In MNDR v2.0, the ncRNA-disease associations are collected from different types of resources under one common framework, including experimental and prediction evidence. In principle, we assume that:
1. Experimental evidence should contribute more important to the confidence score than prediction evidence;
2. Strong experimental evidence should provide more reliable evidence than weak experimental evidence;
3. ncRNA-disease associations supported by more evidence should be given significantly higher confidence scores than those supported by fewer evidence.
Similar to RAID v2.0 database, according to the evidence types and number of evidence resources, we calculate the confidence score (S) for each ncRNA-disease association as follows:
where i is the evidence type(s: strong experimental evidence, w: weak experimental evidence, p: computational prediction method), x is the number of evidence resources, we set weight factor Ws, Ww and Wp to 1, 0.65, and 0.15, respectively(if x=0, we set weight factor Wi to 0).