MI0000279
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MIPF0000031
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UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
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MIMAT0000226
hsa-miR-196a-5p
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UAGGUAGUUUCAUGUUGUUGGG
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This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
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MI0000279
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MIPF0000031
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UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
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MIMAT0004562
hsa-miR-196a-3p
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CGGCAACAAGAAACUGCCUGAG
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This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
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MI0000279
|
MIPF0000031
|
UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
|
MIMAT0000226
hsa-miR-196a-5p
|
UAGGUAGUUUCAUGUUGUUGGG
|
This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
|
MI0000279
|
MIPF0000031
|
UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
|
MIMAT0004562
hsa-miR-196a-3p
|
CGGCAACAAGAAACUGCCUGAG
|
This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
|
MI0000279
|
MIPF0000031
|
UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
|
MIMAT0000226
hsa-miR-196a-5p
|
UAGGUAGUUUCAUGUUGUUGGG
|
This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
|
MI0000279
|
MIPF0000031
|
UGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGC
|
MIMAT0004562
hsa-miR-196a-3p
|
CGGCAACAAGAAACUGCCUGAG
|
This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. miR-196awas later validated in human [3,4]. Yekta et al. report that miR-196miRNAs are expressed from HOX gene clusters in mammals, and that HOX genesin these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown tobe a natural target for miR-196-directed cleavage through a perfectlycomplementary miR-target site. Other HOX genes have imperfect miR-196complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly clonedform from large-scale cloning studies .
|