ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

let-7g

MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0000414 hsa-let-7g-5p	UGAGGUAGUAGUUUGUACAGUU	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0004584 hsa-let-7g-3p	CUGUACAGGCCACUGCCUUGC	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0000414 hsa-let-7g-5p	UGAGGUAGUAGUUUGUACAGUU	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0004584 hsa-let-7g-3p	CUGUACAGGCCACUGCCUUGC	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0000414 hsa-let-7g-5p	UGAGGUAGUAGUUUGUACAGUU	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0000414 hsa-let-7g-5p	UGAGGUAGUAGUUUGUACAGUU	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000433	MIPF0000002	AGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCA	MIMAT0000414 hsa-let-7g-5p	UGAGGUAGUAGUUUGUACAGUU	let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

IL13,KRASP1,HMGA2,BMI1,OLR1,MYC,CDKN2A,AKAP11,SOCS1,HIST1H1E,OPRM1,CCND1,MAP3K1,SART3,IGF2BP1
more » IL13,KRASP1,HMGA2,BMI1,OLR1,MYC,CDKN2A,AKAP11,SOCS1,HIST1H1E,OPRM1,CCND1,MAP3K1,SART3,IGF2BP1,FAS,IL6,DICER1,RRM2,FN1,EIF2C1,BACH1,COL1A2,SFT2D1,RPL12,DCAF8,BCL2L1,GAB2,TBC1D9,LIN28A,CDC34,BRD1,HMGB1,RAB21,KRAS,RANBP2,TRIM71,MAGED1,EEF1A1,CASP3

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05220	Chronic myeloid leukemia	CCND1,BCL2L1,GAB2,CDKN2A,KRAS,MYC,	1.03E-5
hsa05200	Pathways in cancer	CCND1,FAS,BCL2L1,CDKN2A,FN1,KRAS,IL6,CASP3,MYC,	2.66E-5
hsa04115	p53 signaling pathway	CCND1,FAS,CDKN2A,RRM2,CASP3,	1.47E-4
hsa04630	Jak-STAT signaling pathway	CCND1,IL13,BCL2L1,SOCS1,IL6,MYC,	3.38E-4
hsa05219	Bladder cancer	CCND1,CDKN2A,KRAS,MYC,	6.28E-4

hsa05212	Pancreatic cancer	CCND1,BCL2L1,CDKN2A,KRAS,	3.01E-2
hsa05222	Small cell lung cancer	CCND1,BCL2L1,FN1,MYC,	4.66E-2
hsa05210	Colorectal cancer	CCND1,KRAS,CASP3,MYC,	4.66E-2
hsa05216	Thyroid cancer	CCND1,KRAS,MYC,	6.16E-2
hsa04120	Ubiquitin mediated proteolysis	CDC34,MAP3K1,SOCS1,UBE3C,	1.78E-1
hsa05213	Endometrial cancer	CCND1,KRAS,MYC,	1.90E-1
hsa05223	Non-small cell lung cancer	CCND1,CDKN2A,KRAS,	2.04E-1
hsa04010	MAPK signaling pathway	FAS,MAP3K1,KRAS,CASP3,MYC,	2.19E-1
hsa05221	Acute myeloid leukemia	CCND1,KRAS,MYC,	2.33E-1
hsa05214	Glioma	CCND1,CDKN2A,KRAS,	2.72E-1
hsa05218	Melanoma	CCND1,CDKN2A,KRAS,	3.40E-1
hsa04664	Fc epsilon RI signaling pathway	IL13,GAB2,KRAS,	4.04E-1
hsa04210	Apoptosis	FAS,BCL2L1,CASP3,	4.92E-1
hsa04722	Neurotrophin signaling pathway	MAGED1,MAP3K1,KRAS,	9.16E-1
hsa04110	Cell cycle	CCND1,CDKN2A,MYC,	9.29E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0008637	apoptotic mitochondrial changes	MAP3K1,BCL2L1,CDKN2A,CASP3,MYC,	1.41E-6
GO:0050864	regulation of B cell activation	FAS,IL13,CDKN2A,IL6,CASP3,	1.07E-5
GO:0042127	regulation of cell proliferation	CCND1,MAGED1,IL13,OPRM1,BCL2L1,BMI1,CDKN2A,KRAS,IL6,CASP3,MYC,	3.46E-5
GO:0008219	cell death	OLR1,MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,KRAS,IL6,CASP3,MYC,	1.04E-4
GO:0010033	response to organic substance	CCND1,FAS,BCL2L1,DICER1,KRAS,SOCS1,IL6,LIN28A,CASP3,MYC,	1.06E-4

