The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:miR-133
ncRNA Category:miRNA
Interaction Gene Symbol: Adrb1
Death Pathway:apoptosis
Expression Direction of ncRNA:up
Species:Mus musculus
Tissue:
PMID: 24807785
Detail Description:

Consistently, cAMP accumulation and activation of downstream targets were repressed by miR-133 overexpression in both neonatal and adult cardiomyocytes following selective ¦Â1AR stimulation. Furthermore, gain-of-function and loss-of-function studies of miR-133 revealed its role in counteracting the deleterious apoptotic effects caused by chronic ¦Â1AR stimulation. This was confirmed in vivo using a novel cardiac-specific TetON-miR-133 inducible transgenic mouse model. 

Select the ncRNA symbol and transcript of gene
Mature of miR-133    Transcript of Adrb1    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.