Detail: | |
ncRNA Symmbol: | p53-mRNA |
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ncRNA Category: | lncRNA |
Interaction Gene Symbol: | PITX1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | |
Species: | Homo sapiens |
Tissue: | mammary carcinoma cells |
PMID: | 17762884 |
Detail Description: | Increased p53 mrna expression was due to activation of the p53 promoter by hPitx1. Forced expression of hpitx1 resulted in cell-cycle arrest and p53-dependent apoptosis in p53-replete MCF-7 cells. Furthermore, hPitx1 stimulated the transcription of p53 target genes involved in cell-cycle arrest and apoptosis (p21 and ptgf-beta), again in a p53-dependent manner.Depletion of p53 by sirna dramatically attenuated hpitx1-induced apoptosis in MCF-7 cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.