Gene ontology terms enriched for interacted genes
GO terms GO terms description target genes enrich in GO term p-value
GO:0045449
regulation of transcription
NOTCH4,E2F1,ZNF25,RLF,MECP2,NR2F1,HMGB2,NOTCH2,ZNF652,ZNF148,HMGB1,NOTCH1,KLF6,TAF2,ZNF350,CDX2,MED14,CAT,SNAI2,RPS14,ANKRD1,SCAP,NR6A1,TGIF2,ZNF426,LMCD1,TBX4,MAZ,PLAG1,ZNF562,NKX3-2,ZNF35,TGFBRAP1,BRCA1,MAP2K1,MAP3K10,UBB,ZNF763,TIAL1,HNRNPAB,ZNF526,PHOX2A,ARHGAP35,ZNF503,ENO1,ARID3B,TRRAP,SIRT1,TEAD4,COPS2,PBX2,ILF2,EP300,EYA4,KRAS,TMEM189,GATA6,ZNF747,SIX6,CDKN1B,ZBTB4,RNF2,RQCD1,HIPK2,OTX2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR3,GATAD2B,TGFBR1,IL2,ATF7IP2,NLK,KAT2B,PROX1,ZNF558,TAF5L,S100A1,ZNF594,HEY2,ZEB2,CBX7,ZFHX3,BRMS1L,NANOG,PRDX3,ZNF445,ZBTB20,ZNF12,XRCC6,BPTF,FOS,
3.02E-9
GO:0016481
negative regulation of transcription
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
2.32E-7
GO:0010557
positive regulation of macromolecule biosynthetic process
TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,
4.95E-7
GO:0051252
regulation of RNA metabolic process
ZNF25,E2F1,NOTCH4,MECP2,HMGB2,NR2F1,NOTCH2,HMGB1,ZNF148,NOTCH1,TAF2,KLF6,ZNF350,CDX2,MED14,SNAI2,RPS14,ANKRD1,NR6A1,SCAP,TGIF2,ZNF426,LMCD1,TBX4,ZNF562,NKX3-2,ZFP36L2,ZNF35,BRCA1,MAP2K1,ZNF763,TIAL1,HNRNPAB,PHOX2A,ENO1,PABPC1,SIRT1,TEAD4,PBX2,ILF2,EP300,TMEM189,GATA6,ZNF747,CDKN1B,SIX6,RNF2,HIPK2,OTX2,TCF21,HDAC6,NFYB,ARID1A,GATAD2B,IL2,KAT2B,PROX1,ZNF558,S100A1,ZEB2,HEY2,ZFHX3,NANOG,ZNF445,ZNF12,XRCC6,FOS,BPTF,
6.12E-7
GO:0009891
positive regulation of biosynthetic process
TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HSP90AB1,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,
6.99E-7
GO:0010604
positive regulation of macromolecule metabolic process
TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,TAF2,KLF6,GATA6,MED14,CDX2,NRD1,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,HDAC6,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BMPR2,BCL2,ATG10,BRCA1,MAP2K1,PROX1,KIT,UBB,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,
7.38E-7
GO:0051173
positive regulation of nitrogen compound metabolic process
TEAD4,HRAS,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,MAP2K1,PROX1,UBB,HSP90AB1,HNRNPAB,XRCC6,BPTF,FOS,
1.02E-6
GO:0006355
regulation of transcription, DNA-dependent
ZNF25,E2F1,NOTCH4,MECP2,HMGB2,NR2F1,NOTCH2,HMGB1,ZNF148,NOTCH1,TAF2,KLF6,ZNF350,MED14,CDX2,SNAI2,RPS14,ANKRD1,NR6A1,SCAP,TGIF2,ZNF426,LMCD1,TBX4,ZNF562,NKX3-2,ZNF35,BRCA1,MAP2K1,ZNF763,TIAL1,HNRNPAB,PHOX2A,ENO1,SIRT1,TEAD4,PBX2,ILF2,EP300,TMEM189,GATA6,ZNF747,CDKN1B,SIX6,RNF2,HIPK2,OTX2,TCF21,HDAC6,NFYB,ARID1A,GATAD2B,IL2,KAT2B,PROX1,ZNF558,S100A1,ZEB2,HEY2,ZFHX3,NANOG,ZNF445,ZNF12,XRCC6,FOS,BPTF,
1.26E-6
GO:0031328
positive regulation of cellular biosynthetic process
TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HSP90AB1,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,
1.40E-6
GO:0045935
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
TEAD4,HRAS,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,MAP2K1,PROX1,UBB,HNRNPAB,XRCC6,BPTF,FOS,
1.48E-6
GO:0010629
negative regulation of gene expression
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
1.50E-6
GO:0006357
regulation of transcription from RNA polymerase II promoter
TEAD4,PBX2,E2F1,HMGB2,NR2F1,MECP2,HMGB1,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SNAI2,RPS14,SCAP,NR6A1,ANKRD1,RNF2,HIPK2,LMCD1,IL2,BRCA1,MAP2K1,PROX1,S100A1,HEY2,ZFHX3,TIAL1,ENO1,XRCC6,BPTF,FOS,SIRT1,
1.94E-6
GO:0045934
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
2.03E-6
GO:0051172
negative regulation of nitrogen compound metabolic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
2.67E-6
GO:0051254
positive regulation of RNA metabolic process
TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ARID1A,IL2,BRCA1,PROX1,MAP2K1,HNRNPAB,XRCC6,BPTF,FOS,
6.03E-6
GO:0009890
negative regulation of biosynthetic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDKN1B,CDX2,RPS14,SNAI2,NR6A1,SCAP,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
6.13E-6
GO:0010558
negative regulation of macromolecule biosynthetic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
7.24E-6
GO:0010628
positive regulation of gene expression
TEAD4,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,KIT,UBB,HNRNPAB,XRCC6,BPTF,FOS,
8.09E-6
GO:0031327
negative regulation of cellular biosynthetic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,
1.14E-5
GO:0035295
tube development
BMPR2,WNT3A,NOTCH4,BCL2,SPRY2,EP300,NOTCH1,PROX1,GATA6,WNT2,ZEB2,NRP1,TCF21,ARHGAP35,TBX4,BCL2L11,TGFBR1,
1.15E-5
GO:0045941
positive regulation of transcription
TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HNRNPAB,XRCC6,BPTF,FOS,
1.28E-5
GO:0045892
negative regulation of transcription, DNA-dependent
E2F1,NR2F1,MECP2,ZNF148,HMGB1,PROX1,CDX2,CDKN1B,RPS14,SNAI2,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,HNRNPAB,TCF21,LMCD1,ENO1,BPTF,SIRT1,
1.33E-5
GO:0043549
regulation of kinase activity
PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
1.39E-5
GO:0045893
positive regulation of transcription, DNA-dependent
TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ARID1A,IL2,BRCA1,PROX1,HNRNPAB,XRCC6,BPTF,FOS,
1.54E-5
GO:0010605
negative regulation of macromolecule metabolic process
COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDKN1B,CDX2,SNAI2,RPS14,NR6A1,RNF2,HIPK2,TCF21,HDAC6,LMCD1,IL2,BRCA1,PROX1,MAP3K10,UBB,HSP90AB1,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,TIMP3,BPTF,SIRT1,
1.63E-5
GO:0051253
