RSRC1,POLR2B,DHX8,POLR2C,HNRNPA2B1,RBM14,SMN2,SMN1,PABPC1,	3.37E-8
GO:0006886	intracellular protein transport	JUN,LONP2,TOM1,XPO1,C16orf70,STX7,STX16,NEDD4,TIMM10,KPNA4,SEC24B,NUP98,PPP1R10,SEC23A,NXT1,NAPG,SNX2,TIMM17A,XPO7,PCNA,AP2S1,BCL6,AP3S1,SEC24A,SRPR,TOMM5,KPNA1,SEC63,ARCN1,TP53,PPP3CA,TIMM8A,MACF1,DERL1,GRPEL2,SDCBP,AP2A1,YWHAZ,MGEA5,SEC62,TIMM9,YWHAE,MTX3,NFKBIA,STX17,IPO9,MAPK1,	6.21E-8
GO:0070271	protein complex biogenesis	SEPT7,MED13,TUBA1A,VAMP3,CAT,JUP,NUP98,IGF1R,TUBB4B,TUBB3,NAPG,SKIL,MAZ,XPO7,HPRT1,SOD2,MLH1,MAP2K1,BAX,SLC9A3R2,SF3B3,HSPA4,TUBA1B,ATL2,SLC7A6,CD2AP,RAC1,SMAD1,CDH2,IPO9,XPO1,CAPZA1,NCOA6,NACC2,RRM2,TAPBP,NDUFAF1,DAG1,CTNNB1,PICALM,HSP90AA1,MKI67IP,AP2S1,GTF3C4,HMGA1,E2F3,TP53,MED1,GTF2H2,GTF2H1,ALDH5A1,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,CDH1,	2.04E-7
GO:0006461	protein complex assembly	SEPT7,MED13,TUBA1A,VAMP3,CAT,JUP,NUP98,IGF1R,TUBB4B,TUBB3,NAPG,SKIL,MAZ,XPO7,HPRT1,SOD2,MLH1,MAP2K1,BAX,SLC9A3R2,SF3B3,HSPA4,TUBA1B,ATL2,SLC7A6,CD2AP,RAC1,SMAD1,CDH2,IPO9,XPO1,CAPZA1,NCOA6,NACC2,RRM2,TAPBP,NDUFAF1,DAG1,CTNNB1,PICALM,HSP90AA1,MKI67IP,AP2S1,GTF3C4,HMGA1,E2F3,TP53,MED1,GTF2H2,GTF2H1,ALDH5A1,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,CDH1,	2.04E-7
GO:0065003	macromolecular complex assembly	SEPT7,MED13,TUBA1A,EIF2A,VAMP3,CAT,JUP,BMS1,TUBB4B,IGF1R,NUP98,TUBB3,PRMT7,NAPG,SKIL,MAZ,XPO7,MBNL1,SNRNP200,HPRT1,SOD2,MLH1,MAP2K1,BAX,SLC9A3R2,SF3B3,HSPA4,TUBA1B,SRSF9,ATL2,SLC7A6,CD2AP,SMN2,SMN1,RAC1,IPO9,SMAD1,CDH2,XPO1,CAPZA1,NCOA6,NACC2,RRM2,TAPBP,NDUFAF1,DAG1,CTNNB1,PICALM,HSP90AA1,MKI67IP,AP2S1,GTF3C4,RBM5,NAP1L1,NIP7,HMGA1,E2F3,TP53,MED1,GTF2H2,ALDH5A1,GTF2H1,HIST1H1A,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,CDH1,	3.94E-7
GO:0016044	membrane organization	RAB18,TOM1,EGFR,STX7,RAB34,KCNN4,KRAS,VAMP3,SUN2,NEDD4,TIMM10,PDLIM7,SEC24B,PICALM,LDLR,NDEL1,SEC23A,HSP90AA1,NAPG,SNX2,LRP8,AP2S1,CNO,SEC24A,GAPVD1,BCL2,BCL2L1,SH3GL1,ARFGAP1,BAX,ARCN1,HSPA4,TP53,TIMM8A,PLDN,GTF2H2,RAB22A,ELMOD2,ARF1,SNX3,AP2A1,GTF2H2C,TIMM9,CORO1C,RAC1,THBS1,	7.19E-7
GO:0006605	protein targeting	JUN,LONP2,XPO1,NEDD4,TIMM10,KPNA4,NUP98,PPP1R10,NXT1,TIMM17A,XPO7,BCL6,SRPR,TOMM5,KPNA1,SEC63,TP53,PPP3CA,TIMM8A,MACF1,GRPEL2,SDCBP,YWHAZ,SEC62,MGEA5,TIMM9,YWHAE,MTX3,NFKBIA,IPO9,MAPK1,	9.28E-7
GO:0043933	macromolecular complex subunit organization	ABI2,SEPT7,MED13,TUBA1A,EIF2A,VAMP3,CAT,JUP,BMS1,TUBB4B,IGF1R,NUP98,TUBB3,PRMT7,NAPG,SKIL,MAZ,XPO7,MBNL1,SNRNP200,HPRT1,SOD2,MLH1,MAP2K1,BAX,SLC9A3R2,SF3B3,HSPA4,TUBA1B,SRSF9,ATL2,SLC7A6,CD2AP,SMN2,SMN1,RAC1,IPO9,CDH2,SMAD1,SMARCE1,XPO1,CAPZA1,NCOA6,NACC2,RRM2,TAPBP,NDUFAF1,DAG1,CTNNB1,PICALM,HSP90AA1,MKI67IP,AP2S1,GTF3C4,RBM5,NAP1L1,NIP7,HMGA1,TP53,E2F3,MED1,GTF2H2,ALDH5A1,GTF2H1,HIST1H1A,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,CDH1,	9.59E-7
