Detail: | |
ncRNA Symmbol: | miR-138 |
---|---|
ncRNA Category: | miRNA |
Interaction Gene Symbol: | LYPLA1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | chronic lymphocytic leukemia (CLL) cell |
PMID: | 25670628 |
Detail Description: | Previously, we could show that miR-138 and -424 are down-regulated in CLL cells. Here, we identified two new target genes, namely acyl protein thioesterase (APT) 1 and 2, which are under control of both miRs and thereby significantly over-expressed in CLL cells.Specific inhibition of APTs by siRNAs, treatment with miRs-138/-424 and pharmacological approaches restore CD95-mediated apoptosis in CLL cells and other cancer cells, pointing to an important regulatory role of APTs in CD95 apoptosis. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.