negative regulation of RNA metabolic process
E2F1,NR2F1,MECP2,ZNF148,HMGB1,PROX1,CDX2,CDKN1B,RPS14,SNAI2,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,HNRNPAB,TCF21,LMCD1,ENO1,BPTF,SIRT1,
1.71E-5
GO:0006350
transcription
E2F1,ZNF25,NOTCH4,RLF,MECP2,NR2F1,NOTCH2,ZNF652,ZNF148,NOTCH1,KLF6,TAF2,ZNF350,CDX2,MED14,SNAI2,NR6A1,TGIF2,ZNF426,TBX4,MAZ,PLAG1,ZNF562,NKX3-2,ZNF35,ZNF763,ZNF526,PHOX2A,ARHGAP35,ZNF503,ARID3B,ENO1,TRRAP,SIRT1,DIDO1,TEAD4,COPS2,PBX2,ILF2,EP300,EYA4,GATA6,ZBTB4,RNF2,RQCD1,HIPK2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,GATAD2B,ATF7IP2,BMPR2,NLK,KAT2B,PROX1,ZNF558,TAF5L,ZNF594,HEY2,ZEB2,CBX7,ZFHX3,BRMS1L,NANOG,ZNF445,ZBTB20,ZNF12,BPTF,
2.57E-5
GO:0051338
regulation of transferase activity
PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
2.58E-5
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
E2F1,MECP2,NR2F1,ZNF148,HMGB1,PROX1,CDX2,SNAI2,RPS14,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,LMCD1,ENO1,BPTF,
3.30E-5
GO:0006793
phosphorus metabolic process
PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,PTPRZ1,PHPT1,PTPN22,MOB1B,ATP6V0E1,TGFBR3,NRBP1,DUSP5,TGFBR1,DUSP6,MTMR3,BMPR2,PTEN,SRPK2,BCL2,NLK,EPHA5,CHRFAM7A,MAP2K1,MAP3K10,MTMR12,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,
8.16E-5
GO:0006796
phosphate metabolic process
PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,PTPRZ1,PHPT1,PTPN22,MOB1B,ATP6V0E1,TGFBR3,NRBP1,DUSP5,TGFBR1,DUSP6,MTMR3,BMPR2,PTEN,SRPK2,BCL2,NLK,EPHA5,CHRFAM7A,MAP2K1,MAP3K10,MTMR12,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,
8.16E-5
GO:0007568
aging
HRAS,PTEN,BCL2,NOTCH4,PHOX2A,KRAS,FOS,TIMP3,TGFBR1,SIRT1,SCAP,
8.27E-5
GO:0042325
regulation of phosphorylation
BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
8.57E-5
GO:0045859
regulation of protein kinase activity
PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
8.72E-5
GO:0032583
regulation of gene-specific transcription
HMGB2,HNRNPAB,PROX1,NOTCH1,TAF2,XRCC6,GATA6,CDKN1B,BPTF,SIRT1,HEY2,SCAP,
9.33E-5
GO:0006325
chromatin organization
HMGB2,KAT2B,EP300,EYA4,HMGB1,H1F0,TAF5L,H2AFY,HIST1H1E,CBX7,HUWE1,H3F3B,RNF2,HIST1H3D,NPM2,HDAC6,ARID1A,BPTF,TRRAP,HIST2H4B,SIRT1,
9.90E-5
GO:0008284
positive regulation of cell proliferation
HRAS,NOTCH4,BCL2,PTGS2,CHRFAM7A,NOTCH1,PROX1,KIT,KRAS,CDX2,CDKN1B,HEY2,MTOR,FGFR1,TSHR,IGF1R,HIPK2,NRP1,EIF5A,PRDX3,TGFBR1,IL2,
1.19E-4
GO:0043069
negative regulation of programmed cell death
HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KIT,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,
1.46E-4
GO:0043405
regulation of MAP kinase activity
SPRY2,GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,LRRN3,DUSP6,ZEB2,
1.47E-4
GO:0060548
negative regulation of cell death
HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KIT,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,
1.53E-4
GO:0051174
regulation of phosphorus metabolic process
BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
1.55E-4
GO:0019220
regulation of phosphate metabolic process
BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,
1.55E-4
GO:0044087
regulation of cellular component biogenesis
PTEN,RALA,HMGB1,PROX1,HDAC6,KIT,CDKN1B,ARF6,UBB,WNT2,TGFBR1,MTOR,
1.56E-4
GO:0002520
immune system development
BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PTPN22,PRDX3,TGFBR3,XRCC6,BCL2L11,TGFBR1,NKX3-2,IL2,
1.76E-4
GO:0030324
lung development
BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,
1.87E-4
GO:0007243
protein kinase cascade
SRPK2,NOTCH4,NLK,PTPN11,SIK2,PRLR,PTPLAD1,CHRFAM7A,TMED7,MAP2K1,MAP3K10,KIT,FGFR1,IGF1R,GAB1,GADD45G,TGFBR3,TGFBR1,LRRN3,DUSP6,
2.15E-4
GO:0043406
positive regulation of MAP kinase activity
GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,LRRN3,ZEB2,
2.34E-4
GO:0030323
respiratory tube development
BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,
2.34E-4
GO:0009719
response to endogenous stimulus
PTEN,BCL2,HMGB2,PTPN11,SIK2,KAT2B,BRCA1,EP300,PTGS2,MAP2K1,KRAS,WNT2,MTOR,IGF1R,GAB1,HDAC6,ATP6V0E1,TGFBR3,TIMP3,FOS,TGFBR1,
2.47E-4
GO:0033674
positive regulation of kinase activity
PTPN11,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,PFKFB2,TGFBR1,LRRN3,IL2,
2.79E-4
GO:0048534
hemopoietic or lymphoid organ development
BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PTPN22,PRDX3,TGFBR3,BCL2L11,TGFBR1,NKX3-2,IL2,
2.95E-4
GO:0018205
peptidyl-lysine modification
KAT2B,EIF5A,EP300,HDAC6,SIRT1,
3.27E-4
GO:0046777
protein amino acid autophosphorylation
IGF1R,NLK,MOB1B,MAP3K10,KIT,SMG1,WNT2,TGFBR1,MTOR,
3.35E-4
GO:0043066
negative regulation of apoptosis
HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,
3.57E-4
GO:0060541
respiratory system development
BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,
3.60E-4
GO:0007389
pattern specification process
BMPR2,WNT3A,NOTCH4,PBX2,NOTCH2,EP300,NOTCH1,CDX2,ZEB2,RNF2,HIPK2,LFNG,NRP1,ATM,TGFBR1,NKX3-2,
3.91E-4
GO:0043193
positive regulation of gene-specific transcription
HMGB2,HNRNPAB,PROX1,NOTCH1,TAF2,XRCC6,GATA6,BPTF,SCAP,
3.93E-4
GO:0051276
chromosome organization
HMGB2,KAT2B,HMGB1,EP300,EYA4,SMCHD1,H1F0,TAF5L,H2AFY,HIST1H1E,CBX7,HUWE1,H3F3B,RNF2,HIST1H3D,NPM2,HDAC6,ARID1A,XRCC6,BPTF,TRRAP,HIST2H4B,SIRT1,
3.98E-4
GO:0051347
positive regulation of transferase activity
PTPN11,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,PFKFB2,TGFBR1,LRRN3,IL2,
4.17E-4
GO:0010647
positive regulation of cell communication
HRAS,PTPN11,NOTCH2,PTGS2,TMED7,GRIA2,KRAS,KIT,TMEM189,UBB,CAT,ZEB2,MTOR,HIPK2,HDAC6,TAB2,TGFBR1,IL2,
4.30E-4
GO:0006266
DNA ligation
