Detail: | |
ncRNA Symmbol: | miR-342 |
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ncRNA Category: | miRNA |
Interaction Gene Symbol: | ESR1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | up |
Species: | Homo sapiens |
Tissue: | breast cancer cell |
PMID: | 23408138 |
Detail Description: | The expression levels of miR-342 and ER¦Á mRNA were analyzed in human breast cancer samples and cell lines by quantitative reverse transcription (RT)-PCR analysis. Statistically significant associations were observed between miR-342 and ER, HER2 and vascular endothelial growth factor (VEGF) status in the human breast cancer samples and the levels of miR-342 gradually increased as ER¦Á mRNA expression increased. Moreover, ectopic overexpression of miR-342 upregulated the expression levels of the ER¦Á mRNA and significantly sensitized the MCF-7 cells to tamoxifen-induced apoptosis and inhibition of cellular proliferation. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.