GO:0016265	death	OLR1,MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,KRAS,IL6,CASP3,MYC,	1.10E-4
GO:0044265	cellular macromolecule catabolic process	CDC34,MAP3K1,EIF2C1,CDKN2A,SOCS1,UBE3C,LIN28A,CASP3,MYC,RANBP2,	1.11E-4
GO:0010605	negative regulation of macromolecule metabolic process	BCL2L1,HMGB1,DICER1,EIF2C1,IGF2BP1,CDKN2A,SOCS1,IL6,LIN28A,MYC,	1.22E-4
GO:0006915	apoptosis	MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,KRAS,IL6,CASP3,MYC,	1.80E-4
GO:0009057	macromolecule catabolic process	CDC34,MAP3K1,EIF2C1,CDKN2A,SOCS1,UBE3C,LIN28A,CASP3,MYC,RANBP2,	1.95E-4
GO:0012501	programmed cell death	MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,KRAS,IL6,CASP3,MYC,	1.99E-4
GO:0042981	regulation of apoptosis	MAGED1,FAS,MAP3K1,BCL2L1,HMGB1,CDKN2A,KRAS,IL6,CASP3,MYC,	2.43E-4
GO:0010608	posttranscriptional regulation of gene expression	DICER1,EIF2C1,IGF2BP1,CDKN2A,IL6,LIN28A,	2.55E-4
GO:0043067	regulation of programmed cell death	MAGED1,FAS,MAP3K1,BCL2L1,HMGB1,CDKN2A,KRAS,IL6,CASP3,MYC,	2.62E-4
GO:0010941	regulation of cell death	MAGED1,FAS,MAP3K1,BCL2L1,HMGB1,CDKN2A,KRAS,IL6,CASP3,MYC,	2.69E-4
GO:0043066	negative regulation of apoptosis	FAS,BCL2L1,HMGB1,KRAS,IL6,CASP3,MYC,	3.60E-4
GO:0043069	negative regulation of programmed cell death	FAS,BCL2L1,HMGB1,KRAS,IL6,CASP3,MYC,	3.88E-4
GO:0060548	negative regulation of cell death	FAS,BCL2L1,HMGB1,KRAS,IL6,CASP3,MYC,	3.94E-4
GO:0007005	mitochondrion organization	MAP3K1,BCL2L1,CDKN2A,CASP3,MYC,	5.27E-4
GO:0051249	regulation of lymphocyte activation	FAS,IL13,CDKN2A,IL6,CASP3,	6.86E-4
GO:0008284	positive regulation of cell proliferation	CCND1,IL13,BCL2L1,BMI1,KRAS,IL6,MYC,	8.23E-4
GO:0035195	gene silencing by miRNA	DICER1,EIF2C1,LIN28A,	9.64E-4
GO:0043065	positive regulation of apoptosis	MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,CASP3,MYC,	1.00E-2
GO:0043068	positive regulation of programmed cell death	MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,CASP3,MYC,	1.03E-2
GO:0002694	regulation of leukocyte activation	FAS,IL13,CDKN2A,IL6,CASP3,	1.05E-2
GO:0010942	positive regulation of cell death	MAGED1,FAS,MAP3K1,BCL2L1,CDKN2A,CASP3,MYC,	1.06E-2
GO:0050869	negative regulation of B cell activation	FAS,CDKN2A,CASP3,	1.08E-2
GO:0006309	DNA fragmentation involved in apoptosis	CDKN2A,CASP3,MYC,	1.20E-2
GO:0051384	response to glucocorticoid stimulus	CCND1,FAS,KRAS,IL6,	1.24E-2