MGMT,HMGB2,HMGB1,XRCC6,
4.36E-4
GO:0051153
regulation of striated muscle cell differentiation
ZFHX3,BCL2,PROX1,NOTCH1,ITGB1BP3,UBB,
4.37E-4
GO:0006468
protein amino acid phosphorylation
SIK2,PTPN11,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,HIPK2,MOB1B,TGFBR3,NRBP1,TGFBR1,BMPR2,SRPK2,BCL2,EPHA5,NLK,MAP2K1,CHRFAM7A,MAP3K10,KIT,FGFR1,GAB1,GADD45G,ATM,SMG1,LRRN3,
5.35E-4
GO:0009725
response to hormone stimulus
PTEN,BCL2,HMGB2,PTPN11,SIK2,KAT2B,BRCA1,EP300,PTGS2,MAP2K1,KRAS,WNT2,MTOR,IGF1R,GAB1,TGFBR3,FOS,TIMP3,TGFBR1,
5.43E-4
GO:0033554
cellular response to stress
PTPN11,HMGB2,EYA4,HMGB1,PTPLAD1,XIAP,CAT,SCAP,MGMT,HIPK2,HDAC6,BMPR2,BCL2,BRCA1,ATG10,MAP3K10,GAB1,GADD45G,PRDX3,ATM,ZNF12,XRCC6,FOS,SMG1,SIRT1,
5.78E-4
GO:0007167
enzyme linked receptor protein signaling pathway
BMPR2,PTEN,EPHA5,NLK,PTPN11,SIK2,GIGYF1,PRLR,TGFBRAP1,KIT,FGFR1,IGF1R,HIPK2,GAB1,NRP1,TGFBR3,FOS,TGFBR1,
6.65E-4
GO:0045860
positive regulation of protein kinase activity
PTPN11,PRLR,PTPLAD1,MAP2K1,CHRFAM7A,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,TGFBR1,LRRN3,IL2,
6.71E-4
GO:0016310
phosphorylation
PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,MOB1B,ATP6V0E1,TGFBR3,NRBP1,TGFBR1,BMPR2,SRPK2,BCL2,EPHA5,NLK,CHRFAM7A,MAP2K1,MAP3K10,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,
9.22E-4
GO:0044093
positive regulation of molecular function
PTPN11,PRLR,EP300,PTPLAD1,KRAS,TMEM189,CAT,TSHR,HIPK2,NPM2,PFKFB2,TGFBR3,TGFBR1,IL2,BCL2,MAP2K1,CHRFAM7A,MAP3K10,KIT,UBB,ZEB2,GAB1,GADD45G,PRDX3,LRRN3,
9.39E-4
GO:0030163
protein catabolic process
TMEM189,YOD1,USP24,XIAP,MTOR,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,
9.58E-4
GO:0008361
regulation of cell size
BCL2,NOTCH2,EP300,CDKN1B,FGFR1,MTOR,NRP1,ATP6V0E1,TGFBR3,ENO1,CCNG1,TGFBR1,IL2,
1.07E-2
GO:0051147
regulation of muscle cell differentiation
ZFHX3,BCL2,PROX1,NOTCH1,ITGB1BP3,UBB,
1.11E-2
GO:0035239
tube morphogenesis
WNT3A,BCL2,NOTCH4,SPRY2,NRP1,TCF21,NOTCH1,ARHGAP35,BCL2L11,ZEB2,
1.16E-2
GO:0043067
regulation of programmed cell death
HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,KIT,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,
1.17E-2
GO:0080135
regulation of cellular response to stress
HIPK2,GAB1,BRCA1,PTPLAD1,MAP3K10,TMEM189,ZEB2,SIRT1,MTOR,
1.21E-2
GO:0010941
regulation of cell death
HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,KIT,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,
1.24E-2
GO:0051603
proteolysis involved in cellular protein catabolic process
YOD1,USP24,TMEM189,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,
1.30E-2
GO:0044257
cellular protein catabolic process
YOD1,USP24,TMEM189,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,
1.38E-2
GO:0016049
cell growth
BCL2,NOTCH2,TGFBR3,ATP6V0E1,CCNG1,FGFR1,MTOR,
