Detail: | |
ncRNA Symmbol: | miR-20a |
---|---|
ncRNA Category: | miRNA |
Interaction Gene Symbol: | ATG12 |
Death Pathway: | autophagy |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | osteoclast |
PMID: | 25485521 |
Detail Description: | Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.