GO:0050865	regulation of cell activation	FAS,IL13,CDKN2A,IL6,CASP3,	1.28E-2
GO:0001836	release of cytochrome c from mitochondria	BCL2L1,CASP3,MYC,	1.47E-2
GO:0016441	posttranscriptional gene silencing	DICER1,EIF2C1,LIN28A,	1.47E-2
GO:0035194	posttranscriptional gene silencing by RNA	DICER1,EIF2C1,LIN28A,	1.47E-2
GO:0050670	regulation of lymphocyte proliferation	IL13,CDKN2A,IL6,CASP3,	1.48E-2
GO:0042325	regulation of phosphorylation	CCND1,MAP3K1,CDKN2A,KRAS,SOCS1,IL6,CASP3,	1.51E-2
GO:0032944	regulation of mononuclear cell proliferation	IL13,CDKN2A,IL6,CASP3,	1.54E-2
GO:0070663	regulation of leukocyte proliferation	IL13,CDKN2A,IL6,CASP3,	1.54E-2
GO:0031960	response to corticosteroid stimulus	CCND1,FAS,KRAS,IL6,	1.59E-2
GO:0032268	regulation of cellular protein metabolic process	CCND1,MAP3K1,EIF2C1,IGF2BP1,CDKN2A,SOCS1,IL6,	1.65E-2
GO:0006921	cell structure disassembly during apoptosis	CDKN2A,CASP3,MYC,	1.77E-2
GO:0048545	response to steroid hormone stimulus	CCND1,FAS,KRAS,SOCS1,IL6,	1.80E-2
GO:0051174	regulation of phosphorus metabolic process	CCND1,MAP3K1,CDKN2A,KRAS,SOCS1,IL6,CASP3,	1.85E-2
GO:0019220	regulation of phosphate metabolic process	CCND1,MAP3K1,CDKN2A,KRAS,SOCS1,IL6,CASP3,	1.85E-2
GO:0009314	response to radiation	CCND1,BCL2L1,KRAS,CASP3,MYC,	2.09E-2
GO:0000737	DNA catabolic process, endonucleolytic	CDKN2A,CASP3,MYC,	2.26E-2
GO:0030262	apoptotic nuclear changes	CDKN2A,CASP3,MYC,	2.26E-2
GO:0030888	regulation of B cell proliferation	IL13,CDKN2A,CASP3,	2.63E-2
GO:0009725	response to hormone stimulus	CCND1,FAS,BCL2L1,KRAS,SOCS1,IL6,	3.05E-2
GO:0009628	response to abiotic stimulus	CCND1,MAP3K1,BCL2L1,KRAS,CASP3,MYC,	3.08E-2
GO:0031047	gene silencing by RNA	DICER1,EIF2C1,LIN28A,	3.64E-2
GO:0001776	leukocyte homeostasis	FAS,IL6,CASP3,	4.32E-2
GO:0009719	response to endogenous stimulus	CCND1,FAS,BCL2L1,KRAS,SOCS1,IL6,	4.64E-2
GO:0044093	positive regulation of molecular function	CCND1,OPRM1,MAP3K1,CDKN2A,KRAS,IL6,MYC,	4.75E-2
GO:0031399	regulation of protein modification process	CCND1,MAP3K1,CDKN2A,SOCS1,IL6,	8.30E-2
GO:0006997	nucleus organization	CDKN2A,CASP3,MYC,	8.85E-2
GO:0022411	cellular component disassembly	CDKN2A,CASP3,MYC,	9.18E-2
GO:0051250	negative regulation of lymphocyte activation	FAS,CDKN2A,CASP3,	9.52E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CDKN2A,CASP3,	9.52E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value