1.48E-2
GO:0042127
regulation of cell proliferation
HRAS,NOTCH4,NOTCH2,NOTCH1,KRAS,CDKN1B,CDX2,WNT2,MTOR,TSHR,IGF1R,HIPK2,TGFBR3,TGFBR1,IL2,BMPR2,PTEN,BCL2,KAT2B,PTGS2,BRCA1,CHRFAM7A,PROX1,KIT,HEY2,FGFR1,NRP1,EIF5A,PRDX3,SIRT1,
1.48E-2
GO:0000904
cell morphogenesis involved in differentiation
WNT3A,NOTCH4,BCL2,PTPN11,NOTCH1,PROX1,UBB,IGF1R,UCHL1,PTPRZ1,OTX2,HNRNPAB,NRP1,TGFBR3,
1.52E-2
GO:0048742
regulation of skeletal muscle fiber development
ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,
1.52E-2
GO:0043632
modification-dependent macromolecule catabolic process
USP28,UBA2,UBR7,FBXO34,ATG10,BRCA1,ASB13,RNF34,TMEM189,YOD1,USP24,XIAP,UBB,FBXO28,FBXO11,HUWE1,KLHL15,RNF2,UCHL1,HERC3,USP10,MGRN1,CYLD,FBXO33,
1.59E-2
GO:0019941
modification-dependent protein catabolic process
USP28,UBA2,UBR7,FBXO34,ATG10,BRCA1,ASB13,RNF34,TMEM189,YOD1,USP24,XIAP,UBB,FBXO28,FBXO11,HUWE1,KLHL15,RNF2,UCHL1,HERC3,USP10,MGRN1,CYLD,FBXO33,
1.59E-2
GO:0035020
regulation of Rac protein signal transduction
HRAS,KRAS,ARF6,MTOR,
1.61E-2
GO:0045596
negative regulation of cell differentiation
NOTCH4,NOTCH2,NOTCH1,KIT,ITGB1BP3,CDX2,TCL1A,ZFHX3,NRP1,TGFBR3,HIST2H4B,TGFBR1,SIRT1,
1.61E-2
GO:0032268
regulation of cellular protein metabolic process
BMPR2,BCL2,ATG10,BRCA1,EP300,PTPLAD1,MAP3K10,UBB,HSP90AB1,NRD1,ZEB2,MTOR,METAP1,EIF4E2,GAB1,PUM1,EIF5A,HDAC6,TIMP3,TGFBR1,IL2,
1.77E-2
GO:0044265
cellular macromolecule catabolic process
TMEM189,YOD1,USP24,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,ZFP36L2,USP28,UBA2,UBR7,FBXO34,ATG10,ASB13,BRCA1,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,ATM,FBXO33,SMG1,
1.88E-2
GO:0048545
response to steroid hormone stimulus
PTEN,BCL2,HMGB2,PTGS2,BRCA1,EP300,MAP2K1,KRAS,FOS,TIMP3,WNT2,TGFBR1,
1.96E-2
GO:0042981
regulation of apoptosis
HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,
2.04E-2
GO:0051270
regulation of cell motion
IGF1R,PTEN,BCL2,GAB1,NRP1,HDAC6,MAP2K1,TGFBR3,KIT,CDKN1B,TGFBR1,LAMA3,
2.05E-2
GO:0045165
cell fate commitment
TEAD4,WNT3A,BCL2,NOTCH4,SPRY2,NOTCH2,PROX1,NOTCH1,TGFBR1,MCL1,
2.18E-2
GO:0009952
anterior/posterior pattern formation
BMPR2,RNF2,WNT3A,HIPK2,LFNG,EP300,ATM,NOTCH1,TGFBR1,ZEB2,
2.29E-2
GO:0009057
macromolecule catabolic process
TMEM189,YOD1,USP24,XIAP,MTOR,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,ZFP36L2,USP28,UBA2,UBR7,FBXO34,ATG10,ASB13,BRCA1,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,ATM,FBXO33,SMG1,
2.68E-2
GO:0048641
regulation of skeletal muscle tissue development
ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,
2.69E-2
GO:0003006
reproductive developmental process
BCL2,HMGB2,PTGS2,KIT,HSD17B3,MTOR,IGF1R,RQCD1,LFNG,NPM2,TCF21,OCA2,BCL2L11,SIRT1,
2.85E-2
GO:0034728
nucleosome organization