GO:0016192	vesicle-mediated transport	RAB18,STX7,RAB34,STX16,VAMP3,ARF6,TMED2,YKT6,SEC23A,RHOB,NAPG,LRP8,ZFPL1,CNO,USE1,SH3GL1,ARCN1,PLDN,ATL2,ARF1,SNX3,ARF3,AP2A1,CORO1C,RAC1,MARCKSL1,TMED10,C16orf70,TOM1,KRAS,TAPBP,PLIN3,NEDD4,RAB14,PDLIM7,SEC24B,CTNNB1,PICALM,LDLR,SCYL1,GABARAPL2,SNX2,HMGXB4,AP2S1,AP3S1,SEC24A,GAPVD1,ZFYVE20,EXOC2,ARFGAP1,RAB35,MCFD2,GTF2H2,ELMOD2,RAB22A,YWHAZ,GTF2H2C,CADPS2,STX17,THBS1,	1.29E-6
GO:0000398	nuclear mRNA splicing, via spliceosome	CPSF7,SNRNP40,CPSF3,RNPS1,PRMT7,HNRNPA1,HNRNPU,HNRNPK,TRA2A,MBNL1,CPSF1,SNRNP200,HNRNPM,RBM5,TRA2B,SF3B3,SRSF9,PTBP1,HNRNPH1,HNRNPC,RSRC1,POLR2B,HNRNPA2B1,POLR2C,SMN2,SMN1,	1.40E-6
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	CPSF7,SNRNP40,CPSF3,RNPS1,PRMT7,HNRNPA1,HNRNPU,HNRNPK,TRA2A,MBNL1,CPSF1,SNRNP200,HNRNPM,RBM5,TRA2B,SF3B3,SRSF9,PTBP1,HNRNPH1,HNRNPC,RSRC1,POLR2B,HNRNPA2B1,POLR2C,SMN2,SMN1,	1.40E-6
GO:0000375	RNA splicing, via transesterification reactions	CPSF7,SNRNP40,CPSF3,RNPS1,PRMT7,HNRNPA1,HNRNPU,HNRNPK,TRA2A,MBNL1,CPSF1,SNRNP200,HNRNPM,RBM5,TRA2B,SF3B3,SRSF9,PTBP1,HNRNPH1,HNRNPC,RSRC1,POLR2B,HNRNPA2B1,POLR2C,SMN2,SMN1,	1.40E-6
GO:0031047	gene silencing by RNA	SRRT,EIF2C2,DGCR8,TNRC6C,EIF2C1,TNRC6A,DROSHA,ERI1,RBM3,LIN28A,SMAD1,	4.63E-6
GO:0010605	negative regulation of macromolecule metabolic process	JUN,CSDA,EIF2C2,SUZ12,HEY1,SKIL,TRIM28,BCL6,PRDM1,PTPRK,MLH1,BAX,TBL1XR1,EIF2C1,LRRFIP1,RBFOX2,ITGB3,PSMB5,EHMT1,PSMA6,C1D,KLF10,EED,TNRC6A,MGEA5,ANAPC5,KLF4,POU2F1,TIMP3,PHB2,RBM3,SMAD1,SMARCE1,RBBP7,RUNX2,SRRT,IRF2,NACC2,RELA,DROSHA,UBE2I,ERI1,SOCS1,NEDD4,DNMT1,CBY1,HUS1,LIN28A,RPS3,CTNNB1,MTDH,EIF2B4,HIC2,TNRC6C,NDFIP1,GZF1,EIF2B1,BCL2L1,HDAC4,RPS27A,TP53,PPP2R4,DGCR8,CDC20,HDAC1,PAIP2,YWHAE,THBS1,	6.00E-6
GO:0033365	protein localization in organelle	JUN,SRPR,TOMM5,KPNA1,XPO1,TP53,KPNA4,TIMM10,PPP3CA,TIMM8A,MACF1,NUP98,PPP1R10,GRPEL2,YWHAZ,TIMM17A,TIMM9,XPO7,MTX3,NFKBIA,BCL6,IPO9,MAPK1,	7.48E-6
GO:0022613	ribonucleoprotein complex biogenesis	DROSHA,EIF2A,ERI1,PES1,BMS1,FRG1,PRMT7,UTP6,EXOSC2,DIS3,MBNL1,UTP15,SNRNP200,RBM5,WDR12,RPS17,NIP7,UTP11L,SRSF9,RPLP0,NOP14,EXOSC10,C1D,RPS7,FTSJ1,SMN2,SMN1,	8.07E-6
GO:0006839	mitochondrial transport	TOMM5,BCL2,BCL2L1,BAX,SLC25A12,TP53,TIMM10,TIMM8A,GRPEL2,HSP90AA1,YWHAZ,ATP5O,TIMM17A,TIMM9,MTX3,	1.12E-5
GO:0035195	gene silencing by miRNA	SRRT,EIF2C2,DGCR8,EIF2C1,TNRC6A,RBM3,LIN28A,SMAD1,	1.31E-5
GO:0044265	cellular macromolecule catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,RNPS1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,HSPA1B,HSPA1A,MLH1,EIF2C1,TBL1XR1,BAX,PSMB5,UFM1,CASP3,PSMA6,ABCE1,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,RELA,USP53,STUB1,DROSHA,UBE2I,SOCS1,UBE2H,NEDD4,USP37,LIN28A,LDLR,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,GTF2H2,GTF2H1,DERL1,EXOSC10,PPP2R5C,UBE2D2,CDC20,MAP1LC3B2,GTF2H2C,USP16,OTUD7A,AIFM1,	1.54E-5
GO:0048193	Golgi vesicle transport	TMED10,USE1,C16orf70,STX7,ARFGAP1,STX16,TAPBP,ARCN1,RAB14,SEC24B,ATL2,YKT6,PLDN,SEC23A,ARF1,SCYL1,NAPG,AP2A1,GABARAPL2,CNO,SEC24A,	1.58E-5
