Gene ontology terms enriched for interacted genes |
GO terms | GO terms description | target genes enrich in GO term | p-value |
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GO:0010604
|
positive regulation of macromolecule metabolic process |
YAP1,BCL2,PSMD2,TCF7L1,MAPK14,SHC1,HDAC4,GATA6,CTNNB1,SMAD3,ZFPM2,THBS1,ZEB1,SMAD2, |
5.86E-7 |
GO:0016481
|
negative regulation of transcription |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
6.22E-7 |
GO:0010605
|
negative regulation of macromolecule metabolic process |
PSMD2,TCF7L1,HDAC4,ZEB2,PDCD4,CTNNB1,KLF11,SMAD3,ZFPM2,THBS1,ZEB1,SIRT1,SMAD2, |
8.14E-7 |
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter |
YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
1.02E-6 |
GO:0051094
|
positive regulation of developmental process |
BCL2,MAPK14,SMAD3,DLX5,BAD,GATA6,THBS1,CTNNB1,SMAD2, |
1.25E-6 |
|
GO:0010629
|
negative regulation of gene expression |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
1.45E-6 |
GO:0045934
|
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
1.68E-6 |
GO:0042127
|
regulation of cell proliferation |
BCL2,SHC1,HDAC4,DLX5,CTNNB1,VCAM1,BAP1,KLF11,SMAD3,THBS1,ZEB1,SIRT1,SMAD2, |
1.70E-6 |
GO:0051172
|
negative regulation of nitrogen compound metabolic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
1.90E-6 |
GO:0010557
|
positive regulation of macromolecule biosynthetic process |
YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2, |
1.98E-6 |
GO:0010558
|
negative regulation of macromolecule biosynthetic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
3.04E-6 |
GO:0031328
|
positive regulation of cellular biosynthetic process |
YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2, |
3.11E-6 |
GO:0001501
|
skeletal system development |
BCL2,MAPK14,HOXB5,SMAD3,HDAC4,DLX5,TRAPPC2P1,ZEB1,CTNNB1, |
3.48E-6 |
GO:0009891
|
positive regulation of biosynthetic process |
YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2, |
3.57E-6 |
GO:0031327
|
negative regulation of cellular biosynthetic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
3.81E-6 |
GO:0045597
|
positive regulation of cell differentiation |
BCL2,MAPK14,SMAD3,DLX5,BAD,GATA6,CTNNB1,SMAD2, |
4.21E-6 |
GO:0009890
|
negative regulation of biosynthetic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2, |
4.61E-6 |
GO:0006357
|
regulation of transcription from RNA polymerase II promoter |
YAP1,MAPK14,KLF11,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2, |
5.51E-6 |
GO:0045892
|
negative regulation of transcription, DNA-dependent |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2, |
7.82E-6 |
GO:0045893
|
positive regulation of transcription, DNA-dependent |
YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
8.05E-6 |
GO:0051254
|
positive regulation of RNA metabolic process |
YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
8.62E-6 |
GO:0051253
|
negative regulation of RNA metabolic process |
KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2, |
8.84E-6 |
GO:0045935
|
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
9.79E-6 |
GO:0051173
|
positive regulation of nitrogen compound metabolic process |
YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