H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,ARID1A,HIST2H4B,HIST1H1E,
2.90E-2
GO:0009967
positive regulation of signal transduction
HRAS,PTPN11,NOTCH2,TMED7,KRAS,KIT,TMEM189,CAT,ZEB2,MTOR,HIPK2,HDAC6,TAB2,TGFBR1,IL2,
2.99E-2
GO:0043388
positive regulation of DNA binding
HIPK2,PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,
3.00E-2
GO:0010551
regulation of specific transcription from RNA polymerase II promoter
HMGB2,NOTCH1,TAF2,XRCC6,GATA6,SIRT1,HEY2,SCAP,
3.08E-2
GO:0051101
regulation of DNA binding
HIPK2,PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,
3.34E-2
GO:0030097
hemopoiesis
BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PRDX3,PTPN22,TGFBR3,IL2,
3.36E-2
GO:0016202
regulation of striated muscle tissue development
ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,HEY2,
3.41E-2
GO:0010033
response to organic substance
PTPN11,SIK2,HMGB2,EP300,TAF2,KRAS,WNT2,MTOR,IGF1R,PFKFB2,HDAC6,ATP6V0E1,TGFBR3,TGFBR1,PTEN,BCL2,KAT2B,PTGS2,BRCA1,CHRFAM7A,MAP2K1,HSP90AB1,MCL1,GAB1,PRDX3,FOS,TIMP3,
3.47E-2
GO:0012501
programmed cell death
HRAS,PTEN,E2F1,BAG2,BCL2,BRCA1,EP300,KIT,RNF34,KRAS,GATA6,ARF6,XIAP,CDKN1B,UBB,DDIT4,MCL1,HIPK2,TIAL1,GADD45G,ATM,BCL2L11,SIRT1,DIDO1,
3.50E-2
GO:0048634
regulation of muscle development
ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,HEY2,
3.72E-2
GO:0032535
regulation of cellular component size
BCL2,NOTCH2,EP300,CDKN1B,ARF6,FGFR1,MTOR,NRP1,ATP6V0E1,TGFBR3,ENO1,CCNG1,TGFBR1,IL2,
3.80E-2
GO:0048729
tissue morphogenesis
BMPR2,WNT3A,BCL2,NOTCH2,TCF21,PROX1,NOTCH1,TGFBR3,ARHGAP35,TBX4,ZEB2,
3.87E-2
GO:0051098
regulation of binding
HIPK2,BCL2,PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,
4.16E-2
GO:0016568
chromatin modification
KAT2B,EP300,EYA4,TAF5L,H2AFY,CBX7,HUWE1,RNF2,NPM2,HDAC6,ARID1A,TRRAP,BPTF,SIRT1,
4.19E-2
GO:0016311
dephosphorylation
PTEN,PTPRZ1,BCL2,PTPN11,PHPT1,PTPN22,MTMR12,DUSP5,DUSP6,MTMR3,
4.34E-2
GO:0040007
growth
BCL2,PTPN11,NOTCH2,PTGS2,NOTCH1,TGFBR3,ATP6V0E1,TIMP3,CCNG1,FGFR1,MTOR,
4.36E-2
GO:0001889
liver development
EP300,PROX1,NOTCH1,TGFBR3,GATA6,ARF6,
4.39E-2
GO:0000165
MAPKKK cascade
GAB1,PTPN11,GADD45G,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,TGFBR1,LRRN3,DUSP6,FGFR1,
4.53E-2
GO:0051094
positive regulation of developmental process
BMPR2,BCL2,CHRFAM7A,NOTCH1,PROX1,MAP2K1,KIT,GATA6,CDX2,HEY2,TGIF2,ZFHX3,XRCC6,IL2,
4.73E-2
GO:0051090
regulation of transcription factor activity
PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,
5.11E-2
GO:0051099
positive regulation of binding
HIPK2,PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,
5.14E-2
GO:0010627
regulation of protein kinase cascade
PTEN,TMED7,PTPLAD1,MAP3K10,TMEM189,CAT,ZEB2,MTOR,HIPK2,GAB1,TAB2,TGFBR1,IL2,
5.15E-2
GO:0031334
