ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-133b

MI0000748	MIPF0000034	GGCCUGCCCGACACUCUUUCCCUGUUGCACUACUAUAGGCCGCUGGGAAGCAGUGCAAUGAUGAAAGGGCAUCGGUCAGGUC	MIMAT0000691 hsa-miR-130b-3p	CAGUGCAAUGAUGAAAGGGCAU	This sequence is the predicted human homologue of mouse miR-130b clonedfrom mouse embryonic stem cells [1,2]. Its expression was later verifiedin human BC-1 cells .
MI0000748	MIPF0000034	GGCCUGCCCGACACUCUUUCCCUGUUGCACUACUAUAGGCCGCUGGGAAGCAGUGCAAUGAUGAAAGGGCAUCGGUCAGGUC	MIMAT0004680 hsa-miR-130b-5p	ACUCUUUCCCUGUUGCACUAC	This sequence is the predicted human homologue of mouse miR-130b clonedfrom mouse embryonic stem cells [1,2]. Its expression was later verifiedin human BC-1 cells .
MI0000453	MIPF0000028	AGAUAAAUUCACUCUAGUGCUUUAUGGCUUUUUAUUCCUAUGUGAUAGUAAUAAAGUCUCAUGUAGGGAUGGAAGCCAUGAAAUACAUUGUGAAAAAUCA	MIMAT0000428 hsa-miR-135a-5p	UAUGGCUUUUUAUUCCUAUGUGA
MI0000452	MIPF0000028	AGGCCUCGCUGUUCUCUAUGGCUUUUUAUUCCUAUGUGAUUCUACUGCUCACUCAUAUAGGGAUUGGAGCCGUGGCGCACGGCGGGGACA	MIMAT0004595 hsa-miR-135a-3p	UAUAGGGAUUGGAGCCGUGGCG	miR-135a was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells .
MI0000453	MIPF0000028	AGAUAAAUUCACUCUAGUGCUUUAUGGCUUUUUAUUCCUAUGUGAUAGUAAUAAAGUCUCAUGUAGGGAUGGAAGCCAUGAAAUACAUUGUGAAAAAUCA	MIMAT0000428 hsa-miR-135a-5p	UAUGGCUUUUUAUUCCUAUGUGA
MI0000452	MIPF0000028	AGGCCUCGCUGUUCUCUAUGGCUUUUUAUUCCUAUGUGAUUCUACUGCUCACUCAUAUAGGGAUUGGAGCCGUGGCGCACGGCGGGGACA	MIMAT0004595 hsa-miR-135a-3p	UAUAGGGAUUGGAGCCGUGGCG	miR-135a was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells .
MI0000453	MIPF0000028	AGAUAAAUUCACUCUAGUGCUUUAUGGCUUUUUAUUCCUAUGUGAUAGUAAUAAAGUCUCAUGUAGGGAUGGAAGCCAUGAAAUACAUUGUGAAAAAUCA	MIMAT0000428 hsa-miR-135a-5p	UAUGGCUUUUUAUUCCUAUGUGA
MI0000452	MIPF0000028	AGGCCUCGCUGUUCUCUAUGGCUUUUUAUUCCUAUGUGAUUCUACUGCUCACUCAUAUAGGGAUUGGAGCCGUGGCGCACGGCGGGGACA	MIMAT0004595 hsa-miR-135a-3p	UAUAGGGAUUGGAGCCGUGGCG	miR-135a was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells .
MI0000822	MIPF0000029	CCUCAGAAGAAAGAUGCCCCCUGCUCUGGCUGGUCAAACGGAACCAAGUCCGUCUUCCUGAGAGGUUUGGUCCCCUUCAACCAGCUACAGCAGGGCUGGCAAUGCCCAGUCCUUGGAGA	MIMAT0000770 hsa-miR-133b	UUUGGUCCCCUUCAACCAGCUA
MI0000453	MIPF0000028	AGAUAAAUUCACUCUAGUGCUUUAUGGCUUUUUAUUCCUAUGUGAUAGUAAUAAAGUCUCAUGUAGGGAUGGAAGCCAUGAAAUACAUUGUGAAAAAUCA	MIMAT0000428 hsa-miR-135a-5p	UAUGGCUUUUUAUUCCUAUGUGA
MI0000452	MIPF0000028	AGGCCUCGCUGUUCUCUAUGGCUUUUUAUUCCUAUGUGAUUCUACUGCUCACUCAUAUAGGGAUUGGAGCCGUGGCGCACGGCGGGGACA	MIMAT0004595 hsa-miR-135a-3p	UAUAGGGAUUGGAGCCGUGGCG	miR-135a was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

PITX3,CPNE3,MYC,FSCN1,RB1CC1,PTPRK,HCN4,SIRT1,FAIM,TGFBR2,BCL2L2,EGFR,PPP2R1A,MET,ERG
more » PITX3,CPNE3,MYC,FSCN1,RB1CC1,PTPRK,HCN4,SIRT1,FAIM,TGFBR2,BCL2L2,EGFR,PPP2R1A,MET,ERG,KCNH2,CDK13,PPP2R1B,SIAH1,TGFB1,MCL1,PRDM16,FGFR1,HOXA10,IGF1R,HCN2,PKM2,NR3C2,PTBP2

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05210	Colorectal cancer	IGF1R,TGFB1,EGFR,TGFBR2,MET,MYC,	7.89E-7
hsa04520	Adherens junction	IGF1R,EGFR,TGFBR2,MET,FGFR1,	2.19E-5
hsa04350	TGF-beta signaling pathway	TGFB1,PPP2R1A,PPP2R1B,TGFBR2,MYC,	3.56E-5
hsa05200	Pathways in cancer	IGF1R,TGFB1,EGFR,TGFBR2,MET,MYC,FGFR1,	4.56E-5
hsa05218	Melanoma	IGF1R,EGFR,MET,FGFR1,	5.24E-4

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0042981	regulation of apoptosis	RB1CC1,IGF1R,TGFB1,FAIM,BCL2L2,EGFR,PPP2R1A,SIRT1,MYC,JAK2,MCL1,	2.55E-6
GO:0043067	regulation of programmed cell death	RB1CC1,IGF1R,TGFB1,FAIM,BCL2L2,EGFR,PPP2R1A,SIRT1,MYC,JAK2,MCL1,	2.79E-6
GO:0010941	regulation of cell death	RB1CC1,IGF1R,TGFB1,FAIM,BCL2L2,EGFR,PPP2R1A,SIRT1,MYC,JAK2,MCL1,	2.89E-6
GO:0007167	enzyme linked receptor protein signaling pathway	IGF1R,PTPRK,TGFB1,EGFR,TGFBR2,MET,FGFR1,JAK2,	4.65E-6
GO:0006793	phosphorus metabolic process	IGF1R,CDK13,PTPRK,TGFB1,EGFR,PPP2R1A,TGFBR2,MET,ERG,FGFR1,JAK2,	1.40E-5

GO:0006796	phosphate metabolic process	IGF1R,CDK13,PTPRK,TGFB1,EGFR,PPP2R1A,TGFBR2,MET,ERG,FGFR1,JAK2,	1.40E-5
GO:0008284	positive regulation of cell proliferation	IGF1R,CDK13,TGFB1,EGFR,TGFBR2,MYC,FGFR1,JAK2,	1.62E-5
GO:0042127	regulation of cell proliferation	IGF1R,CDK13,PTPRK,TGFB1,EGFR,TGFBR2,SIRT1,MYC,FGFR1,JAK2,	1.84E-5
GO:0000165	MAPKKK cascade	RB1CC1,EGFR,PPP2R1A,MET,FGFR1,JAK2,	3.36E-5
GO:0006468	protein amino acid phosphorylation	IGF1R,CDK13,TGFB1,EGFR,TGFBR2,MET,ERG,FGFR1,JAK2,	4.31E-5
GO:0043066	negative regulation of apoptosis	RB1CC1,IGF1R,FAIM,BCL2L2,EGFR,MYC,MCL1,	7.11E-5
GO:0008219	cell death	TGFB1,FAIM,BCL2L2,PKM2,SIAH1,SIRT1,MYC,JAK2,MCL1,	7.36E-5
GO:0043069	negative regulation of programmed cell death	RB1CC1,IGF1R,FAIM,BCL2L2,EGFR,MYC,MCL1,	7.69E-5
GO:0016265	death	TGFB1,FAIM,BCL2L2,PKM2,SIAH1,SIRT1,MYC,JAK2,MCL1,	7.72E-5
GO:0060548	negative regulation of cell death	RB1CC1,IGF1R,FAIM,BCL2L2,EGFR,MYC,MCL1,	7.81E-5
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IGF1R,TGFB1,EGFR,MET,FGFR1,JAK2,	8.57E-5