GO:0017038	protein import	JUN,TOMM5,KPNA1,XPO1,TP53,KPNA4,TIMM10,PPP3CA,TIMM8A,NUP98,PPP1R10,GRPEL2,YWHAZ,TIMM17A,TIMM9,XPO7,MTX3,NFKBIA,BCL6,IPO9,MAPK1,	1.58E-5
GO:0034470	ncRNA processing	SRRT,EIF2C2,INTS6,SARS,ERI1,RPP40,PES1,LIN28A,RPP14,FRG1,CPSF3L,UTP6,EXOSC2,DIS3,URM1,UTP15,WDR12,RPS17,UTP11L,NOP14,EXOSC10,C1D,RPS7,DGCR8,FTSJ1,SMAD1,	1.58E-5
GO:0042254	ribosome biogenesis	UTP15,WDR12,EIF2A,DROSHA,RPS17,NIP7,ERI1,UTP11L,PES1,RPLP0,NOP14,BMS1,EXOSC10,C1D,RPS7,FRG1,UTP6,FTSJ1,EXOSC2,DIS3,	1.92E-5
GO:0009057	macromolecule catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,RNPS1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,USE1,HSPA1B,HSPA1A,MLH1,EIF2C1,TBL1XR1,BAX,PSMB5,UFM1,CASP3,PSMA6,ABCE1,ZYG11A,CUL2,MGEA5,ANAPC5,CD2AP,HECTD1,USP5,RELA,MAN2B1,USP53,STUB1,DROSHA,UBE2I,SOCS1,UBE2H,NEDD4,USP37,LIN28A,LDLR,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,GTF2H2,GTF2H1,DERL1,EXOSC10,PPP2R5C,UBE2D2,CDC20,MAP1LC3B2,GTF2H2C,USP16,OTUD7A,AIFM1,	2.46E-5
GO:0016072	rRNA metabolic process	UTP15,WDR12,DROSHA,RPS17,ERI1,UTP11L,PES1,NOP14,EXOSC10,C1D,RPS7,FRG1,UTP6,FTSJ1,MKI67IP,EXOSC2,DIS3,	3.68E-5
GO:0010033	response to organic substance	JUN,EIF2C2,SHC1,DNAJB1,IGF1R,NEUROD1,ERP44,HPRT1,HSPA1B,HSPH1,DNAJA1,PLA2G4A,HSPA1A,MAP2K1,HSPA4,CASP3,DDOST,KLF10,CYR61,MGEA5,TIMP3,RBM3,RBM14,DNAJB4,NFKBIA,SMAD1,MAPK1,UQCRC1,LONP2,SRRT,NCOA6,EGFR,EP300,RELA,CTSC,KRAS,GNG5,SOCS1,CD44,DNAJC3,LIN28A,PPP2R2A,CTNNB1,LDLR,HSP90AA1,GNG2,EIF2B4,IDH1,SOCS3,MAP1B,AP3S1,ITGA2,BCL2,EIF2B1,BCL2L1,HDAC4,PPP3CA,MCL1,DERL1,DGCR8,MAT2A,ACP2,PARP1,THBS1,CDH1,	4.47E-5
GO:0010608	posttranscriptional regulation of gene expression	GATC,SRRT,EIF2C2,EIF1,SOX4,EIF2A,LIN28A,NAPG,EIF2B4,TNRC6C,HNRNPU,ITGA2,BCL2,EIF2B1,SERBP1,EIF2C1,KRT7,DGCR8,PAIP1,TNRC6A,PAIP2,RBM3,RPS4X,THBS1,SMAD1,PABPC1,MAPK1,	4.54E-5
GO:0001836	release of cytochrome c from mitochondria	JUN,BCL2,SOD2,BCL2L1,BAX,GGCT,CASP3,TP53,	6.54E-5
GO:0035194	posttranscriptional gene silencing by RNA	SRRT,EIF2C2,DGCR8,EIF2C1,TNRC6A,RBM3,LIN28A,SMAD1,	6.54E-5
GO:0016441	posttranscriptional gene silencing	SRRT,EIF2C2,DGCR8,EIF2C1,TNRC6A,RBM3,LIN28A,SMAD1,	6.54E-5
GO:0034660	ncRNA metabolic process	CARS2,DARS2,INTS6,SARS,DROSHA,ERI1,RPP40,PES1,LIN28A,RPP14,FRG1,CPSF3L,UTP6,MKI67IP,RARS2,EXOSC2,DIS3,URM1,UTP15,WDR12,RPS17,UTP11L,CARS,NOP14,EXOSC10,C1D,RPS7,FTSJ1,	7.62E-5
GO:0010629	negative regulation of gene expression	RUNX2,CSDA,SRRT,IRF2,EIF2C2,SUZ12,NACC2,DROSHA,HEY1,ERI1,UBE2I,NEDD4,DNMT1,CBY1,LIN28A,CTNNB1,MTDH,TNRC6C,HIC2,SKIL,TRIM28,BCL6,NDFIP1,GZF1,PRDM1,PTPRK,BCL2L1,BAX,EIF2C1,TBL1XR1,LRRFIP1,RBFOX2,HDAC4,TP53,EHMT1,C1D,KLF10,EED,DGCR8,TNRC6A,HDAC1,KLF4,POU2F1,RBM3,PHB2,SMARCE1,SMAD1,RBBP7,	9.18E-5
GO:0007006	mitochondrial membrane organization	TIMM8A,BCL2,BCL2L1,HSP90AA1,BAX,TIMM9,HSPA4,TIMM10,TP53,	1.90E-4