positive regulation of protein complex assembly
HDAC6,CDKN1B,ARF6,WNT2,MTOR,
5.39E-2
GO:0060491
regulation of cell projection assembly
RALA,KIT,TGFBR1,MTOR,
5.46E-2
GO:0018107
peptidyl-threonine phosphorylation
BCL2,NLK,TGFBR1,MTOR,
5.46E-2
GO:0070647
protein modification by small protein conjugation or removal
HUWE1,RNF2,UCHL1,ATG10,BRCA1,HDAC6,TMEM189,TRRAP,UBB,FBXO11,
5.56E-2
GO:0045662
negative regulation of myoblast differentiation
ZFHX3,NOTCH1,ITGB1BP3,
5.89E-2
GO:0010552
positive regulation of specific transcription from RNA polymerase II promoter
HMGB2,NOTCH1,TAF2,XRCC6,GATA6,SCAP,
6.01E-2
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
BMPR2,IGF1R,PTEN,EPHA5,SIK2,GAB1,GIGYF1,PTPN11,NRP1,PRLR,KIT,FGFR1,
6.37E-2
GO:0031175
neuron projection development
WNT3A,PTEN,BCL2,PTPN11,NOTCH1,MAP2K1,UBB,FGFR1,IGF1R,UCHL1,PTPRZ1,OTX2,NRP1,
6.41E-2
GO:0048732
gland development
IGF1R,WNT3A,BCL2,NOTCH4,PRLR,TCF21,WNT2,BCL2L11,TGFBR1,
6.46E-2
GO:0008219
cell death
HRAS,E2F1,BAG2,EP300,KRAS,GATA6,CDKN1B,XIAP,ARF6,HIPK2,BCL2L11,FUS,PTEN,BCL2,BRCA1,KIT,RNF34,UBB,DDIT4,MCL1,TIAL1,GADD45G,ATM,C8A,SIRT1,DIDO1,
6.48E-2
GO:0000902
cell morphogenesis
WNT3A,NOTCH4,BCL2,PTPN11,NOTCH1,PROX1,MAP2K1,UBB,IGF1R,UCHL1,PTPRZ1,OTX2,HNRNPAB,NRP1,NDE1,TGFBR3,
6.48E-2
GO:0000187
activation of MAPK activity
GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,LRRN3,
6.55E-2
GO:0034621
cellular macromolecular complex subunit organization
XPO6,SRPK2,KPNB1,HMGB2,PRLR,H1F0,H2AFY,RPS14,WNT2,HIST1H1E,H3F3B,HIST1H3D,ARID1A,MAZ,HIST2H4B,TMEM48,
6.64E-2
GO:0016265
death
HRAS,E2F1,BAG2,EP300,KRAS,GATA6,CDKN1B,XIAP,ARF6,HIPK2,BCL2L11,FUS,PTEN,BCL2,BRCA1,KIT,RNF34,UBB,DDIT4,MCL1,TIAL1,GADD45G,ATM,C8A,SIRT1,DIDO1,
7.02E-2
GO:0003002
regionalization
BMPR2,RNF2,WNT3A,HIPK2,PBX2,LFNG,EP300,ATM,NOTCH1,TGFBR1,ZEB2,
7.25E-2
GO:0006334
nucleosome assembly
H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,HIST2H4B,HIST1H1E,
7.35E-2
GO:0051091
positive regulation of transcription factor activity
PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,
7.46E-2
GO:0048103
somatic stem cell division
WNT3A,NOTCH1,KIT,
8.13E-2
GO:0018210
peptidyl-threonine modification
BCL2,NLK,TGFBR1,MTOR,
8.51E-2
GO:0031497
chromatin assembly
H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,HIST2H4B,HIST1H1E,
8.68E-2
GO:0030879
mammary gland development
IGF1R,WNT3A,NOTCH4,PRLR,WNT2,BCL2L11,
9.14E-2
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
TEAD4,E2F1,PBX2,HMGB2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,SCAP,HIPK2,XRCC6,FOS,IL2,
9.18E-2
GO:0060284
regulation of cell development
ZFHX3,TGIF2,BCL2,NRP1,PROX1,NOTCH1,TGFBR3,ITGB1BP3,KIT,XRCC6,UBB,
9.46E-2
GO:0051092
positive regulation of NF-kappaB transcription factor activity
PRDX3,TGFBR3,KRAS,TMEM189,CAT,
9.49E-2