GO:0007243	protein kinase cascade	RB1CC1,IGF1R,EGFR,PPP2R1A,MET,FGFR1,JAK2,	9.09E-5
GO:0033158	regulation of protein import into nucleus, translocation	TGFB1,SIRT1,JAK2,	1.47E-4
GO:0016310	phosphorylation	IGF1R,CDK13,TGFB1,EGFR,TGFBR2,MET,ERG,FGFR1,JAK2,	1.55E-4
GO:0012501	programmed cell death	FAIM,BCL2L2,PKM2,SIAH1,SIRT1,MYC,JAK2,MCL1,	1.91E-4
GO:0008283	cell proliferation	TGFB1,BCL2L2,EGFR,FSCN1,MET,ERG,MYC,	2.23E-4
GO:0042325	regulation of phosphorylation	RB1CC1,TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	3.19E-4
GO:0019725	cellular homeostasis	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,MCL1,	3.19E-4
GO:0030334	regulation of cell migration	IGF1R,PTPRK,TGFB1,EGFR,JAK2,	3.80E-4
GO:0051174	regulation of phosphorus metabolic process	RB1CC1,TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	3.95E-4
GO:0019220	regulation of phosphate metabolic process	RB1CC1,TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	3.95E-4
GO:0032504	multicellular organism reproduction	TGFB1,BCL2L2,HOXA10,EGFR,SIAH1,MET,SIRT1,	4.04E-4
GO:0048609	reproductive process in a multicellular organism	TGFB1,BCL2L2,HOXA10,EGFR,SIAH1,MET,SIRT1,	4.04E-4
GO:0001932	regulation of protein amino acid phosphorylation	RB1CC1,TGFB1,EGFR,PPP2R1A,JAK2,	4.16E-4
GO:0001501	skeletal system development	TGFB1,HOXA10,EGFR,TGFBR2,MYC,FGFR1,	4.44E-4
GO:0010033	response to organic substance	IGF1R,TGFB1,EGFR,PPP2R1A,TGFBR2,MYC,JAK2,MCL1,	5.24E-4
GO:0048666	neuron development	IGF1R,EGFR,PITX3,SIAH1,FGFR1,JAK2,	5.86E-4
GO:0040012	regulation of locomotion	IGF1R,PTPRK,TGFB1,EGFR,JAK2,	6.16E-4
GO:0033993	response to lipid	TGFB1,EGFR,TGFBR2,	6.19E-4
GO:0051270	regulation of cell motion	IGF1R,PTPRK,TGFB1,EGFR,JAK2,	6.28E-4
GO:0045859	regulation of protein kinase activity	TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	6.35E-4
GO:0046777	protein amino acid autophosphorylation	IGF1R,EGFR,MET,JAK2,	7.00E-4
GO:0043549	regulation of kinase activity	TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	7.41E-4
GO:0030335	positive regulation of cell migration	IGF1R,TGFB1,EGFR,JAK2,	8.00E-4
GO:0051338	regulation of transferase activity	TGFB1,EGFR,PPP2R1A,TGFBR2,MET,JAK2,	8.92E-4
GO:0006873	cellular ion homeostasis	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,	9.14E-4
GO:0055082	cellular chemical homeostasis	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,	9.82E-4
GO:0042327	positive regulation of phosphorylation	RB1CC1,TGFB1,EGFR,JAK2,	1.02E-2
GO:0051272	positive regulation of cell motion	IGF1R,TGFB1,EGFR,JAK2,	1.05E-2
GO:0040017	positive regulation of locomotion	IGF1R,TGFB1,EGFR,JAK2,	1.05E-2
GO:0045860	positive regulation of protein kinase activity	TGFB1,EGFR,TGFBR2,MET,JAK2,	1.07E-2
GO:0010562	positive regulation of phosphorus metabolic process	RB1CC1,TGFB1,EGFR,JAK2,	1.12E-2
GO:0045937	positive regulation of phosphate metabolic process	RB1CC1,TGFB1,EGFR,JAK2,	1.12E-2