GO:0009411	response to UV	PTPRK,BCL2,EGFR,BAX,RELA,NEDD4,CAT,TP53,CASP3,HUS1,GTF2H2,TUBB3,GTF2H2C,	2.16E-4
GO:0043331	response to dsRNA	SRRT,EIF2C2,DGCR8,RBM3,NFKBIA,LIN28A,SMAD1,MAPK1,	2.24E-4
GO:0035196	gene silencing by miRNA, production of miRNAs	SRRT,EIF2C2,DGCR8,RBM3,LIN28A,SMAD1,	2.29E-4
GO:0006612	protein targeting to membrane	TIMM8A,SRPR,MACF1,SDCBP,SEC63,MGEA5,SEC62,TIMM9,TIMM10,	2.40E-4
GO:0019941	modification-dependent protein catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,TBL1XR1,PSMB5,UFM1,PSMA6,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,STUB1,USP53,UBE2I,UBE2H,NEDD4,SOCS1,USP37,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,DERL1,UBE2D2,PPP2R5C,CDC20,MAP1LC3B2,USP16,OTUD7A,	2.94E-4
GO:0043632	modification-dependent macromolecule catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,TBL1XR1,PSMB5,UFM1,PSMA6,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,STUB1,USP53,UBE2I,UBE2H,NEDD4,SOCS1,USP37,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,DERL1,UBE2D2,PPP2R5C,CDC20,MAP1LC3B2,USP16,OTUD7A,	2.94E-4
GO:0006364	rRNA processing	UTP15,WDR12,RPS17,ERI1,UTP11L,PES1,NOP14,EXOSC10,RPS7,C1D,FRG1,UTP6,FTSJ1,EXOSC2,DIS3,	3.00E-4
GO:0007005	mitochondrion organization	JUN,TOMM5,BCL2,SOD2,BCL2L1,BAX,HSPA4,TP53,TIMM10,CASP3,TIMM8A,GRPEL2,HSP90AA1,GGCT,YWHAZ,TIMM17A,TIMM9,MTX3,POLRMT,	3.24E-4
GO:0031050	dsRNA fragmentation	SRRT,EIF2C2,DGCR8,RBM3,LIN28A,SMAD1,	3.57E-4
GO:0006259	DNA metabolic process	NCOA6,CSNK1E,PRIM1,RRM2,PPIA,DNMT1,HUS1,NUP98,PRPF19,PRMT7,RAD23B,LIN9,NT5E,PCNA,DDB1,DTL,PTMS,MRE11A,NONO,SOD2,EYA3,MLH1,NAP1L1,BAX,ABL1,HMGA1,KRT7,SHFM1,LIG3,CASP3,TP53,MED1,GTF2H2,GTF2H1,CCNE2,POLQ,RBMS1,BCCIP,ATRX,NOL8,GTF2H2C,RBM14,AIFM1,PARP1,DNAJC2,EXO1,RBBP7,	3.70E-4
GO:0006511	ubiquitin-dependent protein catabolic process	USP5,USP53,STUB1,UBE2I,NEDD4,UBE2H,UHRF2,USP37,ERLIN1,RAD23B,SIAH2,DDB1,UBXN1,TBL1XR1,UBE2NL,PSMB5,ERLIN2,RPS27A,PSMA6,DERL1,CUL2,PPP2R5C,UBE2D2,CDC20,CD2AP,ANAPC5,USP16,	4.22E-4
GO:0051603	proteolysis involved in cellular protein catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,TBL1XR1,PSMB5,UFM1,PSMA6,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,RELA,STUB1,USP53,UBE2I,UBE2H,NEDD4,SOCS1,USP37,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,DERL1,UBE2D2,PPP2R5C,CDC20,MAP1LC3B2,USP16,OTUD7A,	4.54E-4
GO:0051789	response to protein stimulus	HSPA1B,ITGA2,HSPH1,BCL2,DNAJA1,BCL2L1,HSPA1A,DNAJB1,DNAJC3,HSPA4,DERL1,KLF10,CYR61,HSP90AA1,DNAJB4,MAP1B,ERP44,	4.61E-4
GO:0044257	cellular protein catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,TBL1XR1,PSMB5,UFM1,PSMA6,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,RELA,STUB1,USP53,UBE2I,UBE2H,NEDD4,SOCS1,USP37,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,DERL1,UBE2D2,PPP2R5C,CDC20,MAP1LC3B2,USP16,OTUD7A,	5.10E-4
GO:0034644	cellular response to UV	PTPRK,BAX,NEDD4,TP53,	5.55E-4
