Detail: | |
ncRNA Symmbol: | miR-139-5p |
---|---|
ncRNA Category: | miRNA |
Interaction Gene Symbol: | PARP1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | up |
Species: | Homo sapiens |
Tissue: | colorectal cell |
PMID: | 24885920 |
Detail Description: | MiR-139-5p was significantly down-regulated in primary tumor tissues (P?0.0001). Ectopic expression of miR-139-5p in colon cancer cell lines significantly suppressed cell growth as evidenced by cell viability assay (P?0.001) and colony formation assay (P?0.01) and in xenograft tumor growth in nude mice (P?0.01). miR-139-5p induced apoptosis (P?0.01), concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8, caspase-3, caspase-7 and PARP. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.