1.29E-5 |
GO:0048729
|
tissue morphogenesis |
BCL2,TCF7L1,SMAD3,PCDH8,ZEB2,CTNNB1,SMAD2, |
1.34E-5 |
GO:0048598
|
embryonic morphogenesis |
HOXB5,SMAD3,PCDH8,DLX5,ZEB2,ZEB1,CTNNB1,SMAD2, |
2.83E-5 |
GO:0045941
|
positive regulation of transcription |
YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
3.06E-5 |
GO:0010628
|
positive regulation of gene expression |
YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2, |
3.86E-5 |
GO:0032583
|
regulation of gene-specific transcription |
SMAD3,HDAC4,GATA6,SIRT1,CTNNB1,SMAD2, |
4.40E-5 |
GO:0043009
|
chordate embryonic development |
HOXB5,PCDH8,KEAP1,GATA6,ZFPM2,ZEB2,ZEB1,SMAD2, |
4.58E-5 |
GO:0009792
|
embryonic development ending in birth or egg hatching |
HOXB5,PCDH8,KEAP1,GATA6,ZFPM2,ZEB2,ZEB1,SMAD2, |
4.85E-5 |
GO:0060429
|
epithelium development |
BCL2,HOXB5,PCDH8,DLX5,GATA6,ZEB2,CTNNB1, |
4.97E-5 |
GO:0006915
|
apoptosis |
BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1, |
5.10E-5 |
GO:0009952
|
anterior/posterior pattern formation |
TCF7L1,HOXB5,PCDH8,ZEB2,CTNNB1,SMAD2, |
5.43E-5 |
GO:0012501
|
programmed cell death |
BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1, |
5.72E-5 |
GO:0008285
|
negative regulation of cell proliferation |
BCL2,BAP1,KLF11,SMAD3,HDAC4,ZEB1,THBS1,SMAD2, |
7.93E-5 |
GO:0006355
|
regulation of transcription, DNA-dependent |
YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,DLX5,GATA6,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2, |
8.74E-5 |
GO:0051252
|
regulation of RNA metabolic process |
YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,DLX5,GATA6,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2, |
1.13E-4 |
GO:0007389
|
pattern specification process |
TCF7L1,HOXB5,PCDH8,ZEB2,ZEB1,CTNNB1,SMAD2, |
1.22E-4 |
GO:0043193
|
positive regulation of gene-specific transcription |
SMAD3,HDAC4,GATA6,CTNNB1,SMAD2, |
1.22E-4 |
GO:0010551
|
regulation of specific transcription from RNA polymerase II promoter |
SMAD3,HDAC4,GATA6,SIRT1,CTNNB1, |
1.64E-4 |
GO:0008219
|
cell death |
BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1, |
1.98E-4 |
GO:0017015
|
regulation of transforming growth factor beta receptor signaling pathway |
SMAD3,ZEB1,THBS1,SMAD2, |
2.03E-4 |
GO:0016265
|
death |
BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1, |
2.09E-4 |
GO:0003002
|
regionalization |
TCF7L1,HOXB5,PCDH8,ZEB2,CTNNB1,SMAD2, |
2.70E-4 |
GO:0035295
|
tube development |
BCL2,GATA6,ZFPM2,ZEB2,CTNNB1,SMAD2, |
4.49E-4 |
GO:0045449
|
regulation of transcription |
YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,KEAP1,DLX5,GATA6,ZEB2,PDCD4,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2, |
6.07E-4 |
GO:0010552
|
positive regulation of specific transcription from RNA polymerase II promoter |
SMAD3,HDAC4,GATA6,CTNNB1, |
6.27E-4 |
GO:0000578
|
embryonic axis specification |
TCF7L1,CTNNB1,SMAD2, |
8.73E-4 |
GO:0051098
|
regulation of binding |
BCL2,SMAD3,HDAC4,SIRT1,SMAD2, |
1.04E-2 |
GO:0010033
|
response to organic substance |
BCL2,MAPK14,SHC1,TFRC,SMAD3,HDAC4,THBS1,CTNNB1,SMAD2, |
1.05E-2 |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter |
KLF11,SMAD3,HDAC4,ZFPM2,ZEB1,CTNNB1, |
1.06E-2 |
GO:0030278
|
regulation of ossification |