GO:0030163	protein catabolic process	SENP3,MAP1LC3B,YOD1,UHRF2,ATG12,KLHL15,ERLIN1,SENP2,MARCH5,UBE2O,RAD23B,UBE3C,USE1,TBL1XR1,PSMB5,UFM1,PSMA6,ZYG11A,CUL2,ANAPC5,CD2AP,HECTD1,USP5,RELA,STUB1,USP53,UBE2I,SOCS1,UBE2H,NEDD4,USP37,TRIP12,SOCS3,SIAH2,URM1,DDB1,DTL,FEM1B,HERC4,UBXN1,RNF34,UBE2NL,ERLIN2,RPS27A,FBXO3,HUWE1,DERL1,UBE2D2,PPP2R5C,CDC20,MAP1LC3B2,USP16,OTUD7A,	5.89E-4
GO:0016458	gene silencing	SRRT,EIF2C2,DGCR8,TNRC6C,EIF2C1,TNRC6A,DROSHA,ERI1,RBM3,LIN28A,SMAD1,	5.96E-4
GO:0051170	nuclear import	JUN,XPO1,KPNA1,TP53,KPNA4,PPP3CA,NUP98,PPP1R10,HNRNPA1,XPO7,NFKBIA,BCL6,IPO9,MAPK1,	6.54E-4
GO:0051248	negative regulation of protein metabolic process	JUN,EIF2B1,EIF2C2,EIF2C1,BAX,RELA,ITGB3,PSMB5,SOCS1,DNMT1,RPS27A,PSMA6,PPP2R4,EIF2B4,TNRC6A,CDC20,PAIP2,ANAPC5,MGEA5,TIMP3,YWHAE,THBS1,	8.34E-4
GO:0008637	apoptotic mitochondrial changes	JUN,BCL2,SOD2,BCL2L1,BAX,GGCT,CASP3,TP53,	9.34E-4
GO:0006260	DNA replication	MRE11A,NCOA6,NAP1L1,PRIM1,RRM2,HMGA1,KRT7,HUS1,LIG3,MED1,NUP98,CCNE2,POLQ,RBMS1,NOL8,LIN9,PCNA,RBM14,DNAJC2,RBBP7,PTMS,DTL,	1.02E-2
GO:0032268	regulation of cellular protein metabolic process	JUN,GATC,CSF1,EIF2C2,EIF1,EGFR,EP300,STUB1,EIF2A,SOCS1,DNMT1,DLC1,EIF2B4,TNRC6C,SOCS3,DOCK7,NDFIP1,FEM1B,ITGA2,BCL2,EIF2B1,BAX,EIF2C1,HDAC4,ITGB3,PSMB5,KRT7,RPS27A,PSMA6,PPP2R4,PAIP1,TNRC6A,CDC20,PAIP2,ANAPC5,MGEA5,TIMP3,RPS4X,YWHAE,NFKBIA,THBS1,MAPK1,	1.15E-2
GO:0032269	negative regulation of cellular protein metabolic process	JUN,EIF2B1,EIF2C2,EIF2C1,BAX,ITGB3,PSMB5,SOCS1,DNMT1,RPS27A,PSMA6,PPP2R4,EIF2B4,TNRC6A,CDC20,PAIP2,ANAPC5,MGEA5,TIMP3,YWHAE,THBS1,	1.25E-2
GO:0006412	translation	DARS2,CARS2,EIF2C2,SARS,MRPS16,EEF2,EGFR,EIF1,RPL32,EIF2A,RPS12,EEF1A1,RPS3,PTRH1,MRPS5,EIF2B4,RARS2,RPL39,EIF2B1,EIF2S3,RPS17,CARS,RPL27A,RPS27A,RPLP0,RPS8,RPS7,MRPL28,PAIP1,EFTUD1,RPS4X,RBM3,	1.30E-2
GO:0006913	nucleocytoplasmic transport	JUN,MYBBP1A,KPNA1,XPO1,THOC5,TP53,KPNA4,PPP3CA,NUP98,PPP1R10,NXT1,HNRNPA1,RSRC1,XPO7,NFKBIA,BCL6,XPOT,IPO9,MAPK1,	1.40E-2
GO:0051169	nuclear transport	JUN,MYBBP1A,KPNA1,XPO1,THOC5,TP53,KPNA4,PPP3CA,NUP98,PPP1R10,NXT1,HNRNPA1,RSRC1,XPO7,NFKBIA,BCL6,XPOT,IPO9,MAPK1,	1.62E-2
GO:0006626	protein targeting to mitochondrion	TIMM8A,TOMM5,GRPEL2,YWHAZ,TIMM17A,TIMM9,MTX3,TIMM10,	1.66E-2
GO:0070585	protein localization in mitochondrion	TIMM8A,TOMM5,GRPEL2,YWHAZ,TIMM17A,TIMM9,MTX3,TIMM10,	1.66E-2
GO:0006606	protein import into nucleus	JUN,XPO1,KPNA1,TP53,KPNA4,PPP3CA,NUP98,PPP1R10,XPO7,BCL6,NFKBIA,IPO9,MAPK1,	1.73E-2
GO:0009628	response to abiotic stimulus	JUN,CSDA,SLC12A2,EGFR,RELA,KRAS,NEDD4,CAT,HUS1,TUBB3,EIF2B4,CIRBP,SOCS3,MAP1B,PTPRK,ITGA2,BCL2,EIF2B1,SOD2,BCL2L1,NR2F6,PLA2G4A,EYA3,BAX,HSPA4,CASP3,TP53,GTF2H2,MAT2A,GTF2H2C,TIMP3,RBM3,DNAJB4,RAC1,THBS1,	1.90E-2
GO:0033554	cellular response to stress	JUN,NCOA6,ARHGEF6,CSNK1E,BECN1,NEDD4,CAT,HUS1,WNT5A,RPS3,ATG12,PRPF19,EIF2B4,RAD23B,PCNA,MAP1B,BCL6,DDB1,DTL,PTPRK,MRE11A,BCL2,EIF2B1,NONO,SOD2,EYA3,MLH1,BAX,ABL1,SHFM1,LIG3,CASP3,TP53,GTF2H2,DERL1,GTF2H1,POLQ,BCCIP,ATRX,TNRC6A,GTF2H2C,BAZ1B,RBM14,AIFM1,THBS1,PARP1,MAPK1,EXO1,	2.11E-2
