| Detail: | |
| ncRNA Symmbol: | Smad7 |
|---|---|
| ncRNA Category: | lncRNA |
| Interaction Gene Symbol: | Tgfb1 |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | up |
| Species: | Mus musculus |
| Tissue: | breast cancer JygMC(A) cell |
| PMID: | 24863656 |
| Detail Description: | LncRNA-Smad7 was located adjacent to the mouse Smad7 gene, and its expression was induced by TGF-¦Â in all of the mouse mammary gland epithelial cell lines and breast cancer cell lines that we evaluated. Suppression of lncRNA-Smad7 expression cancelled the anti-apoptotic function of TGF-¦Â. In contrast, forced expression of lncRNA-Smad7 rescued apoptosis induced by a TGF-¦Â type I receptor kinase inhibitor in the mouse breast cancer cell line JygMC(A). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.