BCL2,SMAD3,DLX5,CTNNB1, |
1.56E-2 |
GO:0007049
|
cell cycle |
SEPT7,CCNE2,BCL2,ERBB2IP,PSMD2,SMAD3,THBS1,CTNNB1,RASSF2, |
1.68E-2 |
GO:0008633
|
activation of pro-apoptotic gene products |
BCL2,SMAD3,BAD, |
1.89E-2 |
GO:0046649
|
lymphocyte activation |
VCAM1,BCL2,SMAD3,HDAC4,CTNNB1, |
2.74E-2 |
GO:0019220
|
regulation of phosphate metabolic process |
CCNE2,BCL2,SHC1,SMAD3,PDCD4,ZEB2,THBS1, |
2.80E-2 |
GO:0051174
|
regulation of phosphorus metabolic process |
CCNE2,BCL2,SHC1,SMAD3,PDCD4,ZEB2,THBS1, |
2.80E-2 |
GO:0001952
|
regulation of cell-matrix adhesion |
BCL2,SMAD3,THBS1, |
2.85E-2 |
GO:0030324
|
lung development |
GATA6,ZFPM2,CTNNB1,SMAD2, |
3.08E-2 |
GO:0002009
|
morphogenesis of an epithelium |
BCL2,PCDH8,ZEB2,CTNNB1, |
3.26E-2 |
GO:0030323
|
respiratory tube development |
GATA6,ZFPM2,CTNNB1,SMAD2, |
3.35E-2 |
GO:0030098
|
lymphocyte differentiation |
VCAM1,BCL2,HDAC4,CTNNB1, |
3.45E-2 |
GO:0009798
|
axis specification |
TCF7L1,CTNNB1,SMAD2, |
3.51E-2 |
GO:0045596
|
negative regulation of cell differentiation |
SMAD3,HDAC4,SIRT1,ZEB1,CTNNB1, |
3.68E-2 |
GO:0060541
|
respiratory system development |
GATA6,ZFPM2,CTNNB1,SMAD2, |
3.94E-2 |
GO:0009880
|
embryonic pattern specification |
TCF7L1,CTNNB1,SMAD2, |
3.99E-2 |
GO:0007568
|
aging |
BCL2,TFRC,PDCD4,SIRT1, |
4.15E-2 |
GO:0007569
|
cell aging |
BCL2,PDCD4,SIRT1, |
4.24E-2 |
GO:0045321
|
leukocyte activation |
VCAM1,BCL2,SMAD3,HDAC4,CTNNB1, |
5.50E-2 |
GO:0048332
|
mesoderm morphogenesis |
TCF7L1,SMAD3,SMAD2, |
5.60E-2 |
GO:0006350
|
transcription |
TCF7L1,HOXB5,HDAC4,GATA6,KEAP1,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2, |
5.76E-2 |
GO:0051147
|
regulation of muscle cell differentiation |
BCL2,HDAC4,ZEB1, |
5.89E-2 |
GO:0001704
|
formation of primary germ layer |
SMAD3,CTNNB1,SMAD2, |
6.19E-2 |
GO:0010038
|
response to metal ion |
BCL2,TFRC,THBS1,CTNNB1, |
6.47E-2 |
GO:0002521
|
leukocyte differentiation |
VCAM1,BCL2,HDAC4,CTNNB1, |
6.75E-2 |
GO:0044093
|
positive regulation of molecular function |
BCL2,PSMD2,SHC1,SMAD3,HDAC4,ZEB2,THBS1, |
7.04E-2 |
GO:0045667
|
regulation of osteoblast differentiation |
SMAD3,DLX5,CTNNB1, |
7.13E-2 |
GO:0001666
|
response to hypoxia |
BCL2,TFRC,SMAD3,THBS1, |
7.18E-2 |
GO:0042306
|
regulation of protein import into nucleus |
G3BP2,SMAD3,SIRT1, |
7.45E-2 |
GO:0032880
|
regulation of protein localization |
BCL2,G3BP2,SMAD3,SIRT1, |
7.79E-2 |
GO:0010810
|
regulation of cell-substrate adhesion |
BCL2,SMAD3,THBS1, |
8.12E-2 |
GO:0070482
|
response to oxygen levels |
BCL2,TFRC,SMAD3,THBS1, |
8.26E-2 |
GO:0043405
|
regulation of MAP kinase activity |
SHC1,PDCD4,ZEB2,THBS1, |
8.26E-2 |
GO:0030183
|
B cell differentiation |
VCAM1,BCL2,HDAC4, |
8.82E-2 |
GO:0035282
|
segmentation |
TCF7L1,PCDH8,ZEB2, |
8.82E-2 |
GO:0016202
|
regulation of striated muscle tissue development |
BCL2,SMAD3,HDAC4, |
9.54E-2 |
GO:0014031
|
mesenchymal cell development |
BCL2,ZEB2,CTNNB1, |
9.91E-2 |
GO:0048762
|
mesenchymal cell differentiation |
BCL2,ZEB2,CTNNB1, |
9.91E-2 |
GO:0048634
|
regulation of muscle development |
BCL2,SMAD3,HDAC4, |
9.91E-2 |
GO:0001775
|
cell activation |
VCAM1,BCL2,SMAD3,HDAC4,CTNNB1, |
9.94E-2 |
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