GO:0006403	RNA localization	STAU1,XPO1,THOC5,HNRNPA1L2,FMR1,RBFOX1,POM121,NUP98,NXT1,HNRNPA1,SENP2,HNRNPA2B1,XPO7,XPOT,	2.17E-2
GO:0040029	regulation of gene expression, epigenetic	SRRT,EIF2C2,PRMT7,DGCR8,ATRX,EIF2C1,TNRC6A,RBM3,HMGA1,DNMT1,LIN28A,SMAD1,	2.19E-2
GO:0043068	positive regulation of programmed cell death	JUN,SOX4,ARHGEF6,NOTCH1,CD44,DLC1,POU4F1,RPS3,PPP3R1,TUBB4B,MARK4,TNFRSF10B,BCL6,FEM1B,ECT2,RBM5,BCL2,BCL2L1,PLA2G4A,MLH1,BAX,ARHGEF12,ABL1,UTP11L,CASP3,RPS27A,TP53,KLF10,TGM2,TIAL1,CUL2,ETS1,TIMP3,YWHAE,AIFM1,RAC1,TRIO,MAPK1,	2.43E-2
GO:0051052	regulation of DNA metabolic process	JUN,MRE11A,KPNA1,MLH1,SHC1,EYA3,TNKS2,RPS3,TP53,HUS1,IGF1R,MGEA5,PCNA,BCL6,NDFIP1,	2.57E-2
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	UBXN1,TBL1XR1,STUB1,PSMB5,ERLIN2,RPS27A,PSMA6,DERL1,ERLIN1,PPP2R5C,CDC20,RAD23B,ANAPC5,CD2AP,	2.60E-2
GO:0010498	proteasomal protein catabolic process	UBXN1,TBL1XR1,STUB1,PSMB5,ERLIN2,RPS27A,PSMA6,DERL1,ERLIN1,PPP2R5C,CDC20,RAD23B,ANAPC5,CD2AP,	2.60E-2
GO:0010942	positive regulation of cell death	JUN,SOX4,ARHGEF6,NOTCH1,CD44,DLC1,POU4F1,RPS3,PPP3R1,TUBB4B,MARK4,TNFRSF10B,BCL6,FEM1B,ECT2,RBM5,BCL2,BCL2L1,PLA2G4A,MLH1,BAX,ARHGEF12,ABL1,UTP11L,CASP3,RPS27A,TP53,KLF10,TGM2,TIAL1,CUL2,ETS1,TIMP3,YWHAE,AIFM1,RAC1,TRIO,MAPK1,	2.64E-2
GO:0007010	cytoskeleton organization	ABI2,CAPZA1,SEMA6A,LIMCH1,NEDD9,KRAS,FERMT2,SUN2,ARF6,DLC1,CEP72,PDLIM7,CTNNB1,NDEL1,MARK4,DOCK7,CNP,MAP1B,BCL6,RHOF,PCNT,UXT,BCL2,RND3,RAC3,MLH1,FSCN1,KIF11,ABL1,KRT7,TUBA1B,MACF1,ARPC5,SDCBP,NDE1,RAC1,LIMA1,PFN1,	2.74E-2
GO:0043067	regulation of programmed cell death	JUN,CSDA,SOX4,ARHGEF6,NOTCH1,BIRC5,BECN1,CAT,DLC1,PPP3R1,TUBB4B,IGF1R,NEUROD1,BCL6,ECT2,HSPA1B,SOD2,ANXA1,PLA2G4A,HSPA1A,MLH1,BAX,ARHGEF12,ABL1,CASP3,RASA1,KLF10,TIAL1,CUL2,ETS1,TIMP3,SON,NFKBIA,TRIO,RAC1,MAPK1,EGFR,RELA,KRAS,CD44,POU4F1,RPS3,AVEN,TNFRSF10D,TNFRSF10B,MARK4,SOCS3,FEM1B,RBM5,RTN4,BCL2,BCL2L1,UTP11L,RPS27A,TP53,MCL1,TGM2,YWHAZ,HDAC1,YWHAE,AIFM1,THBS1,CDH1,	2.85E-2
GO:0051640	organelle localization	TMED10,UXT,SEMA6A,MLH1,ARFGAP1,MAP2K1,BIRC5,ARCN1,SUN2,YKT6,NDEL1,ARF1,NDE1,	3.08E-2
GO:0051656	establishment of organelle localization	YKT6,TMED10,UXT,ARF1,MLH1,NDE1,ARFGAP1,MAP2K1,BIRC5,ARCN1,SUN2,	3.08E-2
GO:0051094	positive regulation of developmental process	JUN,RUNX2,CSF1,NOTCH1,RELA,OTP,FNDC3B,DDAH1,PDLIM7,CTNNB1,TGIF2,NDEL1,PRPF19,RHOB,NEUROD1,SOCS3,MAP1B,AGGF1,BCL2,PLA2G4A,HOXA11,BAX,MAP2K1,KLF10,ETS1,THBS1,SMAD1,	3.15E-2
GO:0010941	regulation of cell death	JUN,CSDA,SOX4,ARHGEF6,NOTCH1,BIRC5,BECN1,CAT,DLC1,PPP3R1,TUBB4B,IGF1R,NEUROD1,BCL6,ECT2,HSPA1B,SOD2,ANXA1,PLA2G4A,HSPA1A,MLH1,BAX,ARHGEF12,ABL1,CASP3,RASA1,KLF10,TIAL1,CUL2,ETS1,TIMP3,SON,NFKBIA,TRIO,RAC1,MAPK1,EGFR,RELA,KRAS,CD44,POU4F1,RPS3,AVEN,TNFRSF10D,TNFRSF10B,MARK4,SOCS3,FEM1B,RBM5,RTN4,BCL2,BCL2L1,UTP11L,RPS27A,TP53,MCL1,TGM2,YWHAZ,HDAC1,YWHAE,AIFM1,THBS1,CDH1,	3.20E-2