GO:0033674	positive regulation of kinase activity	TGFB1,EGFR,TGFBR2,MET,JAK2,	1.22E-2
GO:0006915	apoptosis	FAIM,BCL2L2,SIAH1,SIRT1,MYC,JAK2,MCL1,	1.23E-2
GO:0050801	ion homeostasis	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,	1.36E-2
GO:0051347	positive regulation of transferase activity	TGFB1,EGFR,TGFBR2,MET,JAK2,	1.41E-2
GO:0051052	regulation of DNA metabolic process	IGF1R,TGFB1,PPP2R1A,MYC,	1.63E-2
GO:0031175	neuron projection development	IGF1R,EGFR,SIAH1,FGFR1,JAK2,	1.79E-2
GO:0030182	neuron differentiation	IGF1R,EGFR,PITX3,SIAH1,FGFR1,JAK2,	1.84E-2
GO:0048732	gland development	IGF1R,TGFB1,EGFR,MET,	2.65E-2
GO:0043405	regulation of MAP kinase activity	TGFB1,EGFR,PPP2R1A,MET,	3.00E-2
GO:0031399	regulation of protein modification process	RB1CC1,TGFB1,EGFR,PPP2R1A,JAK2,	3.00E-2
GO:0045449	regulation of transcription	PTPRK,PRDM16,NR3C2,HOXA10,ERG,JAK2,RB1CC1,TGFB1,KCNH2,PPP2R1A,PITX3,MYC,SIRT1,	3.50E-2
GO:0048878	chemical homeostasis	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,	3.63E-2
GO:0042306	regulation of protein import into nucleus	TGFB1,SIRT1,JAK2,	3.70E-2
GO:0007346	regulation of mitotic cell cycle	CDK13,TGFB1,EGFR,MYC,	3.70E-2
GO:0042592	homeostatic process	TGFB1,KCNH2,NR3C2,HCN2,MYC,JAK2,MCL1,	3.77E-2
GO:0043085	positive regulation of catalytic activity	TGFB1,EGFR,TGFBR2,MET,MYC,JAK2,	3.88E-2
GO:0051726	regulation of cell cycle	CDK13,PTPRK,TGFB1,EGFR,MYC,	4.53E-2
GO:0033157	regulation of intracellular protein transport	TGFB1,SIRT1,JAK2,	5.33E-2
GO:0000902	cell morphogenesis	IGF1R,TGFB1,EGFR,SIAH1,JAK2,	5.85E-2
GO:0046822	regulation of nucleocytoplasmic transport	TGFB1,SIRT1,JAK2,	6.35E-2
GO:0044093	positive regulation of molecular function	TGFB1,EGFR,TGFBR2,MET,MYC,JAK2,	6.43E-2
GO:0030030	cell projection organization	IGF1R,EGFR,SIAH1,FGFR1,JAK2,	6.58E-2
GO:0009628	response to abiotic stimulus	PTPRK,TGFB1,EGFR,TGFBR2,MYC,	6.58E-2
GO:0007179	transforming growth factor beta receptor signaling pathway	PTPRK,TGFB1,TGFBR2,	6.78E-2
GO:0006275	regulation of DNA replication	IGF1R,TGFB1,PPP2R1A,	7.23E-2
GO:0030879	mammary gland development	IGF1R,TGFB1,MET,	7.46E-2
GO:0009314	response to radiation	PTPRK,TGFB1,EGFR,MYC,	7.94E-2
GO:0070723	response to cholesterol	TGFB1,TGFBR2,	8.25E-2
GO:0007276	gamete generation	TGFB1,BCL2L2,HOXA10,SIAH1,SIRT1,	8.41E-2
GO:0032989	cellular component morphogenesis	IGF1R,TGFB1,EGFR,SIAH1,JAK2,	8.56E-2
GO:0008361	regulation of cell size	RB1CC1,TGFB1,PPP2R1A,FGFR1,	8.61E-2
GO:0006916	anti-apoptosis	IGF1R,BCL2L2,MYC,MCL1,	8.61E-2
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	EGFR,PPP2R1A,JAK2,	8.64E-2
GO:0032386	regulation of intracellular transport	TGFB1,SIRT1,JAK2,	9.39E-2
GO:0048812	neuron projection morphogenesis	IGF1R,EGFR,SIAH1,JAK2,	9.43E-2
GO:0051173	positive regulation of nitrogen compound metabolic process	IGF1R,TGFB1,PRDM16,EGFR,MYC,JAK2,	9.51E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value