Detail: | |
ncRNA Symmbol: | ANRIL |
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ncRNA Category: | lncRNA |
Interaction Gene Symbol: | E2F1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | |
Species: | Homo sapiens |
Tissue: | |
PMID: | 23416462 |
Detail Description: | Consistent with the results from the apoptosis assays, depletion of ANRIL resulted in an increase in the sensitivity of HCT116 p53+/+ cells to the treatment with neocarzinostatin (NCS), confirming that lowered levels of ANRIL in cells led to elevated apoptosis in the DNA damage response(DDR).In the present study, we demonstrate that one specific lncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage, |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.