GO:0045767	regulation of anti-apoptosis	RTN4,BCL2L1,SERBP1,BAX,PRKAA1,SMAD1,PIK3R2,RASA1,	3.25E-2
GO:0010970	microtubule-based transport	MACF1,NDEL1,UXT,NDE1,MAP2K1,KLC2,KIF5B,	3.46E-2
GO:0042981	regulation of apoptosis	JUN,CSDA,SOX4,ARHGEF6,NOTCH1,BIRC5,BECN1,CAT,DLC1,PPP3R1,TUBB4B,IGF1R,NEUROD1,BCL6,ECT2,HSPA1B,SOD2,ANXA1,PLA2G4A,HSPA1A,MLH1,BAX,ARHGEF12,ABL1,CASP3,RASA1,KLF10,TIAL1,CUL2,ETS1,TIMP3,SON,NFKBIA,TRIO,RAC1,MAPK1,EGFR,RELA,KRAS,CD44,POU4F1,RPS3,AVEN,TNFRSF10D,TNFRSF10B,SOCS3,FEM1B,RBM5,RTN4,BCL2,BCL2L1,UTP11L,RPS27A,TP53,MCL1,TGM2,YWHAZ,HDAC1,YWHAE,AIFM1,THBS1,CDH1,	3.61E-2
GO:0043066	negative regulation of apoptosis	CSDA,SOX4,EGFR,NOTCH1,RELA,BIRC5,KRAS,BECN1,CAT,IGF1R,TNFRSF10D,AVEN,NEUROD1,SOCS3,BCL6,HSPA1B,BCL2,SOD2,BCL2L1,ANXA1,HSPA1A,BAX,CASP3,RPS27A,TP53,MCL1,RASA1,TGM2,HDAC1,YWHAZ,NFKBIA,SON,THBS1,	3.68E-2
GO:0034504	protein localization in nucleus	JUN,XPO1,KPNA1,TP53,KPNA4,PPP3CA,NUP98,PPP1R10,XPO7,BCL6,NFKBIA,IPO9,MAPK1,	3.69E-2
GO:0016567	protein ubiquitination	SUZ12,STUB1,UHRF2,UBE2H,NEDD4,RPS27A,FBXO3,HUWE1,PRPF19,UBE2D2,TRIP12,SIAH2,UBE3C,DDB1,HECTD1,	3.83E-2
GO:0043065	positive regulation of apoptosis	JUN,SOX4,ARHGEF6,NOTCH1,CD44,DLC1,POU4F1,RPS3,PPP3R1,TUBB4B,TNFRSF10B,BCL6,FEM1B,ECT2,RBM5,BCL2,BCL2L1,PLA2G4A,MLH1,BAX,ARHGEF12,ABL1,UTP11L,CASP3,RPS27A,TP53,KLF10,TGM2,TIAL1,CUL2,ETS1,TIMP3,YWHAE,AIFM1,RAC1,TRIO,MAPK1,	3.93E-2
GO:0009266	response to temperature stimulus	CSDA,BCL2,EIF2B1,PLA2G4A,NR2F6,EIF2B4,CIRBP,SOCS3,RBM3,DNAJB4,HSPA4,THBS1,	3.99E-2
GO:0016055	Wnt receptor signaling pathway	CSNK1G3,STRN,SOX4,CSNK1G2,TBL1XR1,CSNK1G1,FRZB,CXXC4,WNT5A,CTNNB1,MACF1,CTNND1,SENP2,MARK4,KREMEN1,HMGXB4,	4.21E-2
GO:0070647	protein modification by small protein conjugation or removal	SUZ12,STUB1,UHRF2,UBE2H,NEDD4,RPS27A,FBXO3,HUWE1,PRPF19,SENP2,UBE2D2,TRIP12,TRRAP,SIAH2,USP16,UBE3C,DDB1,HECTD1,	4.47E-2
GO:0043069	negative regulation of programmed cell death	CSDA,SOX4,EGFR,NOTCH1,RELA,BIRC5,KRAS,BECN1,CAT,IGF1R,TNFRSF10D,AVEN,NEUROD1,SOCS3,BCL6,HSPA1B,BCL2,SOD2,BCL2L1,ANXA1,HSPA1A,BAX,CASP3,RPS27A,TP53,MCL1,RASA1,TGM2,HDAC1,YWHAZ,NFKBIA,SON,THBS1,	4.53E-2
GO:0051259	protein oligomerization	SEPT7,HPRT1,SOD2,MAP2K1,NACC2,BAX,RRM2,CAT,JUP,TP53,CTNNB1,ATL2,IGF1R,ALDH5A1,TGM2,SKIL,USP16,CDH2,CDH1,	4.64E-2
GO:0060548	negative regulation of cell death	CSDA,SOX4,EGFR,NOTCH1,RELA,BIRC5,KRAS,BECN1,CAT,IGF1R,TNFRSF10D,AVEN,NEUROD1,SOCS3,BCL6,HSPA1B,BCL2,SOD2,BCL2L1,ANXA1,HSPA1A,BAX,CASP3,RPS27A,TP53,MCL1,RASA1,TGM2,HDAC1,YWHAZ,NFKBIA,SON,THBS1,	4.71E-2
GO:0050658	RNA transport	XPO1,THOC5,HNRNPA1L2,FMR1,RBFOX1,POM121,NUP98,NXT1,HNRNPA1,SENP2,HNRNPA2B1,XPO7,XPOT,	4.77E-2
GO:0050657	nucleic acid transport	XPO1,THOC5,HNRNPA1L2,FMR1,RBFOX1,POM121,NUP98,NXT1,HNRNPA1,SENP2,HNRNPA2B1,XPO7,XPOT,	4.77E-2
GO:0051236	establishment of RNA localization	XPO1,THOC5,HNRNPA1L2,FMR1,RBFOX1,POM121,NUP98,NXT1,HNRNPA1,SENP2,HNRNPA2B1,XPO7,XPOT,	4.77E-2
GO:0006417	regulation of translation	GATC,ITGA2,EIF2C2,EIF2B1,EIF1,EIF2C1,EIF2A,KRT7,EIF2B4,PAIP1,TNRC6C,TNRC6A,PAIP2,RPS4X,THBS1,MAPK1,	5.56E-2
GO:0000302	response to reactive oxygen species	JUN,PTPRK,BCL2,SOD2,BCL2L1,PLA2G4A,EP300,RELA,ND6,CAT,SERPINE1,	5.67E-2
GO:0006916	anti-apoptosis	HSPA1B,BCL2,SOD2,BCL2L1,ANXA1,HSPA1A,BAX,RELA,BIRC5,BECN1,RPS27A,MCL1,IGF1R,TGM2,TNFRSF10D,AVEN,YWHAZ,HDAC1,SOCS3,NFKBIA,SON,THBS1,	6.01E-2
GO:0006518	peptide metabolic process	PAM,ALDH5A1,SEC11A,SOD2,SEC11C,IDH1,TAPBP,HAGH,SPCS3,	6.08E-2
GO:0006901	vesicle coating	PICALM,ARF1,ARFGAP1,ARCN1,AP2S1,	6.48E-2
GO:0006414	translational elongation	RPL39,EEF2,RPL32,RPS17,EEF1A1,RPS12,RPS27A,RPLP0,RPL27A,RPS3,RPS8,RPS7,RPS4X,	6.60E-2
GO:0009890	negative regulation of biosynthetic process	RUNX2,CSDA,IRF2,EIF2C2,SUZ12,NACC2,HEY1,UBE2I,NEDD4,DNMT1,CBY1,HUS1,CTNNB1,MTDH,EIF2B4,HIC2,PRKAA1,SKIL,TRIM28,BCL6,GZF1,PRDM1,PTPRK,EIF2B1,EIF2C1,TBL1XR1,LRRFIP1,RBFOX2,HDAC4,ITGB3,ATP1A1,TP53,EHMT1,C1D,KLF10,EED,TNRC6A,HDAC1,PAIP2,MGEA5,KLF4,POU2F1,PHB2,SMARCE1,RBBP7,	7.27E-2
GO:0006974	response to DNA damage stimulus	NCOA6,CSNK1E,HUS1,RPS3,PRPF19,RAD23B,PCNA,BCL6,DDB1,DTL,MRE11A,SOD2,NONO,MLH1,EYA3,BAX,ABL1,SHFM1,LIG3,CASP3,TP53,GTF2H2,GTF2H1,POLQ,BCCIP,ATRX,GTF2H2C,BAZ1B,RBM14,AIFM1,PARP1,MAPK1,EXO1,	7.80E-2
GO:0034097	response to cytokine stimulus	JUN,DDOST,BCL2,BCL2L1,RELA,HDAC4,SOCS3,SOCS1,CASP3,CTNNB1,MCL1,	8.18E-2
GO:0031327	negative regulation of cellular biosynthetic process	RUNX2,CSDA,IRF2,EIF2C2,SUZ12,NACC2,HEY1,UBE2I,NEDD4,DNMT1,CBY1,HUS1,CTNNB1,MTDH,EIF2B4,PRKAA1,HIC2,SKIL,TRIM28,BCL6,GZF1,PRDM1,PTPRK,EIF2B1,EIF2C1,TBL1XR1,LRRFIP1,RBFOX2,HDAC4,ATP1A1,TP53,EHMT1,C1D,KLF10,EED,TNRC6A,HDAC1,PAIP2,MGEA5,KLF4,POU2F1,PHB2,SMARCE1,RBBP7,	8.21E-2
GO:0006900	membrane budding	PICALM,ARF1,ARFGAP1,ARCN1,AP2S1,	8.29E-2
GO:0042542	response to hydrogen peroxide	JUN,BCL2,SOD2,BCL2L1,PLA2G4A,EP300,RELA,ND6,CAT,	8.50E-2
GO:0031175	neuron projection development	ABI2,HPRT1,STRN,BCL2,RAC3,SEMA6A,EGFR,MAP2K1,NOTCH1,CELSR3,NEDD4,CD44,CHAT,RPS27A,POU4F1,ATXN10,MACF1,IGF1R,NDEL1,DOCK7,CNP,MAP1B,RAC1,CDH1,	8.50E-2
GO:0010558	negative regulation of macromolecule biosynthetic process	RUNX2,CSDA,IRF2,EIF2C2,SUZ12,NACC2,HEY1,UBE2I,NEDD4,DNMT1,CBY1,HUS1,CTNNB1,MTDH,EIF2B4,HIC2,SKIL,TRIM28,BCL6,GZF1,PRDM1,PTPRK,EIF2B1,EIF2C1,TBL1XR1,LRRFIP1,RBFOX2,HDAC4,ITGB3,TP53,EHMT1,C1D,KLF10,EED,TNRC6A,HDAC1,PAIP2,MGEA5,KLF4,POU2F1,PHB2,SMARCE1,RBBP7,	8.62E-2
GO:0032446	protein modification by small protein conjugation	SUZ12,STUB1,UHRF2,UBE2H,NEDD4,RPS27A,FBXO3,HUWE1,PRPF19,UBE2D2,TRIP12,SIAH2,UBE3C,DDB1,HECTD1,	9.51E-2
GO:0047496	vesicle transport along microtubule	NDEL1,NDE1,MAP2K1,KIF5B,	9.56E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value